OPH3 Free electron laser-treated tisseel aids closure of trabeculectomy leaks. (Ophthalmology).OPH OPH Office of Public Health OPH Old Parliament House (Canberra, ACT, Australia museum) OPH Organophosphorus Hydrolase OPH Original Pancake House (restaurant chain) 3 FREE ELECTRON LASER-TREATED TISSEEL AIDS CLOSURE OF TRABECULECTOMY LEAKS. C. Shieh, K. Topadze, J. Shea, V. Casagrande, R. Robinson, and K. Joos. Vanderbilt University School of Medicine, Nashville, Tenn. The free electron laser A free electron laser, or FEL, is a laser that shares the same optical properties as conventional lasers such as emitting a beam consisting of coherent electromagnetic radiation which can reach high power, but which uses some very different operating principles to form the beam. (EEL) at amide band II wavelength (7.7 [micro]m) has been shown to be more effective at cutaneous contraction than the [CO.sub.2] laser independent of collagen denaturation denaturation, term used to describe the loss of native, higher-order structure of protein molecules in solution. Most globular proteins exhibit complicated three-dimensional folding described as secondary, tertiary, and quarternary structures. . Therefore, this wavelength may be effective in closing trabeculectomy. Trabeculectomies with mitomycin C were done on 14 rabbits. A leaking hole was punctured in the bleb bleb (bleb) a large flaccid vesicle, usually at least 1 cm. in diameter. bleb n. A large flaccid vesicle. bleb a large flaccid vesicle, usually at least 0. and closed randomly with one of 7 techniques: suture, glue, Tisseel, Tisseel and glue, FEL FEL - Function Equation Language. Programs are sets of definitions. Sequences are lists stored in consecutive memory. "FEL Programmer's Guide", R. M. Keller, AMPS TR 7, U Utah, March 1982. , 7.7 mm, Tisseel and FEL, 7.7 [micro]m, or Tisseel and EEL, 7.5 [micro]m (control flanking wavelength). The FEL was delivered through a hollow waveguide at 2 mL. The healing characteristics were followed for 1 month. Acute trabeculectomies, bleb holes, and closures were done on the contralateral eyes immediately before anesthesia. All trabeculectomies were examined histologically with serial sections. At 1 week, all suture treatments and tisseel combined with FEL, 7.7 [macro]m treatments, as well as one glue alone treatment showed complete healing. One anima anima /an·i·ma/ (an´i-mah) [L.] 1. the soul. 2. in jungian terminology, the unconscious, or inner being, of the individual, as opposed to the personality presented to the world (persona); by extension, used to l in each of the glue alone and tisseel and glue groups had Seidel-positive leaking blebs. The other trabeculectomies had non-leaking holes with incomplete healing of the conjunctiva. Glue was applied to the holes, and all holes were covered with conjunctiva by 1 month. In a rabbit model of trabeculectomy bleb holes, faster healing occurred with suture or application of Tisseel combined with FEL treatment at 7.7 [macro]m. Tisseel treated with low FEL energy at 7.7 [macro]m appears useful in sealing leaking trabeculectomies. |
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