OPHTHALMIC DRUG SALES TO GROW 9%, TOP $4 BILLION BY 1999, WITH STRENGTHENED DEMAND IN NEW REGIONS.MOUNTAIN VIEW, Calif.--(BUSINESS WIRE)--World ophthalmic pharmaceutical markets will grow from $2.5 billion in 1993 to $4.1 billion in 1999 at a 9 percent compound annual rate, projects a new study just released by Frost & Sullivan. Anti-glaucoma drugs' share of these markets will dip from 38 percent in 1993 to 35 percent by 1999 while antibiotics rise in share from 23 to 25 percent in the same period, forecasts the report, WORLD OPHTHALMIC PHARMACEUTICAL MARKETS: TECHNOLOGY- DRIVEN PRODUCTS FOR SHIFTING GLOBAL ECONOMIES. Other major product categories include anti-allergic drugs, with 11 percent of 1993 market revenues, anti-inflammatories with 8 percent, and artificial tears artificial tears A solution containing 0.5% carboxymethyl cellulose or 5% polyvinyl alcohol, used to treat dry eye–xerophthalmia, often associated with Sjögren syndrome, which may also be due to sarcoidosis, senile lacrimal gland atrophy, acute or , anti-cataract and anti-viral drugs, each with 6 percent of world ophthalmic drug sales, including both prescription and over-the-counter products. The share of worldwide ophthalmic drug revenues accounted for by the U.S. will decline from 37 percent in 1992 to 32 percent by 1999. Although most segments face maturity in the developed world, expanding markets in regions such as South America South America, fourth largest continent (1991 est. pop. 299,150,000), c.6,880,000 sq mi (17,819,000 sq km), the southern of the two continents of the Western Hemisphere. , the Middle East and parts of the Pacific Rim Pacific Rim, term used to describe the nations bordering the Pacific Ocean and the island countries situated in it. In the post–World War II era, the Pacific Rim has become an increasingly important and interconnected economic region. will offer new growth opportunities. Manufacturers are responding to regionalized growth potentials with new subsidiaries in non-traditional growth areas. Third World markets will be particularly attracted to lower-cost generic pharmaceuticals. As the world's population ages, opportunities for existing glaucoma-related drugs, as well as anti-cataract and anti- inflammatory drugs and artificial tears, likewise expand. New classes of therapies under development, such as those for retinal diseases, will offer significant market opportunities. The development of new compounds to treat or prevent diabetic retinopathy diabetic retinopathy n. Retinal changes occurring in long-term diabetes and characterized by punctate hemorrhages, microaneurysms, and sharply defined waxy exudates. , a retinal disease, is expected. New cataract products will seek not only to improve treatment and retardation of cataracts but to actually prevent their formation. Other major technological trends include development of combination products, new surgical aids and wound healing wound healing Physiology The repair of a wound Steps Inflammation, repair and closure, remodeling, final healing; repair of incisions may be either simple–'clean' wounds with little loss of tissue heal by 'primary intention', or 'dirty' wounds heal by preparations; improved treatments of ocular disorders and glaucoma glaucoma (glôkō`mə), ocular disorder characterized by pressure within the eyeball caused by an excessive amount of aqueous humor (the fluid substance filling the eyeball). and improved delivery systems. Combination products are currently most prominently under development in the glaucoma market. New drug delivery systems include chemical blood/brain barrier products, sustained and extended release products, and molecusol delivery system products. Because advances are taking place in ocular surgery, new ophthalmic surgical aids are being developed to better control post- surgical intraocular pressure intraocular pressure n. The pressure of the intraocular fluid within the eye. intraocular pressure (in´tr , heal surgical wounds, reduce post- surgical inflammation and cystoid cystoid /cys·toid/ (sis´toid) 1. resembling a cyst. 2. a cystlike, circumscribed collection of softened material, having no enclosing capsule. cys·toid adj. mascular edema edema (ĭdē`mə), abnormal accumulation of fluid in the body tissues or in the body cavities causing swelling or distention of the affected parts. , and inhibit intra- operative miosis miosis /mi·o·sis/ (mi-o´sis) contraction of the pupil. mi·o·sis or my·o·sis n. pl. mi·o··ses 1. , among other applications. Wound healing preparations are in development for eye injuries, corneal ulcers Corneal Ulcers Definition The cornea, the clear front part of the eye through which light passes, is subject to many infections and to injury from exposure and from foreign objects. and epithelial defects. Collaborative efforts between small biotechnology firms and major manufacturers are becoming more common. Other collaborations will be used strategically to support worldwide marketing strength as companies form alliances with vendors in distant regions to capitalize on the growth of new regional markets. Frost & Sullivan is an international high-technology research firm. All Frost & Sullivan reports are based on extensive interviews with marketing and technical experts from selected companies in each market segment. Primary research is validated by thorough analysis of available secondary research. Frost & Sullivan is the leading publisher worldwide of high-technology research reports. Code: 418-52 Publication Date:1994 Price: $2395 Total Ophthalmic Pharmaceutical Product Market: Revenue Forecasts (U.S.), 1989-19993-1 Total Ophthalmic Pharmaceutical Product Market: Revenue Forecasts (U.S.), 1989-1999gures Revenue RevenuesGrowth Rate Year ($ Billion) (%) 1989 1.82 --- 1990 1.95 7.2 1991 2.10 7.8 1992 2.27 8.3 1993 2.46 8.6 1994 2.68 8.8 1995 2.92 9.0 1996 3.19 9.0 1997 3.47 9.0 1998 3.78 8.9 1999 4.12 8.8 Compound Annual Growth Rate (1992-1999): 8.9% Note: All figures are rounded. Source: Frost & Sullivan, Inc. CONTACT: For further information contact: Amy Arnell Kristina Menzefricke Nadge Keryhuel Mountain View London Paris (415) 961-9000 44 71 730 3438 33 1 4742 9127 (415) 961-5042(fax) 44 71 730 3343 33 1 4742 9129 REPEATS: New York New York, state, United States New York, Middle Atlantic state of the United States. 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