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Novel gene defect for colorectal cancer.

Six years after the genetic mutations that predispose some people to colorectal cancer were first identified, researchers have uncovered another, more unusual defect that can double a person's risk. This mutation is prevalent among Ashkenazi Jews, appearing in 6 percent of those tested.

The mutation changes the genetic spelling of the APC gene, which encodes a protein thought to participate in apoptosis, a process of cell death that keeps unchecked cell growth at bay. The mutation at first seemed minor. It changes a single amino acid, with apparently little effect on the protein's production or efficacy.

However, that small mutation lays a trap, the researchers found. When a cell replicates, the defect tends to scramble further the spelling of the mutated APC gene--and these subsequent variations encode truncated APC proteins that may not work at all.

"It creates a sort of Achilles' heel in the gene," says Kenneth W. Kinzler of Johns Hopkins Medical Institutions in Baltimore, a coauthor of the study, which appears in the September Nature Genetics. He compares the mutation to a bridge whose supporting beams have been sawed halfway through: The bridge may hold up for a while, but "eventually, something bad happens."

Researchers at Johns Hopkins came upon the mutation, designated I1307K, in a 39-year-old man who had a history of colorectal cancer but didn't carry any of the known colorectal cancer mutations discovered in the early 1990s. The person's mutation was considered a harmless polymorphism, one of many genetic variations in a population.

The scientists noted that the man was Jewish. When they began to look for the I1307K mutation in other colorectal cancer patients, they found it only in other Ashkenazi Jews.

The researchers tested blood samples from 243 healthy non-Jews and found that none of them had the mutation. Among 766 Ashkenazi Jews without known cancers, however, 6.1 percent carried I1307K. In a test of 211 Ashkenazi colorectal cancer patients, 10.4 percent had the mutation.

"Of any cancer-predisposing mutation in a defined population, this is by far the most prevalent," says Kenneth Offit of Memorial Sloan-Kettering Cancer Center in New York, a coauthor of the study.

Ashkenazi Jews moved north from the Mediterranean region after the fall of Rome and maintained their lineage in Central and Eastern Europe. They comprise roughly 85 percent of Jews worldwide. The newly discovered mutation reflects "a genetic legacy of 30 generations of relative isolation in Eastern Europe," Offit says.

There are at least 6 million Ashkenazi Jews in the United States, roughly 360,000 of whom could have the genetic mutation. Ashkenazi Jews have an estimated 8 to 15 percent chance of developing colorectal cancer in their lifetimes. For individuals who have the mutation, that chance climbs to 16 to 30 percent, according to the researchers.

Johns Hopkins now offers a $200 blood test that can detect the mutation.

The findings may lead researchers to reexamine some other polymorphisms. "Many polymorphisms that appear to be common and harmless in the population may need to be looked at more closely because they may predispose [an individual] to cancer in an unexpected way," Kinzler says. Other genetic variations could prove important in non-Jewish populations.

"[Our study] focuses attention on the familial risks of cancer," Offit says. He hopes the results will encourage families, Jewish or not, with histories of colorectal cancer to seek a colonoscopy, a procedure that detects precancerous polyps. These growths can be removed to prevent cancer.

Every year, up to 160,000 people in the United States are diagnosed with colorectal cancer, and roughly 60,000 die of it.
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Author:Seppa, Nathan
Publication:Science News
Date:Aug 30, 1997
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