Ono Licenses Cancer Anorexia/Cachexia Drug from Sapphire Therapeutics for Japan, Korea and Taiwan.Tokyo, Japan, Oct 26, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - Ono Pharmaceutical announced October 26 that it signed a licensing agreement with US-based Sapphire Therapeutics for a novel drug candidate, RC-1291, for the treatment of cancer anorexia/cachexia. Ono has obtained the exclusive rights to develop and commercialize RC-1291 in Japan, Korea and Taiwan under this agreement, and in consideration of such rights Ono will pay to Sapphire upfront and milestone payments as well as royalties on sales of RC-1291. RC-1291, designated as a fast-track drug candidate by the FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. for cancer anorexia/cachexia, is an orally active synthetic small molecule ghrelin mimetic mimetic /mi·met·ic/ (mi-met´ik) pertaining to or exhibiting imitation or simulation, as of one disease for another. mi·met·ic adj. 1. Of or exhibiting mimicry. 2. . A Phase II study is currently being conducted by Sapphire with cancer anorexia/cachexia patients in the USA. In addition, Ono plans to start Phase I study in Japan in the second quarter of 2007. Ghrelin is a circulating peptide hormone Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. Like other proteins, peptide hormones are synthesized from amino acids according to an mRNA template, which is itself synthesized from a DNA principally produced in stomach cells that has multiple physiological actions, including appetite stimulation and muscle-building (anabolic anabolic pertaining to or arising from anabolism. anabolic steroid steroids with a tissue-building effect. Testosterone is an example of a natural anabolic steroid with the, sometimes undesirable, effect of causing masculinization. ) effects. RC-1291 is a synthetic small molecule with similar physiological actions, like appetite stimulation and muscle-building effects, to those of ghrelin. Unlike ghrelin though, RC-1291 can be administered as an oral treatment. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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