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Ottawa panel evidence-based clinical practice guidelines for therapeutic exercises and manual therapy in the management of osteoarthritis: appendix.


Appendix 1.

Previous Evidence-Based Clinical Practice Guidelines for
Therapeutic Exercises for Osteoarthritis (a)

                  Quality of Published
Author/Year       Evidence                Clinical Recommendations

Philadelphia      Good scientific         Good evidence (grade A) to
  Panel, (36)       evidence (level 1)      include strengthening and
  2001              for therapeutic         stretching exercises alone
                    exercises               for knee OA
ACR, (31) 2000    N/R                     Exercise programs are
                                            recommended to maintain or
                                            improve joint ROM and
                                            periarticular muscle force
AGS, (32) 2001    N/R                     Exercise programs should be
                                            individualized. They are
                                            recommended for controlling
                                            pain, increasing
                                            flexibility, and  improving
                                            muscle force and endurance
APS, (33) 2002    Good-quality evidence   Exercise--ROM, stretching,
                                            stengthening (isometric,
                                            dynamic), aerobic exercise,
                                            and physical activity--is
                                            recommended for pain relief
OPOT, (35) 2000   Good-quality evidence   Exercise programs (stretching
                                            and quadriceps femoris
                                            muscle strengthening;
                                            aerobic exercise, including
                                            walking and swimming; and
                                            and resistance exercises)
                                            are recommended to reduce
                                            pain and to improve
                                            function in patients with
                                            OA of the knee
BM-1, (34) 2003   N/R                     Likely to be beneficial for
                                            pain relief and to improve
                                            function

(a) Interventions with no data are not exhibited. ACR=American
College of Rheumatology Subcommittee on Osteoarthritis Guidelines,
AGS=American Geriatrics Society Panel on Exercise and
Osteoarthritis, APS=American Pain Society, OPOT=Ontario Program
for Optimal Therapeutics, BM1=BMJ Books, N/R=not reported,
OA=osteoarthritis, ROM=range of motion.

Appendix 2.

Details of Included Trials (a)

                     Sample
Author/Year          Size           Population Details

Bautch et            RCT            Inclusion criteria: patients
  al, (63) 1997      Total: 30        who met the ACR
                     Gr1: 15          clinical and
                     Gr2: 15          radiographic criteria
                                      for primary OA of the
                                      knee; were [greater than
                                      or equal to] 59 y of
                                      age and living
                                      independently, without
                                      physical or medical
                                      problems for which an
                                      exercise program
                                      would be
                                      contraindicated; were
                                      not currently enrolled
                                      in a regular exercise
                                      program; had not
                                      received intra-articular
                                      or systematic steroids
                                      within the past 2 y;
                                      and did not routinely
                                      use NSAIDs

Borjessson et        RCT            Inclusion criteria: patients
  al, (64) 1996      Total: 68        who were aged 55-
                     Gr1: 34          70 y, had medial
                     Gr2: 34          knee OA (grades I-III)
                                      based on weight-
                                      bearing radiographs,
                                      were scheduled for
                                      surgery, had unilateral
                                      symptoms, and had no
                                      symptoms in hip or
                                      ankle

Deyle et al, (30)    RCT            Inclusion criteria: patients
  2000               Total: 83        who (1) had knee
                     Gr1: 42          pain, were aged [less than or
                     Gr2: 41          equal to] 38 y, and had bony
                                      enlargement; (7 had
                                      knee pain, were aged
                                      [less than or equal to] 39 y, and
                                      had morning stiffness for
                                      more than 30 min and
                                      bony enlargement; (3)
                                      had knee pain,
                                      crepitus on active
                                      motion, morning
                                      stiffness for more than
                                      30 min, and bony
                                      enlargement; or (4)
                                      had knee pain,
                                      crepitus on active
                                      motion, and morning
                                      stiffness for more than
                                      30 min and were
                                      aged [less than or equal to] 38 y

Evcik and            CCT            Inclusion criteria: patients
  Sonel, (47)        Total: 81        with knee OA
  2002               Gr1: 27        Exclusion criteria:
                     Gr2: 28          patients who had
                     Gr3: 26          taken a quadriceps
                                      femoris muscle
                                      exercise program
                                      during the last 6 mo
                                      or who had effusion
                                      on knees, previous
                                      knee replacement
                                      severe cardiovascular
                                      diseases, or grade 4
                                      OA according to
                                      Kellgren and
                                      Lawrence criteria

Fransen et           RCT            Inclusion criteria: patients
  al, (65) 2001      First part:      who were aged [less than or equal
                     Total:           to] 50 y, had experienced
                       126            knee pain most days
                     Gr1: 43          of the past months,
                     Gr2: 40          and had evidence of
                     Gr3: 43          radiographic disease
                     Second         Exclusion criteria:
                       part:          patients who had
                     Total:           intra-articular cortisone
                       121            injections within the
                     Gr1: 62          past 2 mo, lower-limb
                     Gr2: 59          joint arthroplasty,
                                      unstable cardiac
                                      comorbidity
                                      ocluding exercise at
                                      50%-60% of maximal
                                      HR, or other
                                      comorbidiy after gait

Garfinkel et         RCT            Inclusion criteria: patients
  al, (66) 1994      Total: 30        who had OA of the
                     Gr1: 19          distal or proximal
                     Gr2: 11          interpholongeal joints
                                      of the fingers and who
                                      had pain, aching, or
                                      stiffness in the hands;
                                      specific criteria for
                                      inclusion were those of
                                      Altman et al (b)

Gur et al, (67)      RCT            Inclusion criteria: patients
  2002               Total: 23        who had bilateral
                     Gr1: 9           complaints of knee
                     Gr2: 8           OA, who had grade II
                     Gr3: 6           or III OA as judged by
                                      criteria of Kellg ren
                                      and Lawrence based
                                      on weight-bearing
                                      radiographs, and who
                                      did not have any
                                      health problems that
                                      might pose a risk
                                      during the maximal
                                      test and training

Hurley and           CCT            Inclusion criteria: patients
  Scott, (68)        Total: 60        had to fulfill the ACR
  1998               Gr1: 44          criteria for knee OA;
                     Gr2: 16          the predominant
                                      complaint of all
                                      patients was knee
                                      pain; patients who
                                      reported coexistent
                                      mild symptomatic OA
                                      in other joints were
                                      not excluded from the
                                      trial unless the pain
                                      from these other joints
                                      interfered with the
                                      performance of the
                                      assessment procedures

Kovar et al, (69)    RCT            Inclusion criteria: patients
  1992               Total: 92        who were aged [greater than or
                     Gr1: 47          equal to] 40 y; who had a
                     Gr2: 45          documented diagnosis
                                      of chronic, stable,
                                      primary OA of one or
                                      both knee joints in
                                      association with at least
                                      4-mo history ofknee
                                      symptomatic pain
                                      occurring during
                                      weight-bearing
                                      activities (patients who
                                      had multiple joint
                                      involvement, who had
                                      undergone major joint
                                      surgery, or who had a
                                      lower joint prosthesis
                                      also were eligible);
                                      who had radiographic
                                      evidence of primary
                                      OA of one or both
                                      knee joints, as
                                      demonstrated by joint
                                      space narrowing,
                                      marginal spur
                                      formation, or
                                      subchondral cyst
                                      formation; who used
                                      any of the various
                                      common, over-the-
                                      counter NSAIDs [less than
                                      or equal to] 2
                                      days a week; and who
                                      were not participating
                                      in a regular program of
                                      physical activity at the
                                      time of enrollment

Kreindler et         RCT            Inclusion criteria: patients
  al, (70) 1989      Total: 32        with primary diagnosis
                     Gr1: 8           of OA of the knee
                     Gr2: 5
                     Gr3: 10
                     Gr4: 9

Messier et           RCT            Inclusion criteria: patients
  al, (45) 1997      Total:           who (1) were aged
                       103            [greater than or equal
                     Gr1: 33          to] 60 y, (2) had pain
                     Gr2: 34          on most days of the
                     Gr3: 36          month in one or both
                                      knees, (3) showed
                                      radiographic evidence
                                      of knee OA in the
                                      tibiofemoral
                                      compartments of the
                                      painful knee, and (4)
                                      had difficulty with at
                                      least one of the
                                      following activities due
                                      to knee pain--walking
                                      0.4 km, climbing
                                      stairs, getting in and
                                      out of car, rising
                                      from a chair, lifting
                                      and carrying
                                      groceries, getting out
                                      of bed, getting out of
                                      a bathtub, shopping,
                                      cleaning, or self-care

Minor et al, (48)    RCT            Inclusion criteria: patients
  1989               Total:           with current symptoms
                       115            of chronic pain and
                     Gr1: 36          stiffness in involved
                     Gr2: 47          weight-bearing joints;
                     Gr3:32           objective evidence of
                                      joint pain and
                                      crepitation with
                                      PROM; and
                                      documented
                                      roentgenographic
                                      signs of hypertrophic
                                      changes, subchondral
                                      sclerosis, or
                                      nonuniform joint space
                                      narrowing in involved
                                      joints

O'Reilly et          RCT            Inclusion criteria: patients
  al, (71) 1999      Total:           with [less than or equal to 1
                       191            mo of pain in
                     Gr1:             or around the knee on
                       113            most days and any
                     Gr2: 78          pain in the past year

Peloquin et          RCT            Inclusion criteria: patients
  al, (72) 1999      Total:           who (1) were aged
                       124            [less than or equal to] 50 y; (2)
                     Gr1: 59          had no contraindications to
                     Gr2: 65          exercise; (3) were not
                                      absent from city for
                                      more than 2 wk; (4)
                                      had an independent,
                                      non institutional
                                      lifestyle; (5) had no
                                      intra-articular steroid
                                      or viscoelastic device
                                      injections within the
                                      previous 2 mo; (6)
                                      had stable regimen
                                      using analgesics or
                                      NSAIDs for at least 2
                                      wk before the
                                      beginning of the
                                      study; (7) had
                                      diagnosis of minimal
                                      to moderate idiopathic
                                      OA of 1 or both knee
                                      joints; (8) had >15[degrees]
                                      Nixed-flexion deformity;
                                      (9) had >10[degrees] of genu
                                      varum or valgum; and
                                      (10) had no joint
                                      blocking

Penninx et           RCT            Inclusion criteria: patients
  al, (73) 2001      Total:           who (1) were aged
                       250            [less than or equal to] 60
                     Gr1: 82          y; (2) had pain
                     Gr2: 88          in the knee(s) on most
                     Gr3: SO          days of the month; (3)
                                      had difficulty with at
                                      least one of the
                                      following because of
                                      knee pain--walking
                                      0.4 km; climbing
                                      stairs getting in and
                                      out of a car, bath, or
                                      bed; rising from a
                                      chair; or performing
                                      shopping, cleaning, or
                                      self-care activities; and
                                      (4) showed
                                      radiographic evidence
                                      of knee OA

Peterson et          RCT            Inclusion criteria: patients
  al, (74) 1993      Total: 91        who (1) had at least a
                     Gr1: 47          4-mo history of
                     Gr2: 44          smptomatic knee pain
                                      during weight-bearing
                                      activities; 2) had
                                      radiograpnic evidence
                                      of OA of the knee
                                      joint(s), as
                                      demonstrated by joint
                                      space narrowing,
                                      marginal spur formation,
                                      or subchondral cyst
                                      formation; and (3) used
                                      NSAIDs 2 or more days
                                      a week
                                    Exclusion criteria: patients
                                      who were enrolled in a
                                      regular program of
                                      physical exercise at the
                                      time of the pretrial
                                      interview

Petrella, (75)       RCT            Inclusion criteria: patients
  2000               Total:           who were aged >65
                       179            y, had pain in one
                     Gr1: 91          knee on most days,
                     Gr2: 88          had radiographic
                                      evidence of OA in the
                                      tibiofemoral
                                      compartment, and had
                                      difficulties in
                                      performing ADL

Rejeski et           RCT            Inclusion criteria: patients
  al, (76) 1998      Total:           who (1) were aged
                       357            [less than or equal to]
                                      60 y, (2) had pain
                                      on most days of the
                                      month in one or both
                                      knees, (3) had
                                      difficulty with at least
                                      one ADL leg getting
                                      in and out of a car),
                                      and (4) showed
                                      radiograPhic evidence
                                      of knee OA

Rodgers et           CCT            Inclusion criteria: patients
  al, (77) 1998      Total: 20        with unilateral primary
                     Gr1: 10          TKA for OA
                     Gr2: 10

Rogind et            RCT            Inclusion criteria: patients
  al, (78) 1998      Total: 25        who met the ACR
                     Gr1: 12          criteria for OA in the
                     Gr2: 13          knee that they
                                      reported as the most
                                      affected knee with the
                                      radiograph of this
                                      knee rated at least 3
                                      on the Kellgren scale,
                                      and who were
                                      capable of getting
                                      down on the floor and
                                      up again of
                                      independent walking
                                      and transport, and of
                                      taking one flight of
                                      stairs unassisted to
                                      reach the training
                                      facilities

Schilke et           RCT            Inclusion criteria: patients
  al, (79) 1996      Total: 20        who had not
                     Gr1: 10          participated in a
                     Gr2: 10          strength-training
                                      program within the
                                      past 6 mo

Stamm et             RCT            Inclusion criteria: Patients
  al, (80) 2002      Total: 40        who met the ACR
                     Gr1: 20          criteria for hand OA;
                     Gr2: 20          medication with
                                      analgesics or NSAIDs
                                      was allowed during
                                      the study, but had to
                                      remain stable at least
                                      1 mo before and
                                      throughout the study

Suomi and            RCT            Inclusion criteria: patients
  Lindauer, (81)     Total: 30        who were women
  1997               Gr1: 20          aged 45-70 y, had
                     Gr2: 10          been diagnosed with
                                      RA or OA by either a
                                      rheumatologist or an
                                      orthopedic physician,
                                      had current symptoms
                                      of chronic pain and
                                      stiffness in weight-
                                      bearing joints, scored
                                      15 or less on the
                                      AIMS knee/hip scales,
                                      had no medical
                                      condition precluding
                                      increased physical
                                      activity, had not been
                                      involved in an
                                      organized exercise
                                      program for the past 3
                                      mo, had a stable
                                      medication regimen
                                      for at least 3 mo
                                      before entering the
                                      study, and had
                                      medical clearance
                                      through their primary
                                      physician to
                                      participate in the
                                      Arthritis Foundation
                                      Aquatic Program

Topp et al, (42)     RCT            Inclusion criteria: patients
  2002               Total:           with a diagnosis of
                       102            knee OA and a score
                     Gr1: 35          of 5 or more on the
                     Gr2: 32          Western Ontario and
                     Gr3: 35          McMaster Universities
                                      Osteoorthritis Index
                                      pain subscale

van Baar et          RCT            Inclusion criteria: patients
  al, (82) 1998      Total:           with OA of the hip or
                       191            knee according to the
                     Gr1: 93          clinical criteria of the
                     Gr2: 98          ACR

van Baar et          RCT            Inclusion criteria: patients
  al, (83) 2001      Total:           with OA of the hip or
                       200            knee according to the
                     Gr1: 98          clinical criteria of the
                     Gr2:             ACR
                       102

                     Symptom
Author/Year          Duration                 Age (y)

Bautch et            N/A                      69
  al, (63) 1997

Borjessson et        7.5 y                    55-70
  al, (64) 1996

Deyle et al, (30)    N/A                      Gr1:
  2000                                          [bar.X]=59.6,
                                                SD=10.1
                                              Gr2:
                                                [bar.X]=62.4,
                                                SD=9.7

Evcik and            N/A                      Gr1:
  Sonel, (47)                                   [bar.X]=56.3,
  2002                                          SD=6.1
                                              Gr2:=56.9,
                                                SD=6.5
                                              Gr3:
                                                [bar.X]=55.8,
                                                SD=6.9

Fransen et           N/A                      First part:
  al, (65) 2001                               Gr1:
                                                [bar.X]=68.5,
                                                SD=8.7
                                              Gr2:
                                                [bar.X]=65.3,
                                                SD=7.1
                                              Gr3:
                                                [bar.X]=66.1,
                                                SD=10.3
                                              Second part:
                                              Gr1:
                                                [bar.X]=66.7,
                                                SD=10.1
                                              Gr2:
                                                [bar.X]=66.8,
                                                SD=7.5

Garfinkel et         N/A                      52-79
  al, (66) 1994

Gur et al, (67)      N/A                      Gr1: [bar.X]=56,
  2002                                          SD=12
                                              Gr2: [bar.X]=55,
                                                SD=12
                                              Gr3: [bar.X]=57,
                                                SD=9

Hurley and           Gr1: [bar.X]=51 mo,      Gr1: [bar.X]=62,
  Scott, (68)          SD=                      SD=12.0
  1998                 27.75 mo               Gr2: R=61,
                     Gr2: [bar.X]=54 mo,        SD=11.75
                       SD=
                       42.75 mo

Kovar et al, (69)    Gr1: [bar.X]=12 y,       Gr1:
  1992                 SD=12 y                  [bar.X]=70.38,
                     Gr2: [bar.X]=11 y,         SD=9.11
                       SD=11 y                Gr2:
                                                [bar.X]=68.48,
                                                SD=11.32

Kreindler et         N/A                      [bar.X]=67.42,
  al, (70) 1989                                 SD=8.38

Messier et           N/A                      Gr1:
  al, (45) 1997                                 [bar.X]=70.3,
                                                SD=1.3
                                              Gr2:
                                                [bar.X]=67.2,
                                                SD=0.9
                                              Gr3:
                                                [bar.X]=69.2,
                                                SD=1.0

Minor et al, (48)    N/A                      N/M
  1989

O'Reilly et          N/A                      Gr1:
  al, (71) 1999                                 [bar.X]=61.94,
                                                SD=10.01
                                              Gr2:
                                                [bar.X]=62.15,
                                                SD=9.73

Peloquin et          Gr1: [bar.X]=7.92        Gr1:
  al, (72) 1999        y, SD=7.90               [bar.X]=65.64,
                       y                        SD=7.41
                     Gr2: [bar.X]=6.38        Gr2:
                       y, SD=6.05               [bar.X]=66.43,
                       y                        SD=6.39

Penninx et           N/A                      Gr1:
  al, (73) 2001                                 [bar.X]=68.8,
                                                SD=5.2
                                              Gr2:
                                                [bar.X]=69.9,
                                                SD=5.8
                                              Gr3:
                                                [bar.X]=68.5,
                                                SD=5.4

Peterson et          N/A                      69.4
  al, (74) 1993

Petrella, (75)       N/A                      Gr1:
  2000                                          [bar.X]=72.9,
                                                SD=4.5
                                              Gr2:
                                                R=74.6,
                                                SD=5.2

Rejeski et           N/A                      [bar.X]=68.65,
  al, (76) 1998                                 SD=5.50

Rodgers et           N/A                      Gr1: [bar.X]=70,
  al, (77) 1998                                 SD=3.75
                                              Gr2: [bar.X]=65,
                                                SD=8.25

Rogind et            N/A                      Gr1:
  al, (78) 1998                                 [bar.X]=69.3,
                                                SD=8.2
                                              Gr2:
                                                [bar.X]=73.0,
                                                SD=6.5

Schilke et           <10y                     Gr1:
  al, (79) 1996                                 [bar.X]=64.5,
                                                SD=3.75
                                              Gr2:
                                                [bar.X]=68.4,
                                                SD=8

Stamm et             N/A                      Gr1:
  al, (80) 2002                                 [bar.X]=60.5,
                                                SD=8.33
                                              Gr2:
                                                [bar.X]=60.4,
                                                SD=8.43

Suomi and            Gr1: [bar.X]=21.3        Gr1:
  Lindauer, (81)       y, SD=6 y                [bar.X]=59.8,
  1997               GS: [bar.X]=19.0           SD=5.5
                       y, SD=4.5 y            Gr2:
                                                [bar.X]=54.4,
                                                SD=4.75

Topp et al, (42)     N/A                      Gr1:
  2002                                          [bar.X]=60.94,
                                                SD=10.77
                                              Gr2:
                                                [bar.X]=65.57,
                                                SD=10.77
                                              Gr3:
                                                [bar.X]=63.53,
                                                SD=10.75

van Baar et          N/A                      Gr1:
  al, (82) 1998                                 [bar.X]=68.3,
                                                SD=8.4
                                              Gr2:
                                                [bar.X]=67.7,
                                                SD=9.2

van Baar et          N/A                      Gr1:
  al, (83) 2001                                 [bar.X]=68.3,
                                                SD=8.4
                                              Gr2:
                                                [bar.X]=67.7,
                                                SD=9.2

                                                  Comparison
Author/Year          Intervention                 Group

Bautch et            Gr1: Patients                Gr2: Same as Gr1
  al, (63) 1997        participated in 1 h/         plus exercises.
                       wk educational               ROM exercises
                       program consisting of        of trunk and of
                       content related to           upper and
                       health, exercise, and        lower
                     arthritis.                     extremities.
                                                    Then
                                                    individualized
                                                    low-intensity
                                                    walking on
                                                    treadmill,
                                                    beginning at
                                                    3.22 kmyh and
                                                    grade 0,
                                                    increasing by
                                                    1% each
                                                    minute.
                                                    Distances were
                                                    increased
                                                    weekly.

                                                  Joint protection:
                                                    good walking
                                                    shoes, wood
                                                    floor in exercise
                                                    facility, cane on
                                                    the contralateral
                                                    side, and chair
                                                    exercise aimed
                                                    at strengthening
                                                    the quadriceps
                                                    femoris muscle
                                                    group

Borjessson et        Gr1: Exercises. Warm         Gr2: control
  al, (64) 1996        up 10 min on
                       stationary bicycle.
                       Then knee extension
                       from 90[degrees] to
                       maximal extension,
                       sitting, with 1-3 kg
                       around ankle; knee
                       flexion from 90[degrees]
                       to maximal flexion,
                       standing on heel and
                       toes; knee flexion,
                       standing, with hip
                       straight; hamstring
                       muscle force; hip
                       abduction; hip
                       extension; passive
                       knee extension. Two
                       sets of 10 repetitions,
                       10-s isometric hold.
                       Stretches performed 5
                       times. Total of 3 times
                       a week, 40 min each
                       time, for 5 wk.

Deyle et al, (30)    Gr1: Manual therapy          Gr2: control.
  2000                 and knee exercises.          Subtherapeutic
                       Passive physiologic          ultrasound for
                       and accessory joint          10 min at 0.1
                       movements, muscle            W/[cm.sup.2] and
                       stretching, and soft-        10% pulsed
                       tissue mobilization,         mode
                       applied primarily to
                       the knee. Closely
                       supervised
                       standardized knee
                       exercise program:
                       AROM for the knee,
                       strengthening
                       exercises for the hip
                       and knee, muscle
                       stretching for the
                       lower limbs,
                       stationary bicycle,
                       and home program.

Evcik and            Gr1: home exercise           Gr3: control
  Sonel, (47)          program: isometric           (physical
  2002                 straight leg lifts,          therapist told
                       isometric quadriceps         patients to
                       femoris muscle               continue their
                       contraction and              normal daily
                       isotonic quadriceps          activities)
                       femoris muscle
                       contraction exercises
                       progressed by adding
                       weight from 0.5 to 5
                       kg, 10 repetitions
                     Gr2: regular walking
                       program

Fransen et           Gr1: individual exercise     Gr3: control;
  al, (65) 2001        Tx; choice, frequency,       patients were
                       and duration at the          on the waiting
                       discretion of the            list (were
                       physical therapist           offered Tx for
                     Gr2: group format              the second part
                       program; patients            of the study and
                       were under the               put in either the
                       supervision of a             individual or
                       physical therapist for       group exercise
                       1h, and the group            program)
                       program was
                       supplemented with a
                       home exercise
                       program

Garfinkel et         Gr1: supervised yoga         Gr2: control; no Tx
  al, (66) 1994        and relaxation
                       techniques and
                       patient education;
                       eight 60-min sessions,
                       1 time a week;
                       stretching and
                       strengthening
                       exercises
                       emphasizing
                       extension and
                       alignment; group
                       discussion, supportive
                       encouragement, and
                       general questions and
                       answers

Gur et al, (67)      Gr1: concentric; 12          Gr3: control;
  2002                 concentric extension         patients
                       and concentric flexion       maintained their
                       movements,                   normal physical
                       continuous mode              activities and
                       were used, and the           received no
                       patients trained             training but
                       reciprocally for the         were tested
                       knee extensors and           twice
                       flexors                      throughout the
                     Gr2: concentric-eccentric;     8-wk
                       6 concentric extension       experimental
                       and eccentric                period
                       extension movements,
                       then 6 concentric
                       flexion and eccentric
                       flexion movements

Hurley and           Gr1: exercise program        Gr2: control;
  Scott, (68)          for 5 wk, 2 times a          rehabilitation
  1998                 week for 30 min; 24          was delayed
                       isometric quadriceps
                       femoris muscle
                       voluntary contractions
                       (4 x 6 repetitions,
                       field 4 s, 2-min rest
                       between sets), 2-min
                       stationary bicycle,
                       1-min isotonic knee
                       extension (concentric
                       quadriceps femoris
                       muscle contractions)
                       and flexion feccentric
                       quadriceps temoris
                       muscle contractions)
                       to 90[degrees] of flexion
                       using therapeutic
                       resistance bands, 3
                       functional exercises
                       (sit-stand, step-ups,
                       step-downs), and 3
                       balance/coordination
                       exercises (unilateral
                       stance, balance
                       boards) that were
                       each performed for
                       1 min

Kovar et al, (69)    Gr1: Exercise. Twenty-       Gr2: control; each
  1992                 four 90-min sessions         week, the
                       of walking and               patients were
                       education designed           contacted by
                       and led by a physical        the study
                       therapist. Light             coordinator via
                       stretching and               telephone to
                       strengthening                discuss the
                       exercises; guest             nature of their
                       speakers on the              ADL
                       medical aspects of
                       OA and exercise;
                       group discussion
                       about barriers and
                       benefits of walking;
                       instruction in proper
                       walking techniques
                       and the maintenance
                       of a walking
                       program; supportive
                       encouragement and
                       up to 30 min of
                       walking.

Kreindler et         Gr2: progressive             Gr4: 10
  al, (70) 1989        exercise program             quadriceps
                       consisting of                femoris muscle
                       quadriceps femoris           setting exercises
                       and hamstring muscle         for warm-up
                       strengthening                before
                       exercises; exercises         exercising on
                       were begun in                the Cybex; the
                       session , monitored          exercise
                       3 times a week, and          positions on the
                       progressed at weekly         Cybex matched
                       intervals for 6              the evaluation
                       consecutive wk               positions; 2-min
                     Gr3: same as Gr1,              rest periods
                       combined with                were granted
                       progressive Kinetron         between test
                       program; patients            speeds
                       exercised at spBeds        Gr1: control group
                       that registered              was evaluated
                       readings of 100-150          and told to
                       psi; as patients             continue normal
                       progressed above the         activities and
                       100- to 150-psi level,       return for
                       they progressed to           reevaluation in
                       the next higher speed        6 wk

Messier et           Gr1: aerobic training        Gr3: control;
  al, (45) 1997        5-min warm-up, 40-           regularly
                       min walking phase at         scheduled
                       an intensity equal to        contacts similar
                       50%-85% of the               to those of the 2
                       subject's HR reserve,        intervention
                       and 5-min cool-down          groups; patients
                     Gr2: strengthening             were divided
                       training; warm-up, 9         into groups of
                       upper- and lower-            12-15 to
                       body exercises using         participate in
                       dumbbells and cuff           monthly on-site
                       weights (leg                 health
                       extension, leg curl,         education
                       step-up, heel-raise,         sessions during
                       chest fly, upright row,      months 1-3;
                       military press, bicep        during the
                       curls, and pelvic tilt),     transition phase
                       and cool-down                (4-6 mo),
                       phase; 2 sets of 10-         biweekly
                       12 repetitions were          telephone
                       performed for each           contact was
                       exercise                     made; the
                                                    maintenance
                                                    phase (7-18
                                                    mo) consisted of
                                                    monthly
                                                    telephone calls

Minor et al, (48)    Gr1: walking on a level      Gr3: control;
  1989                 course, progressing          gentle AROM
                       from 10 to 30 min at         and isometric
                       exercise HR                  strengthening
                     Gr2: joggrog in shallow        and relaxation
                       and deep water and           exercises, with
                       modified calisthenics        no aerobic
                       performed in chest-          stimulus period
                       high water

O'Reilly et          Gr1: Exercise program        Gr2: control; no Tx
  al, (71) 1999        consisting of the
                       following: (1)
                       isometric quadriceps
                       femoris muscle
                       contraction in full
                       extension, held for 5
                       s; (2l isotonic
                       quadriceps femora
                       muscle contraction in
                       mid flexion; (3)
                       isotonic quadriceps
                       femoris muscle
                       contraction in full
                       flexion; (4) isotonic
                       quadriceps femoris
                       muscle contraction in
                       full extension; and (5)
                       dynamic stepping
                       exercise. Exercises
                       increased to a
                       maximum of 20
                       repetitions and were
                       performed at home
                       on a daily basis.
                       Subjects were visited
                       at weeks 2 and 6
                       and at month 3.

Peloquin et          Gr1: 3 times a week,         Gr2: control; 1-h
  al, (72) 1999        1-h exercise session;        education/
                       5-min warm-up, brisk         information
                       walk, muscle                 sessions 2 times
                       strengthening with           a week
                       Thera-Band, (c)
                       resistance program
                       (isometric contractions
                       at 3 different angles),
                       5-min cool-down

Penninx et           Gr1: Strengthening           Gr3: Control.
  al, (73) 2001        training. Ten-min            During the first
                       warm-up and cool-            3 mo, monthly
                       down phase and 40-           group sessions
                       min phase consisting         on education
                       of 2 sets of 12              related to
                       repetitions of 9             arthritis
                       exercises: leg               management,
                       extension, leg curl,         including time
                       step-up, heel-raise,         for discussions
                       chest fly, upright row,      and social
                       military press bicep         gatherings.
                       curls, and pelvic tilt.      Later,
                       Home program.                participants
                     Gr2: Aerobic training.         were called
                       Ten-min warm-up and          bimonthly
                       cool-down and 40-            (months 4-6) or
                       min period of walking        monthly (months
                       at an intensity of           7-18) to
                       50%-70% of HR                maintain health
                       reserve. During              updates and
                       months 4-6, exercise         provide support.
                       leader visited 4 times
                       and called 6 times to
                       offer assistance with
                       home program.

Peterson et          Gr1: 8 wk, hospital-         Gr2: control;
  al, (74) 1993        based educational            patients were
                       and walking program.         telephoned
                       The sessions included        each week for a
                       warm-up,                     report on health
                       strengthening, and           and exercise
                       cool-down exercises.         activities
                       The course began with
                       easily mastered
                       frequency and intensity
                       of walking. At first,
                       subjects walked 3
                       times a week for 5 min
                       and always so that
                       knee pain was not
                       exacerbated. Each
                       walking session was
                       increased by 2.5 min
                       a week, if tolerated,
                       until the subject
                       walked 4 times a
                       week for 30 min each
                       session.

Petrella, (75)       Gr1: Progressive             Gr2: knee
  2000                 exercise program             unloading (joint
                       consisting of the            capsule stretch),
                       following exercises:         ROM (knee
                       (1) knee unloading           extension),
                       (joint capsule stretch)      without
                       with an ankle weight         progression
                       of 1-2 kg; (2) ROM
                       (knee extension) with
                       foot elevated, patients
                       push the knee toward
                       the floor; (3) open
                       kinetic gain
                       resistance exercises
                       (SLR with "T" motion)
                       3 times; and (4)
                       closed kinetic chain
                       resistance exercises
                       (eccentric wall slide
                       to knee flexion of
                       30[degrees], and patients
                       push off on a towel
                       wrapped under the
                       foot, with the knee
                       bent at 30[degrees]).
                       All exercises with
                       progression.

Rejeski et           Gr1: Aerobic Tx group.       Gr3: Control.
  al, (76) 1998        Participants walked at       Participants
                       an intensity of 50%-         were
                       75% of HR reserve.           consolidated in
                     Gr2: Resistance training       of 10-
                       group. Participants          15. During
                       performed 9 different        months 1-3,
                       upper- and lower-            they received a
                       body exercises: leg          monthly
                       extensions, leg curs,        education
                       step-ups, heel-raises,       session that
                       chest flies, upright         lasted 1.5 h.
                       rows, military               Patients in this
                       presses bicep curls,         condition were
                       and pelvic tilts.            contacted by
                       Participants                 telephone once
                       completed 2 sets of          every 2 wk for
                       each exercise at a           months 4-6 and
                       frequency of 10-12           then monthly for
                       repetitions.                 the remainder
                                                    of the study.

Rodgers et           Gr1: 6 wk preoperative       Gr2: concurrent
  al, (77) 1998        PT, 3 times a week;          therapy only
                       program
                       individualized
                       according to baseline
                       physical capacity.
                       Stretching and warm-
                       up, heel-slides,
                       isometric quadriceps
                       femoris muscle sets
                       (quad sets), SLR,
                       short-arc quad sets,
                       standing squats, step-
                       ups, and stationary
                       bicycle.

Rogind et            Gr1: Mobility training       Gr2: control; no Tx
  al, (78) 1998        and venous therapy
                       performed from
                       supine position,
                       moving the joints of
                       the lumbar spine,
                       hips, knees, ankles,
                       shoulders, and
                       elbows. LE and
                       truncal strengthening:
                       repetitive exercises
                       for quadriceps
                       femoris, hip adductor
                       and abductor,
                       hamstring, gluteus
                       maximus, erector
                       spinae, and
                       abdominal muscles.
                       Stretching: calf,
                       quadriceps femoris,
                       hip adductor,
                       hamstring, gluteus
                       maximus, lower back,
                       and pectoralis major
                       muscles. Balance and
                       coordination
                       exercises.

Schilke et           Gr1: Exercise. Warm-up       Gr2: control; no Tx
  al, (79) 1996        of 5 min on stationary
                       bicycle, then
                       isokinetic exercise at
                       90[degrees]/s for 24
                       sessions. Session 1, 1
                       set of 5 contractions;
                       session 2, 2 x 5
                       contractions (1-min
                       rest between sets);
                       session 3, 3 x 5
                       contractions (1-min
                       rest between sets);
                       session 4, 4 x 5
                       contractions (1-min
                       rest between first 2
                       sets, 15-min rest
                       between sets 3 and
                       4); session 5, 5 x 5
                       contractions (1-min
                       rest between first 2
                       sets and between sets
                       4 and 5, 15-min rest
                       between sets 3 and
                       4); and sessions 6-
                       24, 6 x 5
                       contractions (1-min
                       rest between first 3
                       sets and last 3 sets,
                       15-min rest between
                       sets 3 and 4).

Stamm et             Gr1: Exercise. Each          Gr2: Control. Oral
  al, (80) 2002        patient received 30          and written
                       min of oral and              information
                       written instructions for     about hand
                       oint protection and          OA, joint
                       5 min of training in         anatomy, and
                       home exercises               pathogenesis of
                       which consisted of 7         OA. Patients
                       exercises to perform         received a
                       with both hands 10           piece of
                       times a day.                 Dycem (a) to open
                                                    jars for the
                                                    study period of
                                                    3 mo.

Suomi and            Gir1: Water exercises        Gr2: Control.
  Lindauer, (81)       were performed in a          Patients were
  1997                 therapeutic pool with        asked to refrain
                       a water temperature          from engaging
                       of 85[degrees]-87[degrees]F  in any
                       depth of 1.07-1,52           organized
                       m (3.5-5.0 ft) for 45        physical activity
                       min, 3 times a week          program or
                       for 6 wk, following          beginning any
                       Arthritis Foundation         new physical
                       Aquatic Program              activity for the
                       guidelines.                  duration of the
                                                    investigation.

Topp et al, (42)     Gr1: dynamic resistance      Gr3: no
  2002                 with Thera-Band              intervention
                       elastic bands; warm-
                       up 5 min, strength
                       tramin 30 min, cool-
                       down min
                     Gr2: standard isometric
                       training techniques;
                       resistance with Thera-
                       Band elastic bands
                       that patients were
                       unable to stretch
                     Gr1 and Gr2: muscles
                       were ankle plantar
                       flexors and
                       dorsiflexors, knee
                       extensors and flexors,
                       and hip extensors
                       and flexors

van Baar et          Gr1: Exercises for           Gr2: concurrent
  al, (82) 1998        muscle functions             therapy only
                       (force and length,
                       mobility, and
                       coordination and
                       exercises for
                       elementary movement
                       abilities and
                       locomotion abilities.
                       Instructions for the
                       adaptation of ADL
                       and home exercises
                       were given.
                       Combined with
                       concurrent therapy.

van Baar et          Gr1: Exercises for           Gr2: concurrent
  al, (83) 2001        muscle functions             therapy only
                       (force and length(,
                       mobility, and
                       coordination and
                       exercises for
                       elementary movement
                       abilities and
                       locomotion abilities.
                       Instructions for the
                       adaptation of ADL
                       and home exercises
                       were given. Exercises
                       occurred 1-3 times a
                       week de ending on
                       pain level, 30 min
                       per session.

                                                Concurrent
Author/Year          Outcomes                   Therapy

Bautch et            Pain (VAS, 0-10)           N/A
  al, (63) 1997      AIMS (0-good
                       health status)

Borjessson et        Pain Buring walking        N/A
  al, (64) 1996        (11-grade
                       category scale)
                     Muscle torte (peak
                       torque [Nxm]) of
                       knee flexors and
                       extensors
                     Ability to step up
                       and down (3-
                       grade scale:
                       improved,
                       unchanged, or
                       worse)

Deyle et al, (30)    WOMAC (mm)                 N/A
  2000               Mean distance (m)
                       walked in 6 min

Evcik and            WOMAC-pain (0-             None
  Sonel, (47)        10
  2002               VAS (0-10)
                     WOMAC-physical
                     function (0-68)
                     NHP-pain
                     NHP-energy
                     NH P-Physical
                     mobility
                     NHP-sleep

Fransen et           WOMAC-pain (0-             N/A
  al, (65) 2001        100)
                     WOM C-function
                       (0-100, 100=no
                       pain)
                     Knee extensor and
                       flexor force (N)
                     Gait analysis: fast
                       speed (cm/s), fast
                       cadence (steps/
                       min and fast
                       stride length (cm)
                     SF-36-physical
                       mean-50, SF-36-
                       mental mean=50

Garfinkel et         Hand pain (VAS)            N/A
  al, (66) 1994      Tenderness of the
                       fingers
                       (dolorimeter)
                     ROM
                     Hand grip force
                     Circumference of the
                       finger joints
                     Hand function
                       (Stanford Hand
                       Assessment
                       Questionnaire)

Gur et al, (67)      Pain at night              For Gr1 and Gr2,
  2002               Pain after inactivity        a spectrum of
                     Pain sitting                 angular
                     Pain rising from a           velocities
                       chair                      var~ing from
                     Pain standing                30[degrees]/s to
                     Pain climbing stairs         180[degrees]/s at
                     Pain descending              30[degrees] inter-
                       stairs                     vals (30[degrees],
                     Pain total score (10-        60[degrees],
                       point scale,               90[degrees], etc)
                       0=no pain)                 bilaterally was
                     15-m walk (,s)               used, a 2-min
                     Time rising trom a           rest was given
                       chair (s)                  between knee
                     Time climbing stairs         extensor and
                       (s)                        flexor
                     Time descending              movements in
                       stairs (s)                 Gr2, and a
                     Total score functional       5-min rest was
                       tests (s)                  given between
                                                  the legs in both
                                                  training groups

Hurley and           Isometric quadriceps       N/A
  Scott, (68)          femoris muscle
  1998                 force (muscle
                       voluntary
                       contraction)
                     Quadriceps femoris
                       muscle voluntary
                       activation (%)
                     Knee joint ositicn
                       sense ([degrees])
                     Aggregate functional
                       performance
                       time (s)
                     Lequesne Index
                       (0-24)

Kovar et al, (69)    6-min test of walking      N/A
  1992                 distance (m)
                     AIMS subscales:
                       hysical activity
                       0-10,
                       10=greater
                       disability), arthritis
                       impact (0-10,
                       10=poorer health
                       status)
                     Arthritis pain (0-10,
                       10-greater pain),
                       medication use
                       (0-6, 6-less
                       frequent
                       medication use)

Kreindler et         Quadriceps femoris         N/A
  al, (70) 1989        muscle force
                       relative to body
                       weight at 60[degrees],
                       80[degrees], and
                       120[degrees]/s
                       measured with the
                       Cybex 3 times a
                       week for 6 wk

Messier et           Walking speed              For Gr1 and Gr2,
  al, (45) 1997        (cm/s) cadence             18-mo period;
                       (steps/min), stride        3-mo facility-
                       length (cm),               based program
                       stance time (s), %         followed by
                       swing                      15-mo home-
                                                  based
                                                  program: (1)
                                                  3-mo transitory
                                                  phase of
                                                  contacts once
                                                  every 2 wk (4
                                                  home visits and
                                                  6 telephone
                                                  calls) and (2)
                                                  12-mo
                                                  maintenance
                                                  phase of
                                                  telephone
                                                  contacts once
                                                  every 3 wk
                                                  during the first
                                                  3 mo and
                                                  monthly contact
                                                  during mo 9-
                                                  18

Minor et al, (48)    Change in AIMS-            Gr1 and Gr2:
  1989                 pain (0-10)                patients with
                     Change in AIMS-              exercise HR that
                       physical (0-10)            varied  60%-
                     Chane in morning             80% of
                       stiffness (h)              maximal HR
                     Change in grip force         were assigned
                       (mm Hg)                    individually to
                     Change in trunk              participate in
                       flexibility (cm)           aerobic
                     Change in 15.2-m             exercises (pool
                       (50-ft) walking            and walk
                       time (s)                   groups); classes
                     Change in aerobic            included a
                       capacity (mL/kg            warm-up,
                       [MIN.SUP.-1])              general
                     Change in exercise           flexibility and
                       endurance (min)            isometric
                     Change in resting            strengthening of
                       blood pressure:            postural
                       systolic and               muscles, an
                       diastolic (mm Hg)          aerobic stimulus
                     Change in exercise           period
                       HR (bpm)                   pregressing to
                                                  30 min of
                                                  continuous
                                                  activety, and a
                                                  cooldown of
                                                  10 min of
                                                  AROM and
                                                  stretching

O'Reilly et          WOMAC-pain (0--            N/A
  al, (71) 1999        20, higher
                       score=more pain)
                     WOMAC-function
                       (0-68, higher
                       score=more
                       disability)
                     Isometric quadriceps
                       femoris muscle
                       force
                     Self-reported health
                       status (SF-36, 0-
                       100, higher
                       score=better
                       health)

Peloquin et          AIMS2 10-10,               N/A
  al, (72) 1999        0=good health
                       status)
                     Aerobic capacity (m)
                     Hamstring muscle
                       and low back
                       flexibility (in)
                     Quadriceps temoris
                       muscle isometric
                       force (N*m)
                     Hamstring muscle
                       isometric force
                       (N*m)
                     Quadriceps femoris
                       and hamstring
                       muscle isokinetic
                       force (N*m)

Penninx et           Incidence of               N/A
  al, (73) 2001        disability in ADL
                     Disability in
                       transferring from a
                       bed to a chair
                     Disability in bathing
                     Disability in toileting
                     Disability in dressing
                     Disability in eating

Peterson et          Fast and free: 6-min       N/A
  al, (74) 1993        walk (m)
                     Free speed (m/min)
                     Free cadence (steps/
                       min)
                     Free stride (m)
                     Fast speed (m/min)
                     Fast cadence (steps/
                       min)
                     Fast stride (ml
                     AIMS-physical
                       activity
                     AIMS-pain
                     AIMS-medication
                       use

Petrella, (75)       Mean difference in         Oxaprozin 1,200
  2000                 pain at rest, VAS          mg orally daily
                       (0-10, 0=no pain)
                     Mean difference in
                       pain following self-
                       paced step test,
                       VAS (0-10, 0=no
                       pain)
                     Mean difference in
                       pain following self-
                       paced walk test,
                       VAS (0-10, O=no
                       pain)
                     Mean difference in
                       WOMAC=pain
                       (0-10 0=no pain)
                     Mean difference in
                       WOMAC-stiffness
                       (0-10, 0=no
                       stiffness)
                     Mean difference in
                       WOMAC-physical
                       activity (0-10,
                       O=no lack of
                       function)
                     ROM in knee flexion
                       ([degrees])
                     Mean difference in
                       self-paced step test
                       (s)
                     Mean difference in
                       self-paced step test
                       (metabolic
                       equivalent units)
                     Mean difference in
                       self-paced walk test
                     Mean difference in
                       self-paced walk test
                       (metabolic
                       equivalent units)
                     Mean difference in
                       physical activity
                       scale for elderly
                       people

Rejeski et           Stair-climbing time (s)    Gr1 and Gr2: 3-
  al, (76) 1998      Climbing self-efficacy       mo facility-
                       score                      based exercise
                       (0-completely              followed by
                       uncertain,                 15-mo home
                       10-completely              based phase. 3
                       certain)                   times a week,
                     General health status        10-min warm-
                       (0-100, 0=1 am             up, 40-min
                       as healthy as              stimulus phase,
                       anybody I know)            and 10-min
                                                  cool-down.
                                                  Home-based
                                                  phase: (1) 4
                                                  home visits and
                                                  6 telephone
                                                  contacts during
                                                  the first 3 mo
                                                  and (2)
                                                  telephone calls
                                                  every 3 wk for
                                                  the second 3
                                                  mo, then one
                                                  telephone call
                                                  each month for
                                                  the remainder
                                                  of the study.

Rodgers et           ROM ([degrees])            Same knee
  al, (77) 1998      Hospital for Special         implant; same
                       Surgery Knee               postoperative
                       Rating Scale score         therapy,
                                                  including ankle
                                                  pumps, quad
                                                  sets, SLR, short-
                                                  arc quad sets,
                                                  heel-slides,
                                                  hamstring
                                                  muscle-
                                                  stretching,
                                                  hamstring
                                                  muscle sets, hip
                                                  abduction, and
                                                  hip adduction.
                                                  Patients started
                                                  gait training on
                                                  the first
                                                  postoperative
                                                  day. They were
                                                  discharged
                                                  depending on
                                                  their progress
                                                  and were
                                                  instructed to
                                                  begin a home
                                                  PT program.

Rogind et            Pain at night (0-10,       N/A
  al, (78) 1998        0=no pain)
                     Pain at rest (0-10,
                       0=no pain)
                     Pain on wet ht
                       bearing (0-10,
                       0=nopain
                     ROM in knee flexion,
                       most affected knee
                       ([degrees])
                     ROM in knee flexion,
                       least affected knee
                       ([degrees])
                     Walking speed (m/s)
                     Stair-climbing time (s)
                     Stance, most affected
                       LE (s)
                     Stance, least affected
                       LE (s)
                     Algofunctional Index
                       (0=mild, 14 or
                       higher=extrenely
                       severe pain,
                       discomfort, or
                       stiffness during
                       ADL)
                     Posturography
                       ([cm.sup.2]), stable
                       platform--eyes open
                     Posturography
                       ([cm.sup.2]), stable
                       platform--eyes closed
                     Posturography
                       ([cm.sup.2]), moving
                       platform--eyes open
                     Posturography
                       ([cm.sup.2]), moving
                       platform--eyes closed

Schilke et           Osteoarthritis             N/A
  al, (79) 1996        Screening Index-
                       pain (10 cm,
                       0=no pain)
                     Osteoarthritis
                       Screenin Index-
                       stiffness 0 cm,
                       0=no stiffness)
                     Osteoarthritis
                       Screenin Index-
                       mobility (10 cm,
                       0=good mobility)
                     AIMS-arthritis
                       activity (0=good
                       health status
                     Peak torque, right
                       knee extensors
                       (ft x lb)
                     Peak forgue, right
                       knee flexors (ft x lb)
                     Peak torque, left
                       knee extensors
                       (ft x lb)
                     Peak forque, left
                       knee flexors (ft x lb)

Stamm et             Chan e of grip force       N/A
  al, (80) 2002      VAS (no. of patients
                       improved)

Suomi and            Peak torque (N*m)          N/A
  Lindauer, (81)       ROM([degrees])
  1997

Topp et al, (42)     WOMAC-stiffness            None
  2002               WOMAC-functional
                       limitation
                     WOMAC-pain
                     Time to et down to
                       floor (s)
                     Time to et up from
                       floor (s)
                     Time to go up stairs
                       (s)
                     Time to go down
                       stairs (s)
                     Pain while getting
                       down to floor
                     Pain while getting up
                       from floor
                     Pain while going up
                       stairs
                     Pain while going
                       down stairs

van Baar et          Improvement in pain        Tx by the general
  al, (82) 1998        at assessment,             practitioner:
                       VAS (0-100,                prescription of
                       0-no pain)                 medication
                     Change in pain in            (patients were
                       past week                  instructed to
                     Improvement in pain          use as little as
                       in past month,             possible) and
                       VAS (0-100,                patient
                       O=no pain)                 education
                     Improvement in hip           through
                       ROM                        brochure
                     Improvement in knee          topics,
                       ROM                        including
                     Improvement in hip           diagnosis,
                       muscle force               prognosis,
                     Improvement in knee          advice
                       muscle force               concerning
                     Improvement in self-         rest, daily
                       reported                   activities and
                       disability,                diet, use of
                       influence of               aids, and
                       Rheumatic Disease          medical Tx
                       on General Health
                       and Lifestyle
                     Improvement in
                       physcial activity

van Baar et          Pain, VAS (0-100,          General
  al, (83) 2001        0=no pain,                 practitioner
                       100=very severe            prescribed
                       pain)                      acetaminophen;
                     Observed disability          prescription of
                       (5-m walking time,         NSAIDs
                       stand-to-sit time,         restricted to
                       stand-to-recline           naproxen,
                       time, and levels of        diclofenac
                       caution and                notrium, and
                       rigidity during            ibuprofen.
                       performance of             Patients
                       the tasks)                 instructed to
                                                  use as few as
                                                  possible.
                                                  Brochure for
                                                  patient
                                                  education
                                                  covering
                                                  diagnosis,
                                                  prognosis,
                                                  advice about
                                                  rest, daily
                                                  activities and
                                                  diet, use of
                                                  aids, and
                                                  medical Tx.

                     Frequency
                     and               Follow-up         Quality
Author/Year          Duration          Duration          (R, B, W)

Bautch et            3 times a         N/A               1, 0, 0
  al, (63) 1997        week for
                       12 wk

Borjessson et        3 times a         N/A               1, 0, 1
  al, (64) 1996        week for
                       5 wk

Deyle et al, (30)    30 min 2          End of Tx 4       2, 1, 1
  2000                 times a           wk
                       week for        Follow-up at
                       4 wk              1 y

Evcik and            Gr1: 2            6 mo 0, 0, 1
  Sonel, (47)          times a
  2002                 day for 3
                       mo
                       Gr2: 10
                       min, 3
                       times a
                       week for
                       3 mo;
                       gradually
                       increased
                       walking
                       time up
                       to 30 min

Fransen et           8 wk              N/A               1, 0, 1
  al, (65) 2001      Gr1: at the
                       physical
                       therapist's
                       discretion
                     Gr2: 2
                       times a
                       week

Garfinkel et         1 time a          N/A               1, 0, 0
  al, (66) 1994        week for
                       10 wk

Gur et al, (67)      3 days a          N/A               1, 0, 0
  2002                 week for
                       8 wk

Hurley and           2 times a         6 mo              0, 0, 1
  Scott, (68)          week for
  1998                 5 wk

Kovar et al, (69)    3 times a         N/A               2, 0, 1
  1992                 week for
                       8 wk

Kreindler et         3 times a         6 wk              2, 0, 0
  al, (70) 1989        week for
                       6 wk

Messier et           3 times a         N/A               2, 0, 0
  al, (45) 1997        week for
                       18 mo

Minor et al, (48)    12 wk             3, 9 mo           1, 0, 1
  1989

O'Reilly et          1 time a          N/A               2, 0, 1
  al, (71) 1999        day for 6
                       mo

Peloquin et          3 times a         N/A               2, 0, 1
  al, (72) 1999        week for
                       3 mo

Penninx et           3 times a         N/A               1, 0, 1
  al, (73) 2001        week,
                       3-m
                       supervised
                       facility-
                       based
                       program
                       and 15-m
                       home-
                       based
                       program

Peterson et          8 wk              8 wk              1, 0, 1
  al, (74) 1993

Petrella, (75)       Gr1: Weeks        N/A               2, 1, 1
  2000                 1-2: 3
                       sessions/
                       wk, 2
                       reps/session
                     Weeks 3-4:
                       3
                       sessions/
                       wk; 3
                       reps/session
                     Weeks 5-6:
                       3
                       sessions/
                       wk; 3
                       reps/session
                     Weeks 7-8:
                       5
                       sessions/
                       wk; 5
                       reps/session
                     Gr2: 3 times
                       a week
                       for 8 wk

Rejeski et           3 times a         N/A               1, 0, 0
  al, (76) 1998        week for
                       the first 3
                       mo; 15-
                       mo home-
                       based
                       program

Rodgers et           3 times a         6 wk, 3 mo        0, 0, 1
  al, (77) 1998        week for
                       6 wk

Rogind et            2 times a         3, 12 mo          2, 0, 1
  al, (78) 1998        week for
                       3 mo

Schilke et           3 times a         N/A               2, 0, 0
  al, (79) 1996        week for
                       8 wk

Stamm et             3 mo              N/A               1, 0, 0
  al, (80) 2002

Suomi and            3 times a         N/A               1, 0, 0
  Lindauer, (81)       week for
  1997                 6 wk

Topp et al, (42)     3 times a         None              1, 0, 1
  2002                 week
                       (twice at
                       ome
                       and once
                       under
                       supervision)

van Baar et          Gr1: 1-3          24 wk             2, 0, 1
  al, (82) 1998        times a
                       week,
                       depending
                       on pain
                       level, for
                       12 wk
                     Gr2:
                       patients
                       consulted
                       their
                       general
                       practitioner
                       at least
                       twice, at
                       weeks 0
                       and 12,
                       and
                       when
                       needed

van Baar et          1-3 times a       24, 36 wk         2, 0, 1
  al, (83) 2001        week for
                       12 wk

(a) R=randomization: 2 points maximum (Jadad scale (15)), B-blinding:
2 points maximum (Jadad scale (15), W=withdrawals: 1 point maximum
(Jadad scale (15), ACR=American College of Rheumatology, ADL=activities
of daily living, AIMS=Arthritis Impact Measurement Scales,
AIMS2=Arthritis Impact Measurement Scales 2, AROM-active range of
motion, CCT=controlled clinical trial, Gr=group, HR=heart rate,
LE=lower extremity, N/A=not available, N/M=not mentioned,
NHP=Nottingham Health Profile, NSAID=nonsteroidal anti-inflammatory
drug, OA=osteoarthritis, PROM=passive range of motion, PT=physical
therapy, RA=rheumatoid arthritis, RCT=randomized controlled trial,
ROM=range of motion, SD=standard deviation, SF-36=Medical Outcomes
Study 36-Item Short-Form Health Survey questionnaire, SLR=straight
leg raising, TKA=total knee arthoplasty, Tx=treatment, VAS=visual
analog scale, WOMAC=Western Ontario and McMaster Universities
Osteoarthritis Index.

(b) Altman R, Alarcon G, Appelrouth D, et al. The American College
of Rheumatology criteria for the classification and reporting of
osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601-1610.

(c) The Hygenic Corp, 1245 Home Ave, Akron, OH 44310-2575.

(d) Dycem Ltd, Units 2-4, Ashley Hill Trading Estate, Bristol
BS2 9BB, United Kingdom.

Appendix 3.

Literature Search Strategy (Part of a Global
Search) (a)

The literature search strategy used was as
follows:

 1 exp osteoarthritis/
 2 osteoarthritis.tw.
 3 osteoarthrosis.tw.
 4 degenerative arthritis.tw.
 5 exp arthritis, rheumatoid/
 6 rheumatoid arthritis.tw.
 7 rheumatism.tw.
 8 arthritis, juvenile rheumatoid/
 9 caplan's syndrome.tw.
10 felty's syndrome.tw.
11 rheumatoid.tw.
12 ankylosing spondylitis.tw.
13 arthrosis.tw.
14 sjogren$.tw.
15 or/1-14
16 heat/tu
17 (heat or hot or ice).tw.
18 cryotherapy.sh,tw.
19 (vapocoolant or phonophoresis).tw.
20 exp hyperthermia, induced/
21 (hypertherm$ or thermotherapy).tw.
22 (fluidotherapy or compression).tw.
23 15 and 22
24 clinical trial.pt.
25 randomized controlled trial.pt.
26 tu.fs.
27 dt.fs.
28 random$.tw.
29 placebo$.tw.
30 ((sinq$ or doubl$ or tripl$) adj (masked
or blind$).tw.
31 sham.tw.
32 or/24-31
33 23 and 32

(a) Reprinted with permission of the American Physical
Therapy Association from: Ottawa Panel Evidence-Based
Clinical Practice Guidelines for Therapeutic
Exercises in the Management of Rheumatoid Arthritis
in Adults. Phys. Ther. 2004;84:934-972.


Appendix appendix, small, worm-shaped blind tube, about 3 in. (7.6 cm) long and 1-4 in. to 1 in. (.64–2.54 cm) thick, projecting from the cecum (part of the large intestine) on the right side of the lower abdominal cavity.  4.

Evidence-Based Clinical Practice Guidelines clinical practice guidelines Clinical policies, practice guidelines, practice parameters, practice policies Medtalk Systematically developed statements to assist practitioner and Pt decisions about appropriate health care for specific clinical circumstances. See Psychology.  (a)

Strengthening Exercises

Lower-extremity strengthening versus control, level 1 (RCT RCT Randomized Controlled Trial
RCT Regimental Combat Team (infantry regiment with their own artillery, engineers, medical and tanks)
RCT Rollercoaster Tycoon
RCT Randomized Clinical Trial
RCT Rhondda Cynon Taff
, n=345): grade A for pain getting up from floor and functional status (clinically important benefit); grade C+ for pain during walking, pain while climbing stairs, functional tasks, and quadriceps femoris muscle
"Quads" redirects here. For other uses see Quad
The quadriceps femoris (quadriceps, quadriceps extensor, guads or quads) includes the four prevailing muscles on the front of the thigh.
 peak torque (clinical benefit); grade C for stiffness stiffness

half way to rigidity, tetany; result of insufficient use of the part.
, mobility, quadriceps femoris muscle force, muscle activation activation /ac·ti·va·tion/ (ak?ti-va´shun)
1. the act or process of rendering active.

2. the transformation of a proenzyme into an active enzyme by the action of a kinase or another enzyme.

3.
, and quality of fife (no benefit). Patients with a diagnosis of OA of the knee.

Lower-extremity isometric isometric /iso·met·ric/ (-met´rik) maintaining, or pertaining to, the same measure of length; of equal dimensions.

i·so·met·ric
adj.
1.
 strengthening versus control, level 1 (RCT, n=102): grade A for pain getting down to and up from floor (clinically important benefit); grade C+ for pain getting down and up stairs See Upstairs in the Vocabulary.

See also: Stair
 and timed functional tasks (clinical benefit); grade C for stiffness and functional status (no benefit). Patients with a diagnosis of OA of the knee.

Isotonic isotonic /iso·ton·ic/ (-ton´ik)
1. denoting a solution in which body cells can be bathed without net flow of water across the semipermeable cell membrane.

2.
 resistance training versus isotonic combined with isokinetic isokinetic /iso·ki·net·ic/ (-ki-net´ik) maintaining constant torque or tension as muscles shorten or lengthen; see isokinetic exercise, under exercise.  (Kinetron *) resistance training for knee, level 1 (RCT, n=32): grade C for quadriceps femoris muscle peak torque (no benefit). Patients with a primary diagnosis of OA of the knee.

Isotonic combined with isokinetic (Kinetron) resistance training for knee versus control, level 1 (RCT, n=32): grade C for muscle force (no benefit). Patients with primary diagnosis of OA of the knee.

Eccentric eccentric, in mechanics, device for changing rotary to back-and-forth motion. A disk is mounted off center on a shaft. One flat, open, circular end of a rod fits around the edge of the disk; the other end is usually attached to a block that slides in a slot.  resistance training (Cybex *) for knee versus control, level 1 (RCT, n=32): grade C for muscle force (no benefit). Patients with primary diagnosis of OA of the knee.

Concentric Coming from the center, or circles within circles. For example, tracks on a hard disk are concentric. Tracks on optical media are concentric or spiral shaped (in a coil) depending on the type.  resistance training for knee versus control, level 1 (RCT, n=23): grade A for pain at rest and during activities (clinically important benefit); grade C for global functional status (no benefit). Patients with knee OA bilaterally bi·lat·er·al  
adj.
1. Having or formed of two sides; two-sided.

2. Affecting or undertaken by two sides equally; binding on both parties: a bilateral agreement; bilateral negotiations.
 and grade II or III OA.

Concentric-eccentric resistance training for knee versus control, level 1 (RCT, n=23): grade A for pain at rest and during specific functional activities: 15-m walk and stair stair  
n.
1. A series or flight of steps; a staircase. Often used in the plural.

2. One of a flight of steps.



[Middle English, from Old English
 climbing/descending time (clinically important benefit). Patients with knee OA bilaterally and grade II or III OA.

Home program strengthening for knee versus control, level 1 (CCT CCT Circuit
CCT Commission Canadienne du Tourisme (Canadian Tourism Commission)
CCT Correlated Color Temperature
CCT Common Customs Tariff (EU)
CCT Certificate of Completion of Training
, n=81): grade A for pain, functional status, energy level, and ROM in flexion flexion /flex·ion/ (flek´shun) the act of bending or the condition of being bent.

flex·ion
n.
1. The act of bending a joint or limb in the body by the action of flexors.

2.
 (clinically important benefit); grade C for physical mobility, muscle force, swelling swelling /swell·ing/ (swel´ing)
1. transient abnormal enlargement of a body part or area not due to cell proliferation.

2. an eminence, or elevation.
, and exercise (no benefit). Patients with OA of the knee.

General LE exercise program (including muscle force, flexibility, and mobility/coordination) versus control, level 1 (RCT, n=490): grade A for pain at night and ability on stairs (clinically important benefit); grade C for knee flexion ROM, muscle force, knee joint position, gait, functional status, quality of life, muscle activation, stiffness, and physical activity (no benefit). Patients with a diagnosis of OA.

Progression progression, in mathematics, sequence of quantities, called terms, in which the relationship between consecutive terms is the same. An arithmetic progression is a sequence in which each term is derived from the preceding one by adding a given number, d,  versus no-progression LE strengthening exercises, level 1 (RCT, n=179): grade A for pain at rest and ROM (clinically important benefit); grade C for stiffness and functional status (no benefit). Patients with radiographic radiographic (rā´dēōgraf´ik),
adj relating to the process of radiography, the finished product, or its use.
 evidence of OA in the tibiofemoral tibiofemoral /tib·io·fem·or·al/ (tib?e-o-fem´o-ral) pertaining to the tibia and femur.

tibiofemoral

pertaining to the tibia and femur.
 compartment compartment

a part of the body as a whole and divided from the rest by a physical partition.


fluid compartment
that liquid part of the body excluded by cell membranes. Includes intravascular and intercellular compartments.
.

Hand strengthening versus control, level 1 (RCT, n=40): grade A for pain and grip force (clinically important benefit). Patients who met the American College American College is the name of:
  • American College Dublin, Dublin, Ireland
  • The American College in Madurai, Tamil Nadu, India
  • The American College of the Immaculate Conception, Leuven (also known as Louvain), Belgium
 of Rheumatology rheumatology /rheu·ma·tol·o·gy/ (-tol´ah-je) the branch of medicine dealing with rheumatic disorders, their causes, pathology, diagnosis, treatment, etc.

rheu·ma·tol·o·gy
n.
 criteria criteria (krītēr´ē),
n.
 for hand OA. (154)

General Physical Activity, Including Fitness and Aerobic Exercises aerobic exercise,
n sustained repetitive physical activity, such as walking, dancing, cycling, and swimming, that elevates the heart rate and increases oxygen consumption resulting in improved functioning of cardio-vascular and respiratory systems.


Whole-body functional exercise versus control, level 1 (RCT, n=864): grade A for pain and functional status (mobility, walking, work, disability in ADL) (clinically important benefit); grade C for knee flexor flexor /flex·or/ (flek´ser)
1. causing flexion.

2. a muscle that flexes a joint.


flexor retina´culum  see entries under retinaculum.
 ROM, quadriceps femoris muscle force, hamstring muscle hamstring muscle
n.
Any of the three muscles constituting the back of the upper leg that serve to flex the knee joint, adduct the leg, and extend the thigh.
 force, gait, and quality of life (no benefit). Patients with OA of the knee.

Walking program versus control, level 1 (RCT, n=1,089): grade A for pain, functional status, stride length stride length Biomechanics The distance between 2 successive placements of the same foot, consisting of 2 step lengths; SL measured between successive positions of the left foot is always the same as that measured by the right foot, unless the subject is walking in a curve , disability transferring from bed, disability bathing, aerobic aerobic /aer·o·bic/ (ar-o´bik)
1. having molecular oxygen present.

2. growing, living, or occurring in the presence of molecular oxygen.

3. requiring oxygen for respiration.

4.
 capacity, energy level, and medication medication /med·i·ca·tion/ (med?i-ka´shun)
1. medicine (1).

2. impregnation with a medicine.

3. administration of a medicine or other remedy.
 use (clinically important benefit); grade C+ for disability in ADL (clinical benefit); grade C for walking speed, disability toileting, disability dressing, blood pressure, morning stiffness, and quality of life (no benefit). Patients with OA.

Jogging jogging

Aerobic exercise involving running at an easy pace. Jogging (1967) by Bill Bowerman and W.E. Harris boosted jogging's popularity for fitness, weight loss, and stress relief.
 in water versus control, level 1 (RCT, n=115): grade A for physical activity and aerobic capacity (clinically important benefit); grade C for morning stiffness, pain, grip force, trunk A communications channel between two points. It generally refers to a high-bandwidth, fiber-optic line between telephone switching centers (central offices). Telephone "trunks" handle thousands of simultaneous voice and data signals, whereas telephone "lines" are the wires from the  ROM, functional status, and exercise endurance Endurance
See also Longevity.

Atalanta

feminine name denotes power of endurance. [Gk. Myth.: Jobes, 148]

Boston marathon

famous 26-mile race held annually for long-distance runners. [Am. Pop. Culture: Misc.
 (no benefit). Patients with current symptoms of chronic pain and stiffness in involved weight-bearing weight-bearing adjective Referring to the ability of a part of the body to resist or support weight.  joints.

Water exercises versus control, level 1 (RCT, n=30): grade C for torque and ROM (no benefit). Patients with OA or RA diagnosed by a rheumatologist rheumatologist /rheu·ma·tol·o·gist/ (roo?mah-tol´ah-jist) a specialist in rheumatology.

rheu·ma·tol·o·gist
n.
A specialist in the diagnosis and treatment of rheumatic disorders.
 or an orthopedic orthopedic /or·tho·pe·dic/ (-pe´dik) pertaining to the correction of deformities of the musculoskeletal system; pertaining to orthopedics.  physician.

Yoga yoga (yō`gə) [Skt.,=union], general term for spiritual disciplines in Hinduism, Buddhism, and throughout S Asia that are directed toward attaining higher consciousness and liberation from ignorance, suffering, and rebirth.  versus control, level 1 (RCT, n=30): grade A for pain during activity and ROM (clinically important benefit); grade C for tenderness, muscle force, swelling, and hand function (no benefit). Patients with OA of the distal distal /dis·tal/ (-t'l) remote; farther from any point of reference.

dis·tal
adj.
1. Anatomically located far from a point of reference, such as an origin or a point of attachment.
 interphalangeal interphalangeal

situated between two contiguous phalanges.
 or proximal proximal /prox·i·mal/ (-mil) nearest to a point of reference, as to a center or median line or to the point of attachment or origin.

prox·i·mal
adj.
 interphalangeal joints in·ter·pha·lan·ge·al joint
n.
See digital joint.
 of the fingers.

Combination of Exercises

Manual therapy combined with exercise versus control, level 1 (RCT, n=83): grade A for pain (clinically important benefit); grade C for functional status (no benefit). Patients with a diagnosis of OA.

(a) RCT=randomized controlled trial A randomized controlled trial (RCT) is a scientific procedure most commonly used in testing medicines or medical procedures. RCTs are considered the most reliable form of scientific evidence because it eliminates all forms of spurious causality. , OA=osteoarthritis osteoarthritis
 or osteoarthrosis or degenerative joint disease

Most common joint disorder, afflicting over 80% of those who reach age 70. It does not involve excessive inflammation and may have no symptoms, especially at first.
, CCT=controlled clinical trial controlled clinical trial,
n a research strategy that calls for two samples: an experimental sample of patients receiving a pharmaceutical, and a second sample of control patients receiving a placebo.
, ROM=range of motion, ADL=activities of daily living, RA=rheumatoid arthritis rheumatoid arthritis

Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course.
, LE=lower extremity lower extremity
n.
The hip, thigh, leg, ankle, or foot. Also called inferior limb, pelvic limb.
.

* Cybex International Inc, 10 Trotter trotter: see Standardbred horse.  Dr, Medway
This article is about the Medway towns in England. For others, see Medway (disambiguation)


Medway is the name given to a conurbation and unitary authority in north Kent, England.
, MA 02053.
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