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Ortek Hires WR Hambrecht + Co as Exclusive Financial Advisor; Ortek to Pursue Two New Drug Applications for Its Cavistat(R) Fluoride-Free Cavity Fighting Complex.


ROSLYN HEIGHTS, N.Y. -- New Cavity Fighting BasicMints(TM) and DenClude(R) Desensitizing de·sen·si·tize  
tr.v. de·sen·si·tized, de·sen·si·tiz·ing, de·sen·si·tiz·es
1. To render insensitive or less sensitive.

2. Immunology To make (an individual) nonreactive or insensitive to an antigen.
 Toothpaste Could Offer Consumers a More Effective and Safer Alternative to Fluoride

Ortek Therapeutics, Inc announced today that it has hired WR Hambrecht + Co WR Hambrecht + Co. is a full service investment bank with headquarters in New York and San Francisco. It specializes in using its unique auction process called OpenIPO to compete with the traditional methods of larger and more established banks.  as its exclusive financial advisor and has begun its formal pursuit of two New Drug Applications for BasicMints(TM) and DenClude(R) Desensitizing Dental Cream. Both products contain CaviStat(R), Ortek's breakthrough fluoride-free cavity fighting complex. CaviStat could offer consumers a superior and safer new treatment option for one of the worlds' most prevalent diseases, tooth decay Tooth Decay Definition

Tooth decay, which is also called dental cavities or dental caries, is the destruction of the outer surface (enamel) of a tooth.
.

CaviStat, which was developed, patented and clinically tested in the Department of Oral Biology oral biology
n.
The study of the biological phenomena associated with the mouth in health and in disease.
 and Pathology at Stony Brook University The State University of New York at Stony Brook (SUNYSB), also known as Stony Brook University (SBU) is a public research university located in Stony Brook, New York (on the north side of Long Island, about 55 miles east of Manhattan, New York). , mimics saliva's profound anti-cavity properties. This natural complex is designed to simultaneously neutralize the harmful acids that erode the teeth, while strengthening and repairing the tooth structure. Fluoride only helps to remineralize remineralize,
v the replacement of depleted mineral content of bones and teeth. It is a naturally occurring process by the minerals contained in saliva. It may be promoted by certain dental treatments in the dental office and by the patient at home.
 the teeth but can also cause toxic side effects Side effects

Effects of a proposed project on other parts of the firm.
, such as dental fluorosis in children and a likely increase in bone fractures in people who are exposed to elevated levels over a lifetime.

CaviStat has been proven significantly more effective than fluoride in a two-year, 726 patient, toothpaste study that was recently published in the November 2005 issue of The Journal of Clinical Dentistry. CaviStat contains arginine arginine (är`jənĭn), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of proteins. , a common amino acid amino acid (əmē`nō), any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur. These compounds are the building blocks of proteins. , and is the key component in saliva responsible for stimulating the production of acid- neutralizing alkali by certain plaque bacteria. CaviStat also contains calcium carbonate and bicarbonate which are coordinated to strengthen and repair the tooth structure.

BasicMints with CaviStat could be the first approved cavity- fighting confection con·fec·tion
n.
A sweetened medicinal compound. Also called electuary.
 available to consumers worldwide. A soft chewable mint, BasicMints could offer cavity fighting protection to the biting surfaces of the teeth. These surfaces contain pits and fissures, which are the areas of children's teeth most prone to decay.

Ortek's DenClude(R) Desensitizing Dental Cream is an Rx toothpaste indicated for the management of tooth sensitivity. DenClude, which is only available through dental offices, contains the identical CaviStat(R) formulation tested in the above referenced study. It is Ortek's goal to have DenClude approved as the first fluoride-free cavity fighting toothpaste in the $5 billion global toothpaste market.

"Clearly our CaviStat technology has enormous health and financial implications in the oral care market. It is a disruptive technology that targets a major unmet medical need," said Mitchell Goldberg, Ortek's President. "We look forward to working with WR Hambrecht + Co as our exclusive financial advisors. They have a wealth of experience in corporate finance, business development and mergers and acquisitions."

Ortek Therapeutics Inc is a fully integrated company that develops and commercializes proprietary products for the treatment, prevention and early diagnosis of dental disorders. Ortek currently markets two proprietary Rx products for the management of sensitive teeth, Proclude(R) a professionally applied prophy paste, and DenClude Desensitizing Dental Cream, a toothpaste for home use. All technology is exclusively licensed by Ortek from the Research Foundation of the State University of New York (body) State University of New York - (SUNY) The public university system of New York State, USA, with campuses throughout the state.  at Stony Brook University.

WR Hambrecht + Co provides underwriting and advisory services for healthcare, technology and emerging growth companies, as well as equity research, sales and trading, full-service and online brokerage and private equity offerings for institutions and individuals. WR Hambrecht + Co is headquartered in San Francisco with offices in Boston, Chicago, London, Montreal, New York, Philadelphia and Stamford, CT.

DenClude(R), Proclude(R) , SensiStat(R) and CaviStat(R) are registered trademarks of Ortek Therapeutics, Inc.
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Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Jul 11, 2006
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