OFFLU network on avian influenza.
OFFLU is the name of the network of avian influenza avian influenza: see influenza. expertise inaugurated jointly in 2005 by the Food and Agriculture Organization of the United Nations Noun 1. Food and Agriculture Organization of the United Nations - the United Nations agency concerned with the international organization of food and agriculture
FAO, Food and Agriculture Organization and the World Organisation Noun 1. world organisation - an international alliance involving many different countries
global organization, international organisation, international organization, world organization for Animal Health, Achievements and constraints to date and plans for the future are described.
Many bird species are susceptible to infection with influenza A influenza A
Influenza caused by infection with a strain of influenza virus type A.
influenza A Infectious disease An avian virus, especially of ducks–which in China live near the pig reservoir and 'vector'; viruses. Aquatic birds form a major reservoir; they harbor representatives of all 16 hemagglutinin hemagglutinin /he·mag·glu·ti·nin/ (-gloo´ti-nin) an antibody that causes agglutination of erythrocytes.
cold hemagglutinin one which acts only at temperatures near 4° C. subtypes and 9 neuraminidase neuraminidase /neu·ra·min·i·dase/ (-ah-min´i-das) an enzyme of the surface coat of myxoviruses that destroys the neuraminic acid of the cell surface during attachment, thereby preventing hemagglutination. subtypes (1). Most of these viruses are of low pathogenicity, whether in wild or domesticated do·mes·ti·cate
tr.v. do·mes·ti·cat·ed, do·mes·ti·cat·ing, do·mes·ti·cates
1. To cause to feel comfortable at home; make domestic.
2. To adopt or make fit for domestic use or life.
a. bird species, and most do not cross-infect mammals. Strains of virus that are highly pathogenic for domestic poultry (chickens and turkeys) emerge from time to time and can cause epidemics with high death rates in affected flocks; clinical signs and pathologic lesions have been described (2). These highly pathogenic strains are almost invariably in·var·i·a·ble
Not changing or subject to change; constant.
in·vari·a·bil of hemagglutinin types 5 or 7 (H5 or H7), although low-pathogenic strains of H5 and H7 also circulate in wild birds and can infect poultry.
Outbreaks of H5 or H7 highly pathogenic avian influenza have occurred in recent years in different countries, including Italy, the Netherlands, Canada, and Mexico, but the most notable global event has been the progressive spread of highly pathogenic H5N1 virus, originally in Asia, then extending into parts of Europe and Africa. A feature of this virus is its ability to infect and kill human hosts, although so far it appears not to have spread substantially from human to human, apart from some possible family clusters. This spread has led to the mobilization of World Health Organization (WHO) and medical virology virology, study of viruses and their role in disease. Many viruses, such as animal RNA viruses and viruses that infect bacteria, or bacteriophages, have become useful laboratory tools in genetic studies and in work on the cellular metabolic control of gene expression forces worldwide to monitor the perceived threat of a potential human pandemic pandemic /pan·dem·ic/ (pan-dem´ik)
1. a widespread epidemic of a disease.
2. widely epidemic.
Epidemic over a wide geographic area.
For all its importance as a zoonotic Zoonotic
A disease which can be spread from animals to humans.
Mentioned in: Zoonosis threat, highly pathogenic avian influenza is a devastating dev·as·tate
tr.v. dev·as·tat·ed, dev·as·tat·ing, dev·as·tates
1. To lay waste; destroy.
2. To overwhelm; confound; stun: was devastated by the rude remark. disease of domestic poultry, which is one of the world's primary sources of animal protein, and the economic effects on livestock producers and rural communities in affected countries are enormous. All strains of H5 and H7 avian influenza viruses, plus any other H subtypes that show pathogenic traits in poultry, are formally notifiable notifiable /no·ti·fi·a·ble/ (no?ti-fi´ah-b'l) necessary to be reported to a government health agency.
necessary to be reported to the relevant government authority. Said of individual diseases. by national veterinary authorities to the World Organisation for Animal Health (OIE OIE Office International des Épizooties (French: International Office of Epizootics; Paris)
OIE Oficina Internacional de Epizootias (Spanish: World Organization for Animal Health) ) (4). Highly pathogenic avian influenza is among the transboundary animal diseases, which are a major concern for international organizations involved in disease surveillance and control, namely OIE and the Food and Agriculture Organization of the United Nations (FAO FAO,
n See Food and Agriculture Organization. ) (5).
Recognizing the global threat posed, particularly by the H5N1 epidemic, the international organizations OIE and FAO agreed in 2005 to establish a network of expertise to support international efforts to monitor and control this disease in poultry and other bird species. The network was designed from the start to interface with the existing WHO influenza network, which was focused on the threat to human health. The new animal influenza network was named OFFLU.
The originally stated objectives of OFFLU were to develop research on avian influenza, offer advice and veterinary expertise to member countries, and collaborate with the WHO animal influenza network. In the year since the network was established, the highest priority tasks have become exchanging scientific data and virus isolates (both within OFFLU and in liaison with the WHO network) and providing experts to assist with missions to affected countries. Developing research activities remains an essential need and will be pursued by individual participant institutions, either alone or in partnerships, but it is not the highest priority task for OFFLU itself.
The core of OFFLU is its scientific committee. Its members represent most of the world's expertise on avian influenza. The activities of the committee and the network are directed by a steering committee that represents key interests of the partner organizations, FAO and OIE. The network is supported by a secretariat, currently located at Padova, Italy, at an OIE/FAO reference center on avian influenza. The network has a philosophy of openness and is keen to involve scientific collaborators from as wide a field as possible. The core network is built around the OIE and FAO reference laboratories for avian influenza, but it is not limited to laboratories. Epidemiologists in particular have a role to play. Qualified persons and institutions are invited to register with the network as scientific collaborators. In addition, the network seeks to establish links with field experts with knowledge and experience of the global poultry industry and the control of infectious diseases, as well as with ornithologists This is a list of ornithologists who have articles, in alphabetical order by surname. See also . A-D
The relevance of OFFLU was recognized at the Beijing avian influenza pledging conference (6). However, funding is needed to empower and sustain this network. Without specific funding, its effectiveness will be limited. Veterinary and scientific expertise on avian influenza is in short supply given the scale of the current epidemic. Requests to FAO and OIE for expert missions to affected countries arrive on a regular basis, and demand exceeds supply. By establishing and extending the network, we hope that these pressures can be mitigated and needs, particularly for developing countries, can be adequately met. OFFLU itself does not send missions, but it provides a cadre of expertise to organizations that undertake this task.
The current priorities of OFFLU are to promote the collection, exchange, and characterization of animal influenza viruses, including the deposition of sequence data in genome banks. A good start has been made on this process, and it is a priority for further development. In addition, the network will seek to establish linkages between laboratories in industrialized in·dus·tri·al·ize
v. in·dus·tri·al·ized, in·dus·tri·al·iz·ing, in·dus·tri·al·iz·es
1. To develop industry in (a country or society, for example).
2. and developing countries to provide capacity building and training. The efforts to supply consistent, coordinated advice, expertise, and technical assistance to infected countries will continue. Research will continue on numerous fronts and will address scientific questions such as the molecular basis for virulence, factors involved in host specificity, basic and applied immunology including vaccine development, epidemiology, evaluation of control strategies, and the development of better diagnostic tests.
The network is facing several constraints, including heavy demand on limited resources, regulatory issues (e.g., problems with shipping viruses between countries), and the inevitable tensions between sharing information as a public good versus the desire to protect intellectual property rights. But after only 1 year in operation, the OFFLU network is already proving its effectiveness. It has an active website (www.offlu.net) as a primary means of communication, and it is well placed to channel the world's limited scientific resources to best effect in tackling this disease, which is of such great international concern for both animal and human health.
I am grateful for the support and constructive comments of the other members of the OFFLU steering committee, namely, Christianne Bruschke, Juan Lubroth, and Cristobal Zepeda.
The opinion expressed by authors contributing to this journal to not necessarily reflect the opinions of the Centers for Disease Control and Prevention Centers for Disease Control and Prevention (CDC), agency of the U.S. Public Health Service since 1973, with headquarters in Atlanta; it was established in 1946 as the Communicable Disease Center. or the institutions with which the authors are affiliated.
(1.) World Organisation for Animal Health. Manual of diagnostic tests and vaccines for terrestrial animals. 5th ed. 2005 Jul 8 [cited 2006 Jan 7]. Available from http://www.oie.int/eng/normes/mmanual/A_00037 .htm
(2.) Capua I, Mutinelli F. A colour atlas and text on avian influenza. Bologna, Italy: Papi Editore; 2001.
(3.) World Health Organization. Avian influenza. [cited 2006 Jun 7]. Available from http://www.who.int/csr/disease/avian_influenza/ en/index.html
(4.) World Organisation for Animal Health. Terrestrial animal health code. 14th ed. 2005 Jul 27 [cited 2006 Jun 7]. Available from http://www.oie.int/eng/normes/mcode/en_chapitre_2.7.12.htm
(5.) Food and Agriculture Organization, World Organisation for Animal Health, and the World Health Organization. A global strategy for the progressive control of highly pathogenic avian influenza (HPAI HPAI Highly Pathogenic Avian Influenza
HPAI Hospital Pharmacists Association, Ireland
HPAI Hewlett Packard Associates International ). 2005 Nov [cited 2006 Jun 7]. Available from http://www.fao.org/ag/ againfo/subjects/documents/ai/HPAIGlobalStrategy310ct05.pdf
(6.) Food and Agriculture Organization. Proposal for a global programme: avian influenza control and eradication. 2006 Mar 17 [cited 2006 Jun 7]. Available from http://www.fao.org/ag/againfo/subjects/ documents/ai/Global_Programme_Jan06.pdf
Address for correspondence: Steven Edwards, Veterinary Laboratories Agency The Veterinary Laboratories Agency (VLA) is an executive agency of the UK government department, the Department for Environment, Food and Rural Affairs(Defra). It carries out animal disease surveillance, diagnostic services and veterinary scientific research for government and , New Haw haw, common name for several plants, e.g., the hawthorn and the black haw (see honeysuckle). , Addlestone, Surrey, KT15 3NB, UK; email: email@example.com
Steven Edwards * ([dagger])
* Veterinary Laboratories Agency, Addlestone, United Kingdom; and ([dagger]) World Organisation for Animal Health, Paris, France
Dr Edwards is a veterinarian veterinarian /vet·er·i·nar·i·an/ (vet?er-i-nar´e-an) a person trained and authorized to practice veterinary medicine and surgery; a doctor of veterinary medicine.
n. with career experience in virology research and in the development and application of laboratory diagnostic tests. He is chief executive of the Veterinary Laboratories Agency (VLA) in the United Kingdom, president of the OIE Biological Standards Commission, and chair of the steering committee for OFFLU.