Parenting capacities and health outcomes in youths and adolescents (R21).This program announcement solicits research aimed at increasing parenting capacities while simultaneously focusing on the reduction, elimination, or prevention of one or more high-risk health behaviors or poor health habits in youth and adolescent children. Investigators responding to this announcement are required to target two or more ineffective parenting practices or behaviors (e.g., lack of appropriate parental monitoring, supervision, and communication, high family conflict and disorganization disorganization /dis·or·gan·iza·tion/ (-or?gan-i-za´shun) the process of destruction of any organic tissue; any profound change in the tissues of an organ or structure which causes the loss of most or all of its proper characters. , parental stress and depression, lack of parent-child bonding, and negative discipline methods) and two or more youth/adolescent high-risk behaviors (e.g., unhealthy dietary behaviors, inadequate physical activity, tobacco use, alcohol and other drug use, sexual behaviors, and unintentional (accidents) and intentional behaviors (firearm-related injuries). These behaviors are frequently established during childhood and adolescent years and continue on to the adult years. These behaviors are potentially amenable to a variety of health promotion and prevention efforts. As part of the national efforts to eliminate health disparities
Health disparities (also called health inequalities in some countries) refer to gaps in the quality of health and health care across racial, ethnic, and socioeconomic groups. , proposals specifically targeting racial/ethnic minority populations are strongly encouraged. Strategic Plans on Reducing Health Disparities are located at http://www.nih.gov/ninr, http:// www.nhlbi.nih.gov/resources/docs/plan/reduct.htm, http://www.niaaa.nih.gov, http://www.nichd.nih.gov, and http://www.nida.nih.gov.
Research targeting other diverse groups of parents and their youths/adolescents is also encouraged (e.g., sexual orientation sexual orientation
The direction of one's sexual interest toward members of the same, opposite, or both sexes, especially a direction seen to be dictated by physiologic rather than sociologic forces. , religious background, single-parent families). For purposes of this announcement, children ranging in age from 10-18 years can be targeted.
It is well documented that the probability of children and adolescents acquiring nonoptimal health behaviors and developmental problems increases substantially in the presence of ineffective parenting practices. Specifically, there is empirical support for the notion that many early precursors of serious middle childhood and adolescent problems can be significantly reduced or thwarted through effective early interventions aimed at improving parenting practices and family dynamics. While it would be gross over simplification to equate child and adolescent developmental, behavioral, and health outcomes to products of child-rearing practices, parental and caregiver behaviors and practices do have a large impact and exert perhaps the most significant and pervasive influence over the health risk behaviors and health habits of their adolescent children.
Undoubtedly, genes, peers, the mass media, school, neighborhood, and other societal and cultural influences do play a role in shaping child and adolescent developmental, behavioral, and health outcomes. Nevertheless, the critical roles of parenting and the family dynamics cannot be minimized. There is convincing evidence that parenting behaviors profoundly impact the development of positive behaviors and outcomes in youths and adolescents. Parental behaviors implicated im·pli·cate
tr.v. im·pli·cat·ed, im·pli·cat·ing, im·pli·cates
1. To involve or connect intimately or incriminatingly: evidence that implicates others in the plot.
2. include appropriate parental monitoring, supervision, and communication, low family conflict and disorganization, low parental stress and depression, healthy parent-child bonding and positive discipline methods (evidenced by interactional behaviors associated with warmth, patterns of punishment and reward, verbal techniques, appropriate direction, and control). For example, although evidence suggests that peer influence is pivotal in initiating negative behaviors in youths and adolescents, parental disapproval has a major suppressive sup·pres·sive
Tending or serving to suppress.
Adj. 1. suppressive - tending to suppress; "the government used suppressive measures to control the protest" effect for alcohol and drug use. Other recent evidence also suggests that a positive family environment, inclusive of inclusive of
Taking into consideration or account; including. positive parent-child relationships, consistent supervision and communication of prosocial and healthy values and expectations, act as major deterrents for youths and adolescents to engage in negative and unhealthy behaviors and are associated with better school performance and psychosocial development psychosocial development Psychiatry Progressive interaction between a person and her environment through stages beginning in infancy, ending in adulthood, which loosely parallels psychosexual development. See Cognitive development. .
A 2003 report from the National Academy of Sciences revealed that between 1970 and 2000 the maternal labor force rose from 38 to 68%. Moreover, this trend reflects a broad range of demographics and circumstances including first-time and never-married mothers, mothers of all income brackets, education levels, race, ethnicity, or place of residence. With parents spending substantial amounts of their daily lives at the workplace, and with fewer supports from a second parent or extended family members, coupled with high adolescent and youth involvement in negative and unhealthy behaviors, parents need to know how to parent effectively. Parenting effectively includes, besides the aforementioned factors, an understanding of the concept of healthy adolescence and normative development, how to assess the status of their adolescent child in terms of his or her health trajectory, how to facilitate healthy development and foster the adoption of positive health behaviors, how to access resources and support for themselves and their adolescent when there is a problem. Adolescent health behaviors include, but are not limited to, nutrition/dietary practices, physical activity, weight control, drug, alcohol, and tobacco use, injuries and violence, and sexual activity.
In 2004, > 40 million U.S. residents were classified as adolescents ranging in age from 10-19 years. This represents 14% of the U.S. population. Among these, approximately two-thirds of the adolescent population was non-Hispanic and one-third of other racial ethnic identity. Projections indicate that by year 2050, the nation's racial/ethnic minority groups (black, Hispanic, American indian American Indian
or Native American or Amerindian or indigenous American
Any member of the various aboriginal peoples of the Western Hemisphere, with the exception of the Eskimos (Inuit) and the Aleuts. , Asian) will constitute approximately 56% of the adolescent population. While the health status of adolescents differs according to according to
1. As stated or indicated by; on the authority of: according to historians.
2. In keeping with: according to instructions.
3. age, sex, race, and ethnic origin, there is ample documentation suggesting that adolescents, regardless of background, engage in high-risk behavior.
Today, tobacco use constitutes the single leading cause of preventable death in the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. . Epidemiologists estimate that tobacco-related illnesses will be responsible for > 5 million premature deaths among persons age 17 and under who begin to use tobacco products in 1995. Data from the Youth Risk Behavior Surveillance System (YRBS YRBS Youth Risk Behavior Survey ) noted that 80% of individuals who use tobacco began before age 18. Further, data from the 2004 Monitoring the Future Monitoring the Future is an annual survey given to 50,000 8th, 10th and 12th graders in the United States to determine drug use trends and patterns. The survey started in 1975, with 12th graders. It was expanded in 1991 to include 8th and 10th graders as well. (MTF (1) (Modulation Transfer Function) A measurement of monitor sharpness. MTF compares the contrast ratio between alternating black and green lines that are one pixel thick. ) Survey of 50,000 students show that 9% of 8th graders reported smoking in the prior 30 days, along with 16% of 10th graders and 25% of 12th graders. Some important subgroup differences have been observed, particularly for smoking. Students who plan to complete a four-year college education are much less likely to smoke than those who do not have such plans. Youth living in rural areas and small town areas are considerably more likely to smoke than those living in metropolitan areas. Students with more educated parents are less likely to smoke, particularly at young ages.
Poor dietary habits or improper eating habits have been linked to the development of coronary heart disease coronary heart disease: see coronary artery disease.
coronary heart disease
or ischemic heart disease
Progressive reduction of blood supply to the heart muscle due to narrowing or blocking of a coronary artery (see atherosclerosis). , cancer, diabetes, osteoporosis, hypertension, and obesity. Although childhood obesity childhood obesity Public health Overweight in a child, an average BMI of ≥ 85% for age and sex; ≥ 95% for age and sex is very obese. See Body-mass index, Obesity. Cf Adult obesity. has been a longstanding public health problem, recent increases have raised the level to epidemic proportions among U.S. children. A 2005 IOM IOM
See: Index and Option Market report estimated that approximately 9 million children over 6 years of age were overweight. Among children 6 to 19 years, 31% were at risk for overweight or overweight, and 16% were overweight (BMI BMI body mass index.
body mass index
Body mass index (BMI)
A measurement that has replaced weight as the preferred determinant of obesity. > 95th percentile for age growth charts). These findings, based upon measured weight and height, reflect a substantial and alarming increase in childhood obesity over the past two decades. Further, the current increase is most prominent among non-Hispanic black and Mexican-American children, with the increase in these groups at more than > 10% over the last two decades. For example, for non-Hispanic black and Mexican-American adolescents, overweight prevalence increased from 13.4 to 23.6% and from 13.8 to 23.4%, respectively. Despite recommendations for a healthier diet, recent data show that the usual diet of today's adolescents includes foods high in saturated fat saturated fat, any solid fat that is an ester of glycerol and a saturated fatty acid. The molecules of a saturated fat have only single bonds between carbon atoms; if double bonds are present in the fatty acid portion of the molecule, the fat is said to be , high in calorie-dense foods, and low in fruit and vegetable consumption.
Similarly, inadequate physical activity contributes to a variety of adverse health conditions and consequences. In contrast, regular physical activity has been associated with increased psychological and mental well-being, improved cardiovascular health, and proper weight maintenance. Physical activity declines during the transition from childhood through adolescence. The National Growth and Health Studies found 34% decline in physical activity in youth during this transitional period from 10 to 18 years. The decline is more dramatic in girls and in African-American youth. Data from the Youth Risk Behavior Surveillance Survey (YRBS) found that vigorous physical activity declines about 30% between grades 9 and 12. Thus, the decline in physical activity begins early, about the time of entry into middle school, and continues throughout adolescence.
This decline in physical activity may contribute to the recent increases in obesity among adolescents. Physical inactivity physical inactivity A sedentary state. Cf Physical activity. during adolescence may later result in obesity during adulthood. Healthy People 2010 and the Dietary Guidelines dietary guidelines Cardiology A series of dietary recommendations from the Nutrition Committee of the Am Heart Assn, that promote cardiovascular health. See Caloric restriction, food pyramid, French paradox. for America recommend that adolescents engage in physical activity that promotes cardiovascular fitness cardiovascular fitness Fitness A benchmark of a subject's cardiovascular and respiratory 'reserve', assessed by exercise testing; improved CF ↓ risk of acute MI. See Aerobic exercise, Exercise, MET, Thallium stress test, Vigorous exercise. Cf Anaerobic exercise. most days of the week for a minimum of [greater than or equal to] 60 min or more per occasion.
With respect to substance abuse, the use of alcohol and other drugs was among the four risk behaviors of concern among adolescents during the 1990s and continue to be major public health concerns today. Underage drinking particularly is a major public health problem. Alcohol is the drug of choice for youth, and, on average, adolescents tend to drink more per occasion than adult drinkers, with binge drinking binge drinking An early phase of chronic alcoholism, characterized by episodic 'flirtation' with the bottle by binges of drinking to the point of stupor, followed by periods of abstinence; BD is accompanied by alcoholic ketoacidosis–accelerated lipolysis and (four or more drinks for women, five or more for men) especially problematic. In a 2003 IOM and NRC NRC
1. National Research Council
2. Nuclear Regulatory Commission
Noun 1. NRC - an independent federal agency created in 1974 to license and regulate nuclear power plants report, it was revealed that nearly half of high school seniors reported using alcohol 30 days prior to being surveyed; this compares to 27% for tobacco and 22% for marijuana. Most adolescents being surveyed reported starting using alcohol or other drugs before entering high school. An additional troubling finding is that the proportion of underage drinkers has remained virtually unchanged from 2002. The use of alcohol and other drugs is associated with a variety of adverse consequences such as violence, injuries in car crashes, and premature death. In addition, national survey data show that early initiation of alcohol use is associated with elevated risk for later alcohol dependency. As such, the IOM and NRC concluded new interventions such as those targeting parents and other adults are warranted. Finally, according to the 2004 MTF survey, several illicit drugs (such as marijuana, ecstasy, and amphetamines Amphetamines
Sympathomimetic amines; sometimes called speed; synthetic chemicals that stimulate the central nervous system.
Mentioned in: Weight Loss Drugs
amphetamines ) have shown modest declines, while other drugs have been showing signs of increasing use. The main areas of concern that are raised by the 2004 MTF findings are the increasing use of inhalants inhalants,
n.pl 1. chemical vapors that are inhaled for their mind-altering effects.
2. in herbology, volatile herbal compounds that are delivered by holding a soaked pad to the nose and mouth, by placing the herbs in steaming water, or by 8th graders, and the continued high rates of abuse of prescription pain killers in each grade.
Responsible sexual behavior has been identified as a leading health indicator in Healthy People 2010 with specific behavior objectives aimed at increasing the proportion of adolescents who abstain from abstain from
verb refrain from, avoid, decline, give up, stop, refuse, cease, do without, shun, renounce, eschew, leave off, keep from, forgo, withhold from, forbear, desist from, deny yourself, kick ( sexual intercourse sexual intercourse
or coitus or copulation
Act in which the male reproductive organ enters the female reproductive tract (see reproductive system). or use condoms if sexually active. Adolescents who engage in early sexual behaviors are at an increased risk of sexually transmitted diseases Sexually transmitted diseases
Infections that are acquired and transmitted by sexual contact. Although virtually any infection may be transmitted during intimate contact, the term sexually transmitted disease is restricted to conditions that are largely including HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. infection as well as unintended pregnancy, and, for drinking teens, possibly conceiving a child afflicted af·flict
tr.v. af·flict·ed, af·flict·ing, af·flicts
To inflict grievous physical or mental suffering on.
[Middle English afflighten, from afflight, with fetal alcohol spectrum disorder Fetal Alcohol Spectrum Disorders (FASD) describes a continuum of permanent birth defects caused by maternal consumption of alcohol during pregnancy, which includes, but is not limited to Fetal alcohol syndrome (FAS). (FASD FASD Fetal Alcohol Spectrum Disorder
FASD Fleetwood Area School District (Pennsylvania)
FASD Florida Association for Staff Development
FASD Finnish Association of Sports for the Disabled
FASD Finnish Association of Securities Dealers ). Recent estimates (2005) are that over half of all high school students engage in some form of sexual activity. However, national trends have also showed that the prevalence of sexual experience among adolescents decreased 8% while the prevalence of multiple partners decreased 13%.
Currently, motor vehicle and firearm-related injuries are the leading cause of death for adolescents. The high death rates from motor vehicle injuries are partly due to high-risk behaviors among adolescents (e.g., drunken driving, the nonuse of seat belts). Motor vehicle death rates were higher for male adolescents, non-Hispanic white, American-Indian and Alaskan Native adolescents and lower among non-Hispanic black, Hispanic, Asian and Pacific Islander Pacific Islander
1. A native or inhabitant of any of the Polynesian, Micronesian, or Melanesian islands of Oceania.
2. A person of Polynesian, Micronesian, or Melanesian descent. See Usage Note at Asian. adolescents. Death rates from firearm injuries increase with age with highest rates for males 19 years of age or older. Similarly, death rates from firearm injuries for females 19 years or older are 10 times higher when compared with firearm death injuries for females age 11-18 years. Nevertheless, firearm-related death rates are strikingly higher for black adolescents when compared to adolescents from other racial/ethnic minority groups. These two leading causes of death are identified as high priority areas in Healthy People 2010.
In summary, scientific evidence suggests that interventions targeting parents and families can exert powerful influence and are cost-effective in reducing or eliminating health risk behaviors among adolescent children. Continued research is needed to decrease the numbers of adolescents engaging in high-risk behaviors, thus, reducing and ameliorating the short and long-term consequences associated with these behaviors. Further, many of these behaviors are interrelated in·ter·re·late
tr. & intr.v. in·ter·re·lat·ed, in·ter·re·lat·ing, in·ter·re·lates
To place in or come into mutual relationship.
in and thus may be amenable to interventions that address multiple risk behaviors simultaneously. For example, research has shown that youths and adolescents who engage in heavy drinking
n the position of an individual on a socio-economic scale that measures such factors as education, income, type of occupation, place of residence, and in some populations, ethnicity and religion. ), family dynamics, geographic location, and other special needs that may impact the promotion of adolescent behavior and health outcomes. Psychosocial mediators of health behavior such as parental cultural beliefs and values, and parental self-efficacy must also be considered. Applications in response to this announcement should be grounded in theory and should reflect the current literature on parenting and its effects on adolescent risk behaviors. Applications should identify constructs to be measured, review the relevant theoretical literature, and clearly identify research aims and design, along with the strengths and limitations of the proposal. Outcome measures should have sound psychometric psy·cho·met·rics
n. (used with a sing. verb)
The branch of psychology that deals with the design, administration, and interpretation of quantitative tests for the measurement of psychological variables such as intelligence, aptitude, and properties and should be age and language appropriate. The cultural and socioeconomic status of participants should also be considered.
The following are potential areas of research related to this program announcement. These examples are not listed in any priority order and are not to be viewed as exhaustive or an exclusive listing of potential areas. Suitable topics for research include, but are not limited to, the following: 1) interventions that incorporate protective factors that aid in improving parenting practices and preventing youth and adolescents from engaging in multiple risky behaviors; 2) interventions that focus on modifying parental practices to improve diet and physical activity and prevent excessive weight gain in normal weight youth and/or reduce rate of weight gain in overweight youth; 3) interventions testing the effects of modifying parental psychosocial factors (e.g., parental self-efficacy) on diet and physical activity behaviors with the goal of controlling childhood obesity;, 4) biobehavioral descriptive or intervention studies intervention studies,
n.pl the epidemiologic investigations designed to test a hypothesized cause and effect relation by modifying the supposed causal factor(s) in the study population. that elucidate and incorporate the physiological, psychological, socioeconomic, emotional, environmental, cultural, and genetic factors that influence parenting practices and health compromising and or health promoting behaviors among youths and adolescents; 5) innovative intervention studies devoted to enhancing parent self-efficacy, competence, and skill development to support the initiation and or maintenance of youth and adolescent health promoting behaviors; 6) intervention studies using community-based approaches to facilitate improved parenting practices and health promotion/ risk reduction behaviors in youth and adolescents in rural and urban settings. Community interventions using indigenous community infrastructures are relevant, as is the fostering of partnerships between academic researchers and community health care providers. Reaching populations outside of traditional channels (such as families involved with social service agencies, the juvenile justice or foster care systems) may identify parents and children with clusters of risk factors; 7) prevention/intervention strategies that target parents or caregivers of youth and adolescents with HIV/AIDS HIV/AIDS Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome ; 8) prevention/intervention strategies that target families with special needs, such as parents or caregivers of youths and adolescents with chronic illness or developmental disabilities developmental disabilities (DD),
n.pl the pathologic conditions that have their origin in the embryology and growth and development of an individual. DDs usually appear clinically before 18 years of age. ; 9) studies investigating the effects and interrelationships among psychosocial and environmental factors (e.g., single parenting, sex, age, poverty, geographic location), and the adoption of high-risk behaviors or health-promoting behaviors among youth and adolescents; 10) intervention studies that facilitate parent/child communication and bonding in situations where child/parent temperaments conflict leading to difficulties with discipline and subsequent risk behaviors; 11) prevention studies that incorporate motivational strategies for behavior change and skills development for behavioral control for children (and parents); 12) culturally and linguistically appropriate intervention studies that incorporate the stages of cognitive and normative development in families having diverse backgrounds; 13) unique and culturally sensitive interventions to promote healthier dietary intake and adequate activity in minority parents and their youth and adolescents; 14) interventions to reduce the risk of poor outcomes for children in families affected by alcohol use disorders. This can include intervening with parents whose alcohol use is impeding effective caregiving; youth with experimental or established alcohol use patterns who need improved parental attention; parents or youth with neurological damage and/or behavioral and cognitive deficits resulting from prenatal alcohol exposure who are at high risk for future social, psychological, and psychiatric problems; 15) prevention strategies targeting a broad range of patenting factors, focusing on family system changes during late childhood and adolescence; 16) intervention strategies focusing on multiple risk or protective parenting and caregiver practices in vulnerable families (such as single mothers and fathers, grandparent(s) as parents/caregivers, low-income, migrant, parents with chronic illnesses such as depression or HIV/AIDS, parents with a history of substance use or abuse, etc.) that contribute to or protect against negative youth and adolescent and health behavior outcomes; 17) testing of prevention strategies, known to be effective with early and middle childhood, adapted for use with older youth and adolescents; 18) work-site based intervention studies to facilitate improved parenting practices and health promotion/risk reduction behaviors in youths and adolescents in rural and urban settings; 19) biobehavioral or intervention strategies that represent improved or new methods (e.g., adaptation of or novel technology) and/or measures that are culturally appropriate; 20) prevention interventions that target parenting practices and training in drug education in combination with youth and adolescent drug abuse prevention strategies, during key transition points, such as the transition to middle school or high school; 21) novel or adapted drug abuse prevention programs that are tailored to racial and ethnic minority groups, and are culturally appropriate and theoretically based.
This funding opportunity will use the NIH Developmental/Exploratory (R21) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project.
This funding opportunity uses just-in-time concepts. It also uses the modular budget format described in the PHS (Personal Handyphone System) A TDMA-based cellular phone system introduced in Japan in mid-1995. Operating in the 1880-1930 MHz band, PHS uses microcells that cover an area only 100 to 500 meters in diameter, resulting in lower equipment costs but requiring more base 398 application instructions (see http://grants.nih.gov/grants/funding/modular/ modular.htm).
The PHS 398 application instructions are available at http://grants.nih.gov/grants/funding/phs398/ phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, 301-435-0714 (telecommunications for the hearing impaired: TTY (TeleTYpewriter) See teletypewriter and TDD/TTY.
(hardware) tty - /tit'ee/ (ITS pronunciation, but some Unix people say it this way as well; this pronunciation is not considered to have sexual undertones), /T T Y/
2. 301-451-0088) or by e-mail: GrantsInfo@nih.gov.
Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System The Data Universal Numbering System, abbreviated as DUNS or D-U-N-S is a system developed and regulated by Dun & Bradstreet (D&B) which assigns a unique numeric identifier to a single business entity. This numeric identifier is then referred to as a DUNS number. (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling 866-705-5711 or through the web site at http://www.dnb.com/us/. The D&B number should be entered on line 11 of the face page of the PHS 398 form.
The application submission dates for this PA are available at http://grants.nih.gov/grants/funding/ submissionschedule.htm. The complete version of this PA is available at http://grants/nih.gov/grants/ guide/pa-files/PA-06-098
Contacts: Yvonne Bryan, Division of Extramural extramural /ex·tra·mu·ral/ (-mur´il) situated or occurring outside the wall of an organ or structure.
situated or occurring outside the wall of an organ or structure. Activities, National Institute of Nursing Research The National Institute of Nursing Research (NINR), as part of the U.S. National Institutes of Health, supports clinical and basic research to establish a scientific basis for the care of individuals across the life span--from management of patients during illness and recovery, to , 6701 Democracy Boulevard, Suite 710, Bethesda, MD 20892 USA, 301-594-6908, fax: 301-480-8260, e-mail: firstname.lastname@example.org; Lynne M. Haverkos, Behavioral Pediatrics and Health Promotion Research, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B05 Bethesda, MD 20892 USA, 301-435-6881, fax: 301-480-0230, e-mail: email@example.com; Charlotte Pratt, National Heart, Lung, and Blood Institute National Heart, Lung, and Blood Institute,
n.pr established in 1948, this division of the National Institutes of Health is responsible for research and education on cardiovascular, pulmonary, systemic diseases, and sleep disorders. , Division of Epidemiology and Clinical Applications, 6701 Rockledge Drive, Room 8134, Bethesda, MD 20892 USA, 301-435-0382, fax: 301-480-1669, e-mail: firstname.lastname@example.org; Margaret E. Mattson, National Institute on Alcohol Abuse and Alcoholism The National Institute on Alcohol Abuse and Alcoholism (NIAAA), as part of the U.S. National Institutes of Health, supports and conducts biomedical and behavioral research on the causes, consequences, treatment, and prevention of alcoholism and alcohol-related problems. , Division of Treatment and Recovery Research, 5635 Fishers Lane (NIH Mail Stop 9304), Bethesda MD 20892-9304 USA, 301-443-0638, fax: 301-443-8774, e-mail: email@example.com; Belinda E. Sims, Division of Epidemiology, Services and Prevention Research, Prevention Research Branch, National Institute On Drug Abuse The National Institute on Drug Abuse (NIDA) is a United States federal-government research institute whose mission is to "lead the Nation in bringing the power of science to bear on drug abuse and addiction. , 6001 Executive Boulevard, Room 5185, MSC (1) (MSC.Software Corporation, Santa Ana, CA, www.mscsoftware.com) Founded in 1963 by Richard H. MacNeal and Robert G. Schwendler, MSC is the world's largest provider of mechanical computer aided engineering (MCAE) strategies, simulation software and services. 9589, Bethesda, MD 20892-9589 USA, 301-402-1533, fax: 301-443-2636, e-mail: firstname.lastname@example.org. Reference PA-06-098