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Pall Debuts Five New Products for Increased Drug Manufacturing Efficiency at INTERPHEX 2005.


EAST HILLS, N.Y. -- Pall Corporation (NYSE NYSE

See: New York Stock Exchange
:PLL PLL - phase-locked loop ) introduces five innovative technologies aimed at increasing drug manufacturing efficiency through customization and disposability at INTERPHEX 2005 today. The new technologies deliver a combination of benefits that help drug manufacturers enhance throughput and scalability, eliminate time-consuming steps, shorten processing times and reduce labor. By enabling significant time and cost benefits at multiple points within drug production processes, the new products will help meet the needs of the fast-growing, global biopharmaceuticals industry. The biopharmaceuticals market generated revenues of $45 billion in 2004 and is predicted to reach $98.2 billion by 2011. E[acute accent]"The nature of the biopharmaceutical industry requires constant innovation to address rapidly changing process needs as new classes of drugs are discovered and developed," says Ken Frank, President of Pall BioPharmaceuticals. "The scope of products we are launching at Interphex reinforces our commitment to providing total fluid management across the wide range of biopharmaceutical applications."

E[acute accent]Super-Efficient Chromatography

E[acute accent]The Company is unveiling an innovative chromatography technology for super-efficient capture of large molecules, especially used to develop DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 and virus-based drugs. The Mustang(R) XT5000 capsule answers the industry's need for greater throughput, superior binding capacity and fast processing in a capsule format for use in a wider range of process chromatography applications. E[acute accent]This next-generation ion exchange ion exchange
n.
A reversible chemical reaction occurring between an insoluble solid and a solution during which ions may be interchanged, used in the separation of radioactive isotopes.
 membrane capsule extends Mustang chromatography's uses beyond removal of contaminants such as DNA, viruses, endotoxins and host cell proteins. It enables super-efficient capture of large molecules, a growing need with the increasing development of new drugs and therapies that utilize recombinant proteins, plasmids and other viral vectors and blood plasma fractions blood plasma fraction
n.
The components of blood plasma that are separated by electrophoresis or a similar analytical technique.
. With the ability to process large fluid volumes 30 times faster than traditional chromatography resins during capture and polishing steps, the new capsule brings the benefits of Mustang technology to both ends of the process chromatography spectrum.

E[acute accent]Single-Use Technologies

E[acute accent]The Company is also introducing two new additions to its growing portfolio of technologies for disposable processing. It is launching the first customizable Tangential Flow Filtration Tangential Flow Filtration (TFF) is a separation technique that uses membrane systems to purify proteins. It recirculates the retentate across the membrane surface, which minimises the fouling of the membrane.  (TFF TFF The Final Frontier (Star Trek movie)
TFF Tribeca Film Festival
TFF Tears for Fears (band)
TFF The Transnational Foundation for Peace and Future Research
TFF Tangential Flow Filtration
) system that incorporates single-use components for downstream processing applications. The new mobile TFF system will help manufacturers realize significant time, cost and safety benefits in biopharmaceutical production. E[acute accent]The Kleenpak(TM) Connector, a new single-use device, enables aseptic aseptic /asep·tic/ (-tik) free from infection or septic material.

a·sep·tic
adj.
Of, relating to, or characterized by asepsis.
 connections to be made instantly, in a matter of seconds. Capable of withstanding autoclave autoclave

Vessel, usually of steel, able to withstand high temperatures and pressures. The chemical industry uses various types of autoclaves in manufacturing dyes and in other chemical reactions requiring high pressures.
 steam temperatures up to 130 degrees centigrade centigrade /cen·ti·grade/ (sen´ti-grad) having 100 gradations (steps or degrees); see under scale.

cen·ti·grade
adj.
Celsius.
 (130 degrees C), it provides process efficiency for an even broader range of biopharmaceutical applications. It is the only aseptic connector that does not require laminar flow hoods or other capital equipment to make a connection. The disposable device also promotes more efficient manufacturing practices by eliminating the need for cleaning and cleaning validation.

E[acute accent]High Performance Depth Filtration

E[acute accent]Responding to the growing need for higher performance depth filtration, Pall is also launching the SUPRAdisc(TM) HP depth filter. The new filter enables more efficient cell harvest and clarification steps for drug processing with an expanded range of pharmaceutical grade filtration media. The SUPRAdisc HP filter offers higher dirt holding capacity and longer service life compared to other depth filtration systems, addressing the industry's needs to remove the widely varying particle sizes inherent in biotechnology and pharmaceutical drug production.

E[acute accent]Process Simplification

E[acute accent]Also at INTERPHEX 2005, the Company unveils its latest version of operating software that simplifies operation of complex systems. By allowing engineers to make process changes to TFF systems themselves, this software option avoids time-consuming and costly steps associated with reprogramming Reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development[1]. After fertilization some cells of the newly formed embryo migrate to the germinal ridge and will eventually become the germ cells  and revalidation. Its modular design, user-friendly touch screen and pull-down menu further simplify control of critical biopharmaceutical processes.

E[acute accent]About Pall Corporation

E[acute accent]Pall Corporation is the global leader in the rapidly growing field of filtration, separations and purification. Pall's business is organized around two broad markets: Life Sciences and Industrial. The Company provides leading-edge products to meet the demanding needs of customers in biotechnology, pharmaceuticals, transfusion medicine transfusion medicine Blood banking A subspecialty of clinical pathology or internal medicine which is involved in Pt management through administration of blood cells and blood products including fresh-frozen plasma and cryoprecipitate; TM specialists are versant in , semiconductors, water purification, aerospace and broad industrial markets. Total revenues for fiscal 2004 were $1.8 billion. The Company headquarters are in East Hills, New York East Hills is a village in Nassau County, New York on the North Shore of Long Island. It is considered part of the Greater Roslyn area, which is anchored by the Village of Roslyn. As of the United States 2000 Census, the village population was 6,842.  with extensive operations throughout the world.

E[acute accent]Forward-Looking Statement forward-looking statement

A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections.
 

E[acute accent]This release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. These statements are based on current Company expectations and are subject to risks and uncertainties, which could cause actual results to differ materially. Such risks and uncertainties include, but are not limited to: fluctuations in foreign currency exchange rates; regulatory approval and market acceptance of new technologies; changes in product mix and product pricing and in interest rates and cost of raw materials; the Company's success in enforcing its patents and protecting its proprietary products and manufacturing techniques and its ability to achieve the savings anticipated from its cost reduction initiatives; global and regional economic conditions and legislative, regulatory and political developments; and domestic and international competition in the Company's global markets. Additional information regarding these and other factors is available on the Web at www.pall.com and is included in the Company's reports filed with the U.S. Securities and Exchange Commission. Copies of such reports can be obtained, without charge, at www.sec.gov.

E[acute accent]Editor's Note:

E[acute accent]--Pall's new products are on display at Booth #1741 at Interphex 2005, Jacob K. Javits Convention Center Jacob K. Javits Convention Center is a large convention center on the west side of Manhattan in New York City. It was designed by architects I. M. Pei and partners. The revolutionary space frame structure was built in 1986 and named for New York Senator Jacob K.  in New York City New York City: see New York, city.
New York City

City (pop., 2000: 8,008,278), southeastern New York, at the mouth of the Hudson River. The largest city in the U.S.
, April 26-28, 2005.

E[acute accent]--Press Conference Luncheon at Interphex 2005 will be held at 12:00 noon on Wednesday, April 27 in room #4A02.

E[acute accent]--Pall executives are available for interviews

E[acute accent]--Photos can be found on www.pall.com/corporate_36594.asp
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Publication:Business Wire
Geographic Code:1USA
Date:Apr 26, 2005
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