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One! Two pharmaceutical giants team up to find a simpler, better way to fight HIV.

Treating HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.  disease could become a lot easier for many people who are on a medication regimen. Two of the world's pharmaceutical giants--Bristol-Myers Squibb and Gilead Sciences--have teamed up to create the so-called holy grail of treatment: a single pill containing an entire day's worth of antiretroviral medications.

If approved by the U.S. Food and Drug Administration, the proposed once-a-day pill containing Sustiva, Viread, and Emtriva would be the simplest anti-HIV regimen available.

AIDS treatment advocates have longed for easier-to-take courses of anti-HIV drugs since the early days of combination therapy--when 25 to 30 pills a day could be typical. Even today's simplest regimens require two to four pills daily, which some experts say still makes it burdensome to achieve near-perfect adherence. And recent studies have shown that these medications can lose their effectiveness if taken less than 95% of the time.

"I personally see a lot of patients with new infections and treatment-naive patients, and people want to start with the easiest possible dosing regimen," says Tony Mills, MD, an HIV specialist in Los Angeles who is gay and HIV-positive himself. "The easier the dosing regimen, the more likely you are to be adherent adherent /ad·her·ent/ (-ent) sticking or holding fast, or having such qualities. . The better you adhere, the more likely it is that your viral load viral load
n.
The concentration of a virus, such as HIV, in the blood.


viral load,
n a measure of the number of virus particles present in the bloodstream, expressed as copies per milliliter.
 will remain undetectable in the long term."

BMS BMS
abbr.
Bachelor of Marine Science
 spokesman Eric Miller calls the first-of-its-kind collaboration between pharmaceutical rivals an "important milestone" in HIV treatment. "It grew entirely from the companies responding to meet the growing need for increased treatment options," he says.

Because each of the component drugs in the new pill have already been approved individually by the FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
, the new combination treatment could zip through the government approval process, according to the manufacturers, and hit the market as soon as the second half of 2006.

MILESTONES

1984 Researchers discover HIV; it is three years since the first U.S. AIDS cases were reported

1987 AZT AZT or zidovudine (zīdō`vydēn'), drug used to treat patients infected with the human immunodeficiency virus (HIV), which causes AIDS; also called  is the first medication approved to treatment HIV

1995 invirase is the first protease inhibitor protease inhibitor (prō`tē-ās'), any of a class of drugs that interfere with replication of the AIDS virus (HIV), by blocking an enzyme (protease) necessary in the late stages of its reproduction.  approved for treatment; the era of combination therapy begins

1996 Viramune, the first drug in the third class of antiretrovirals, is approved

1997 Combivir, the first pill to combine two anti-HIV medications, is approved

2000 New medication Trizivir combines three nucleoside analogs into one pill

2002 The first one-pill-a-day formulation of one antiretroviral, Sustiva, is approved

2003 Fuzeon is the first approved medication in the fusion inhibitor fusion inhibitor
n.
A drug that interferes with the entry of HIV into helper T cells by inhibiting the fusion of the viral and cell membranes.
 class
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Title Annotation:medicine
Author:Adams, Bob
Publication:The Advocate (The national gay & lesbian newsmagazine)
Geographic Code:1USA
Date:Jun 21, 2005
Words:399
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