PDS BIOTECHNOLOGY LICENSES MERCK EPROVA'S DOTAP CHLORIDE.PDS (1) (Processor Direct Slot) A single expansion slot on certain, early Macintosh models that was used to connect high-speed peripherals as well as additional CPUs. Providing a channel directly to the CPU, the PDS coexisted with NuBus slots on some models. Biotechnology, Indianapolis, has obtained an exclusive license from Merck Eprova AG to utilize Merck Eprova's proprietary chiral chi·ral
Of or relating to the structural characteristic of a molecule that makes it impossible to superimpose it on its mirror image.
chi·ral lipid DOTAP Chloride in Versamune(TM)-HPV and other products in development based on the Versamune(TM) technology. The use of enantiomerically pure DOTAP Chloride shows enhanced adjuvant adjuvant /ad·ju·vant/ (aj?dbobr-vant) (a-joo´vant)
1. assisting or aiding.
2. a substance that aids another, such as an auxiliary remedy.
3. activity compared to the racemate racemate
Mixture of equal quantities of two enantiomers, substances whose molecular structures are mirror images of one another (see isomer). The two enantiomers rotate polarized light through opposite angles, canceling each other out so that the racemic mixture has . Merck Eprova AG will be providing enantiomerically pure DOTAP Chloride manufactured under cGMP for use in clinical and commercial drug products developed with PDS Biotechnology's Versamune(TM) nanoparticle technology. PDS Biotechnology will own the intellectual property rights to products incorporating the chiral DOTAP lipids for immunotherapeutic applications.
Versamune(TM)-HPV is an immunotherapy drug which has demonstrated significant promise in curing HPV HPV human papillomavirus.
human papilloma virus
Human papilloma virus (HPV) infection and HPV-related cancer in preclinical animal and human model studies. Cancers caused by infection with the human papilloma virus human papilloma virus
n. Abbr. HPV
A DNA virus of the genus Papillomavirus, certain types of which cause cutaneous and genital warts in humans, including condyloma acuminatum. (HPV) include cervical, head and neck and anal cancers. No cures exist for these cancers. Based on promising in vivo and in vitro efficacy data, PDS Biotechnology has been awarded grants by the US National Institutes of Health/National Cancer Institute to develop Versamune(TM)-HPV and Versamune(TM)-Melanoma. Versamune(TM)-Melanoma is being developed to treat melanoma, which is the most aggressive form of skin cancer.
PDS Biotechnology's Versamune(TM) nanotechnology facilitates the uptake of disease-associated protein and peptide antigens by the antigen-presenting cells of the immune system. Simultaneously it acts as a strong immune system activator (adjuvant) without the inflammatory side effects induced by current adjuvants. The result is simple, safe and cost effective nanotechnology-based drugs and vaccines that induce effective eradication of the specific cells infected with, or expressing the particular protein formulated with Versamune(TM).
PDS Biotechnology Corporation is an Indiana-based biotechnology company applying the company's proprietary Versamune(TM) nanotechnology drug platform technology to the development of safe and potent immunotherapies to prevent and to treat cancer and diseases caused by infectious agents.
For more information, visit http://www.pdsbiotech.com or call 513/807-6840.
Merck Eprova AG (http://www.merckeprova.com), located in Schaffhausen, Switzerland, is a wholly owned subsidiary Wholly Owned Subsidiary
A subsidiary whose parent company owns 100% of its common stock.
In other words, the parent company owns the company outright and there are no minority owners. of Merck KGaA located in Darmstadt, Germany. Merck Eprova AG specializes in the development and production of cGMP grade, highly purified and characterized Drug Delivery Compounds such as cationic cationic
having qualities dependent on having free cations available.
are wetting agents that disrupt or damage cell membranes, denature proteins and inactivate enzymes. lipids, PEGs, PEG-lipids, and phospholipids. In addition Merck Eprova AG is a centre of excellence for reduced folates in the pharmaceutical and nutritional field and the world's leading supplier of reduced folates.