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Novel surgical implant may prevent total blindness.

Byline: ANI

Washington, Feb 19 (ANI): Researchers at the University of Iowa Not to be confused with Iowa State University.
The first faculty offered instruction at the University in March 1855 to students in the Old Mechanics Building, situated where Seashore Hall is now. In September 1855, the student body numbered 124, of which, 41 were women.
 have tested and are now using a surgical implant called Retisert to prevent a rare eye condition, sympathetic ophthalmia.

Sympathetic ophthalmia occurs when vision is lost in one eye through injury or multiple surgeries, and the body's overactive immune system attacks the remaining healthy eye. If left untreated, a person can become completely blind.

However, researchers are using Retisert to prevent complete vision loss and eliminate dependence on systemic, or whole-body, immunosuppression immunosuppression

Suppression of immunity with drugs, usually to prevent rejection of an organ transplant. Its aim is to allow the recipient to accept the organ permanently with no unpleasant side effects.
.

Before use of the surgical technique, doctors had to 'shut down' a person's entire immune system to stop the attack on the remaining good eye.

"Until recently, the primary treatment option for sympathetic ophthalmia was non-surgical and involved high doses of oral steroids followed by oral immunosuppressive medication to preserve vision in a patient's remaining eye," said Vinit Mahajan Mahajan is an Indian surname, found among the Vaishya castes (business communities). In India surname Mahajan is used by two communities: - one residing in North of India(mainly on the Amritsar to Jammu belt) and another belonging to North Maharashtra. , M.D., Ph.D., assistant professor of ophthalmology and visual sciences at the University of Iowa Carver College of Medicine and a retinal surgeon with University of Iowa Hospitals and Clinics The University of Iowa Hospitals and Clinics (UIHC) is a 762-bed public teaching hospital and level 1 trauma center affiliated with the University of Iowa. UIHC is part of University of Iowa Health Care, a partnership between the University of Iowa Roy J. and Lucille A. .

"But this treatment, similar to organ transplantation cases, subjects patients to life-long use of immunosuppressive Immunosuppressive
Any agent that suppresses the immune response of an individual.

Mentioned in: Antirheumatic Drugs, Graft-vs.-Host Disease, Immunosuppressant Drugs


immunosuppressive

1. pertaining to or inducing immunosuppression.

2.
 drugs that have serious side effects such as osteoporosis, weight gain, potentially life-threatening infection and liver or kidney damage," he added.

The new Retisert treatment involves the surgical implantation into the endangered eye of a small plastic tab that contains a slow-release steroid called fluocinoloe acetonide.

The insert provides immunosuppression only to the endangered eye, not other body parts. It lasts for about two-and-a-half years and then can be replaced.

Mahajan tested Retisert by treating eight patients with sympathetic ophthalmia.

The device previously was studied in approximately 300 individuals who had a different immune system inflammation of the eye.

The UI-led study found that with Retisert, the eight patients reduced or eliminated use of systemic medications to control inflammation.

While two patients needed to resume using an oral immunosuppressive, vision improved or remained stable in all eight patients.

"Using Retisert, we are stabilizing vision in patients with sympathetic ophthalmia and getting them off the heavy-duty immunosuppressive medications," Mahajan said.

"Patients had been willing to put up with the serious side effects of systemic immunosuppression because if they lost vision in their remaining good eye, it would be totally life-altering. With Retisert, we can save the eye, and the side effects are limited to treatable risks of high pressure or cataracts in the eye," Mahajan added.

The study is published online in January in the journal Ophthalmology. (ANI)

Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency.  (ANI) - All Rights Reserved.

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Publication:Asian News International
Date:Feb 19, 2009
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