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ORTHO DERMATOLOGICAL Study Shows Benefits of RETIN-A MICRO Over RETIN-A 0.025% Cream in Reducing Facial Shine.

Health Editors

SKILLMAN, N.J.--(BW HealthWire)--Aug. 23, 2000

RETIN-A(R) MICRO(TM) (tretinoin tretinoin /tret·i·noin/ (tret´i-noin?) the all-trans stereoisomer of retinoic acid, used as a topical keratolytic in the treatment of acne vulgaris and disorders of keratinization and administered orally in the treatment of acute  gel) microsphere Not to be confused with Glass microphere.
This article largely refers to micropheres or protein protocells as small spherical units postulated by some scientists as a key stage in the origin of life.
, 0.1%, a prescription medication for the treatment of acne, may have an added benefit over RETIN-A(R) (tretinoin) 0.025% Cream in patients with oily skin. Findings from a study, published in the August issue of the dermatology dermatology (dûrmətŏl`əjē), branch of medicine concerned with diagnosis and treatment of diseases and disorders of the skin.  journal CUTIS cutis /cu·tis/ (ku´tis) the skin.

cutis anseri´na  transitory elevation of the hair follicles due to contraction of the arrectores pilorum muscles; a reflection of sympathetic nerve discharge.
, demonstrate that RETIN-A MICRO significantly reduces the appearance of facial shine compared to RETIN-A 0.025% Cream. Contributing factors to facial shine may be due to oil, sweat and dirt.

Thirty-five males and females between the ages of 12 and 24 with oily skin and facial acne participated in a randomized ran·dom·ize  
tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es
To make random in arrangement, especially in order to control the variables in an experiment.
, double-blind half-face study conducted by a contract research laboratory on behalf of Ortho Dermatological. Study participants' skin was evaluated by the study investigator and by the subjects at baseline and at three and six hours after application of the two test products. Digital photographs, which provide an objective method of evaluating facial shine, were taken at each time interval.

Statistically significant reductions were reported by the investigator in the appearance of facial shine (oiliness) at three and six hours after application of RETIN-A MICRO as compared to baseline. Study participants also reported a statistically significant decrease in facial shine on the RETIN-A MICRO side at the three- and six-hour interval.

Sides of the face treated with RETIN-A 0.025% Cream did not show statistically significant reductions compared to baseline. Photographic analyses showed reductions in facial shine for both treatments, but decreases were greater on the RETIN-A MICRO treated sides.

RETIN-A MICRO contains tretinoin, the same active ingredient An active ingredient, also active pharmaceutical ingredient (or API), is the substance in a drug that is pharmaceutically active. Some medications may contain more than one active ingredient.  in RETIN-A and RENOVA(R) (tretinoin cream) 0.05%. Designed to minimize the irritation commonly experienced with the highest strength of RETIN-A, RETIN-A MICRO entraps tretinoin in Microsponge(R) systems (round microscopic particles made of synthetic polymer Synthetic polymers are often referred to as "plastics", such as the well-known polyethylene and nylon. However, most of them can be classified in at least three main categories: thermoplastics, thermosets and elastomers. ) and formulates them into a gel. The microspheres hold the medication in reserve, allowing the skin to absorb small amounts of tretinoin over time. Dermatologists who conducted the pivotal clinical studies believe this may be why most RETIN-A MICRO patients experience little or no irritation.

Patients may see therapeutic results in two to seven weeks of treatment with RETIN-A MICRO.

An additional benefit of RETIN-A MICRO is that it can be applied immediately after patients wash their face, unlike RETIN-A, which requires a 20-30 minute waiting period.

In clinical studies, the RETIN-A MICRO irritation profile was found to be similar to a mild, local irritant ir·ri·tant
Causing irritation, especially physical irritation.

A source of irritation.

n 1. an agent that causes an irritation or stimulation.
. The most common adverse reactions adverse reactions, unfavorable reactions resulting from administration of a local anesthetic; responsible factors include the drug used, concentration, and route of administration.
 to RETIN-A MICRO were limited to mild or moderate irritation of the skin. Severe cutaneous cutaneous /cu·ta·ne·ous/ (ku-ta´ne-us) pertaining to the skin.

Of, relating to, or affecting the skin.

Pertaining to the skin.
 irritation occurred infrequently. Six percent of patients discontinued due to irritation.

During the first few weeks of therapy with RETIN-A, some irritation, including redness and peeling, will be experienced by most patients. Generally, these effects are manageable and diminish over time. However, some people with sensitive skin may experience excessive irritation.

RETIN-A(R) MICRO(TM) and RETIN-A(R) are marketed by Ortho Dermatological. MICROSPONGE(R) is a registered trademark of Advanced Polymer Systems, Inc.

For further information about RETIN-A MICRO, visit and

Note: See enclosed package inserts for full U.S. prescribing information on RETIN-A(R)MICRO(TM) and RETIN-A(R).
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Date:Aug 23, 2000
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