ONCOLYTICS ENROLLED FOR PHASE I SYSTEMIC DELIVERY OF REOLYSIN.Oncolytics Biotech Inc. (TSX:ONC, NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on :ONCY), Calgary, it has completed patient enrolment in its Phase I U.S. clinical trial investigating the systemic delivery of REOLYSIN(R) to treat patients with advanced cancers. A total of 18 patients were treated in the Phase I trial with REOLYSIN(R) at escalating dosages of 1x10(8), 3x10(8), 1x10(9), 3x10(9), 1x10(10) or 3x10(10) TCID TCID tissue culture infective dose; that amount of a pathogenic agent that will produce pathological change when inoculated on tissue cultures. (50). A maximum tolerated dose (MTD) was not reached and the treatment appears to have been well tolerated by the patients. The clinical trial is an open-label, dose-escalation Phase I study in which a single dose of REOLYSIN(R) was administered intravenously to patients diagnosed with selected advanced or metastatic solid tumours that are refractory (have not responded) to standard therapy or for which no curative standard therapy exists. The primary objective of the study is to determine the MTD, dose limiting toxicity and safety profile of REOLYSIN(R). Secondary objectives include the evaluation of viral replication, immune response to the virus and any evidence of anti-tumour activity. The principal investigator for the trial is Dr. Sanjay Goel, Assistant Professor and Attending Physician in the Department of Medical Oncology, Montefiore Medical Center Montefiore Medical Center, in the Bronx, New York, is the university hospital of the Albert Einstein College of Medicine. The hospital, named after Moses Montefiore, is one of the 50 largest employers in New York State [1]. and Albert Einstein College of Medicine
The Albert Einstein College of Medicine (AECOM) is a graduate school of Yeshiva University. It is a private medical school located in the Jack and Pearl Resnick Campus of Yeshiva University in the Morris Park , New York City New York City: see New York, city. New York City City (pop., 2000: 8,008,278), southeastern New York, at the mouth of the Hudson River. The largest city in the U.S. . About Oncolytics Biotech Inc. Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics' clinical program includes a variety of Phase I and Phase I/II human trials using REOLYSIN(R), its proprietary formulation of the human reovirus reovirus Any of a small group of animal and plant viruses that appear spheroidal and contain a core of RNA. Among the best-known genera are Orthoreovirus, Orbivirus, Rotavirus, and Phytoreovirus. The first three infect animals; the last can destroy rice, corn, and other crops. , alone and in combination with radiation. For more information, visit www.oncolyticsbiotech.com or call 403/670-7377. |
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