POZEN Presents Data on PN 100 Combination Product--Designed to Help Prevent NSAID-Induced Gastric Complications; Proof-of-Concept Study Presentation at American College of Gastroenterology (ACG) Annual Meeting.

HONOLULU & CHAPEL HILL, N.C. -- POZEN Inc. (NASDAQ: POZN) is presenting key data from its PN 100 proof-of-concept study today during the American College of Gastroenterology Annual Meeting in Honolulu, Hawaii. POZEN's PN product platform, which includes PN 100, consists of combinations of a gastric acid inhibitor and a non-steroidal anti-inflammatory drug (NSAID). These drug candidates may lower the risk of gastrointestinal complications in patients who use NSAID therapy for arthritis and other chronic conditions. POZEN's PN 100 drug candidate is a fixed combination of the proton pump inhibitor (PPI) lansoprazole and the NSAID naproxen, both of which have been used as individual drugs for a number of years.

Dr. James Alexander, POZEN's senior vice president of product development and chief medical officer, is presenting results of a 14-day proof-of-concept study in which volunteers received either PN 100, naproxen alone, or naproxen with a currently marketed once-daily dose of lansoprazole. Dr. Alexander stated, "The key finding of this trial is that PN 100 appears to work very well as evidenced by the fact that PN 100 significantly reduced gastric damage due to naproxen during the study period. This positive effect was evident even in this small proof-of-concept trial."

POZEN's PN drug candidates are being developed for the management of pain and inflammation associated with conditions such as osteoarthritis, one of the most frequent causes of physical disability among adults, affecting an estimated 20 to 30 million people in the United States. Estimates show that by 2030, 20 percent of Americans--about 70 million people--will have passed their 65th birthday and will be at risk of osteoarthritis.

The PN 100 proof-of-concept study presentation slides can be accessed in the Investor Overview section of POZEN's website at www.pozen.com.

About POZEN

POZEN is a pharmaceutical company committed to developing therapeutic advancements for diseases with unmet medical needs where it can improve efficacy, safety, and/or patient convenience. Since its inception, POZEN has focused its efforts primarily on the development of pharmaceutical products for the treatment of migraine. POZEN is also exploring the development of product candidates in other acute and chronic pain and pain-related therapeutic areas. POZEN has a development and commercialization alliance with GlaxoSmithKline. The company's common stock is traded on The Nasdaq Stock Market under the symbol "POZN". For detailed company information, including copies of this and other press releases, see POZEN's website: www.pozen.com.

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