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PE Biosystems' ABI PRISM 3700 DNA Analyzer Receives Wide Acceptance.


FOSTER CITY, Calif.--(BW HealthWire)--March 25, 1999--PE Biosystems, a division of Perkin-Elmer (NYSE NYSE

See: New York Stock Exchange
: PKN PKN Polish Committee for Standardization
PKN Protestantse Kerk Van Nederland (Dutch church) 
), has received more than 500 orders for its new ABI Abi (ā`bī) [short for Abijah], in the Bible, King Hezekiah's mother.


(Application Binary Interface) A specification for a specific hardware platform combined with the operating system.
 PRISM(R) 3700 DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 Analyzer. Included in this number are 36 additional systems recently ordered by The Sanger Centre Sanger centre is a genomics research centre established by UK government. It is one of the first and largest genomics center in the world. Its name is after Frederick Sanger who has received two Nobel prizes for his work on protein and DNA sequencing.  in Cambridge, England, one of the instrument's test sites, and the previously announced order for 230 units from Celera Genomics. Four months after shipments of the 3700 began, there are more than 50 instruments operating in 15 test sites around the world.

Commenting on the significance of the newly introduced sequencer See MIDI sequencer.

(music) sequencer - Any system for recording and/or playback of music via a programmable memory which stores music not as audio data, but as some representation of notes.
 to the human genome The human genome is the genome of Homo sapiens, which is composed of 24 distinct pairs of chromosomes (22 autosomal + X + Y) with a total of approximately 3 billion DNA base pairs containing an estimated 20,000–25,000 genes.  initiative, Tony White, chairman, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Perkin-Elmer, said, "As the pace of genomic sequencing genomic sequencing  

The sequencing of the entire genome of an organism.

A Closer Look The technique that allows researchers to read and decipher the genetic information found in the DNA of anything from bacteria to plants to animals is
 accelerates throughout the world, we are rapidly nearing an era in which genomic information will have a profound effect. The science of biology and its applications to medicine, agriculture, and other fields is being fundamentally transformed by creative scientists armed with new technologies. We are pleased to be contributing to the advancement of these fields through our innovative technologies."

Michael W. Hunkapiller, Ph.D., senior vice president of Perkin-Elmer and president of its PE Biosystems Division, added, "We are very pleased with the success of the 3700. Its early acceptance and continued strong demand are evidence that this system provides a significant advance in automation for production-scale sequencing and genotyping. More than half of our test sites have requested shipments of additional systems."

The Sanger Centre's Jane Rogers, Ph.D., Human Sequencing and Mapping project manager, remarked, "Automation of so many of the steps required by other systems makes the 3700 an attractive option for high-throughput sequencing. Since it takes only 10-15 minutes of operator time to run four plates of samples, many of our resources can be re-deployed to support this throughput increase in other areas of the production process." The 3700 represents a 60 percent increase in throughput compared with the existing, commonly used technology - combined with a seven-fold decrease in labor required.

Operation of the 3700 is consistent from run to run, and equal or fewer lane failures occur than with previous capillary and slab gel sequencers. The instrument can sequence plasmid, BAC BAC
abbr.
blood alcohol concentration
 end, and double-stranded templates and can be used with PE Biosystems' BigDye Primer and Terminator chemistries and Linkage Mapping Set Version 2 fragment analysis chemistries as well as with various other chemistries.

PE Biosystems is now in the final stages of development on the 3700. Now that data are available from the various test sites, finishing touches can be put on basecalling and mobility algorithms, which will be optimized for length of read. Development and optimization do not end with the initial release of the product. After the initial release, as with all DNA analyzers developed by PE Biosystems, the 3700's performance will continue to be enhanced over time with updates to software and chemistry.

The Perkin-Elmer Corporation currently comprises three operating divisions. The PE Biosystems Division, with sales of $922 million during fiscal 1998, supplies instrument systems, reagents, software, and related services to the life science industry and research community. The ABI PRISM(R) 3700 DNA Analyzer includes patented technology licensed from Hitachi, Ltd. as part of a strategic partnership between Perkin-Elmer and Hitachi, Ltd., as well as patented technology of Perkin-Elmer. The Analytical Instruments Division, which the Company has entered into an agreement to sell, had sales of $609 million during fiscal 1998 and is a leader in supplying a broad range of instruments to the pharmaceutical, environmental, food, chemical, petrochemical, and related industries. Celera Genomics, a newly formed business unit, intends to become the definitive source of genomic and related medical information. Headquartered in Connecticut, Perkin-Elmer had revenues of more than $1.5 billion in fiscal 1998 and employs more than 7,000 people worldwide. Information about Perkin-Elmer is available on the World Wide Web at http://www.perkin-elmer.com or by phoning (800) 762-6923.

Certain statements in this press release are forward-looking. These may be identified by the use of forward-looking words or phrases such as "believe," "expect," "anticipate," "should," "planned," "estimated," and "potential," among others. These forward-looking statements are based on Perkin-Elmer's current expectations. The Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995 provides a "safe harbor Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
" for such forward-looking statements. In order to comply with the terms of the safe harbor, Perkin-Elmer notes that a variety of factors could cause actual results and experience to differ materially from the anticipated results or other expectations expressed in such forward-looking statements. The risks and uncertainties that may affect the operations, performance, development, and results of Perkin-Elmer's businesses include but are not limited to (1) dependence on new products; (2) sales dependent on customers' capital spending capital spending

Spending for long-term assets such as factories, equipment, machinery, and buildings that permits the production of more goods and services in future years.
 policies and government-sponsored research; (3) claims for patent infringement patent infringement n. the manufacture and/or use of an invention or improvement for which someone else owns a patent issued by the government, without obtaining permission of the owner of the patent by contract, license or waiver. ; (4) significant overseas operations; (5) future growth strategy; (6) uncertainty of success of Year 2000 compliance; (7) earthquakes; and (8) other factors that might be described from time to time in Perkin-Elmer's filings with the Securities and Exchange Commission.

Editors note: This release and a supplementary product backgrounder that further describes the technical features of the 3700 DNA Analyzer are also available on the World Wide Web at http://www.noonanrusso.com.
COPYRIGHT 1999 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1999, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Mar 25, 1999
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