Noven Begins Phase II/III Clinical Trials for New Allergy Treatment.MIAMI--(BW HealthWire)--Sept. 16, 1997-- -- Transdermal Lidocaine lidocaine /li·do·caine/ (li´do-kan) an anesthetic with sedative, analgesic, and cardiac depressant properties, applied topically in the form of the base or hydrochloride salt as a local anesthetic; also used in the latter form as a Patch May Reduce Allergic Rhinitis Allergic Rhinitis Definition Allergic rhinitis, more commonly referred to as hay fever, is an inflammation of the nasal passages caused by allergic reaction to airborne substances. Symptoms -- Noven Pharmaceuticals Inc. (NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on :NOVN) announced Tuesday that it has begun Phase II/III clinical trials for a new treatment of allergic rhinitis symptoms utilizing the company's proprietary transoral lidocaine patch technology. Allergic rhinitis, which afflicts an estimated 50 million people nationally, is the inflammation of the nasal membrane caused by allergies. The symptoms of allergic rhinitis, nasal congestion nasal congestion ENT Difficulty in nasal breathing, due to an ↑ vascular thickness of nasal mucosa. See Nasal stuffiness. , sneezing To verbally tell somebody about a new and interesting Web site. See viral marketing. , sinus pressure and pain, and red watery eyes are caused by an allergic reaction to pollens (hay fever), mold, dust mites and other allergens. Allergic rhinitis accounts for more than $4 billion in U.S. health care costs annually and may be seasonal or chronic. A small group of physicians has evaluated patients with allergic rhinitis by applying a transoral patch containing an anesthetic (lidocaine) to the incisive papilla, the tiny ridge or bump on the roof of the mouth just behind the two front teeth. This ridge is a nerve ending which traverses each side of the nasal septum. It has been reported that nasal and sinus congestion The condition of a network when there is not enough bandwidth to support the current traffic load. congestion - When the offered load of a data communication path exceeds the capacity. , pressure and pain as well as burning and tearing eyes were relieved within minutes of a single application. Duration of effect lasted several hours to a few days. It is hypothesized that application of a topical anesthetic to the incisive papilla results in a reflex relief of nasal and sinus swelling and congestion. This response may occur by relieving the arteriolar arteriolar emanating from or pertaining to arteriole. and venular spasming in the nasal mucosa, thereby interrupting the cycle of cellular damage and the release of histamines. The method of treating nasal and sinus congestion when using topical anesthetics Anesthetics Drugs or methodologies used to make a body area free of sensation or pain. Mentioned in: Appendectomy applied to the palate is patented and Noven has an exclusive license to that patent. In addition, the company's patented transoral drug delivery system encompasses the administration of all anesthetics. Steven Sablotsky, Noven's president said: "We are now evaluating this exciting concept in placebo controlled clinical trials. If this new treatment proves efficacious it could be a valuable new product for Noven and the millions of allergy sufferers worldwide." Noven Pharmaceuticals Inc. is an industry leader in the development and commercialization of advanced drug delivery systems. Forward looking statements contained herein are qualified by and subject to the risks and uncertainties specified by Noven in its most recent periodic filings with the Securities and Exchange Commission. CONTACT: Noven Pharmaceuticals Inc. Mitchell Goldberg, 516/739-0536 |
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