Nosocomial dengue by mucocutaneous transmission.To the Editor: Wagner and colleagues report nosocomial nosocomial /noso·co·mi·al/ (nos?o-ko´me-il) pertaining to or originating in a hospital. nos·o·co·mi·al adj. 1. Of or relating to a hospital. 2. dengue dengue or breakbone fever or dandy fever Infectious, disabling mosquito-borne fever. Other symptoms include extreme joint pain and stiffness, intense pain behind the eyes, a return of fever after brief pause, and a characteristic rash. transmitted by needlestick and note that it is the fourth case of nosocomial dengue to their knowledge (1). In the same issue of Emerging Infectious Diseases, Nemes and colleagues report a separate case of nosocomial dengue also transmitted by needle-stick (2). Three other cases of nosocomial dengue transmission by needlestick have previously been published (3-5). We have recently published a case of nosocomial dengue infection that was transmitted by mucocutaneous mucocutaneous /mu·co·cu·ta·ne·ous/ (-ku-ta´ne-us) pertaining to or affecting the mucous membrane and the skin. mu·co·cu·ta·ne·ous adj. Of or relating to the skin and a mucous membrane. exposure to blood from a febrile traveler who had recently returned from Peru (6). During phlebotomy Phlebotomy Definition Phlebotomy is the act of drawing or removing blood from the circulatory system through a cut (incision) or puncture in order to obtain a sample for analysis and diagnosis. , a healthcare worker was splashed in the face with the traveler's blood. Both the traveler and the healthcare worker were subsequently found to have dengue fever dengue fever (dĕng`gē, –gā), acute infectious disease caused by four closely related viruses and transmitted by the bite of the Aedes mosquito; it is also known as breakbone fever and bone-crusher disease. with dengue virus type 3. This route of infection is biologically plausible because infection through mucosal surfaces (intranasal and oral routes) has been shown possible for arboviruses arboviruses (ar´bōvī´r  sz),n. (7). In our review of the literature, we also found a report of dengue virus transmission by bone marrow transplantation Bone Marrow Transplantation Definition The bone marrow—the sponge-like tissue found in the center of certain bones—contains stem cells that are the precursors of white blood cells, red blood cells, and platelets. (8). Other cases of transmission of dengue virus without a mosquito vector have occurred in 5 reported instances of infection in newborns as a result of intrapartum or vertical transmission from mother to child (9-12). We agree that nosocomial transmission ,nay become more common in temperate areas as more travelers return home with acute dengue fever. As Wagner and colleagues pointed out, travelers visiting Southeast Asia have the greatest risk of acquiring dengue infections because of the high endemicity of these viruses there. Our report further illustrates the occurrence of dengue infection in the Americas (13) and the risk for dengue to travelers visiting this region. Among 33 returned travelers with dengue infection reported in the United States in 1999 and 2000, 20 had acquired infection in the Caribbean islands (12 cases) or Central or South America (8 cases) (14). Clinicians and laboratorians should be alert to the possibility of acquiring infection with a dengue virus after needlestick or mucocutaneous blood exposure. The magnitude of nosocomial transmission in dengue-endemic areas is unknown and more difficult to assess because healthcare workers may be exposed to dengue virus infected mosquitoes outside the clinical setting. References (1.) Wagner D, de With K, Huzly D, Hufert F, Weidmann M, Breisinger S, et al. Nosocomial acquisition of dengue. Emerg Infect Dis. 2004;10:1872-3. (2.) Nemes Z, Kiss G, Madarassi EP, Peterfi Z, Ferenczi E, Bakonyi T, et al. Nosocomial transmission of dengue [letter]. Emerg Infect Dis. 2004;10:1880-1. (3.) de Wazieres B, Gil H, Vuitton DA, Dupond JL. Nosocomial transmission of dengue from a needlestick injury. Lancet. 1998;351:498. (4.) Hirsch JF, Deschamps C, Lhuillier M. Transmission metropolitaine d'une dengue par inoculation accidentelle hospitaliere. Ann Med Interne in·terne n. Variant of intern. (Paris). 1990; 141:629. (5.) Langgartner J, Audebert F, Scholmerich J, Gluck T. Dengue virus infection transmitted by needle stick injury. J Infect. 2002;44:269-70. (6.) Chen LH, Wilson ME. Transmission of dengue virus without a mosquito vector: nosocomial mucocutaneous transmission and other routes of transmission. Clin Infect , Dis. 2004;39:e56-60. (7.) Kuno G. Transmission of arboviruscs without involvement of arthropod arthropod Any member of the largest phylum, Arthropoda, in the animal kingdom. Arthropoda consists of more than one million known invertebrate species in four subphyla: Uniramia (five classes, including insects), Chelicerata (three classes, including arachnids and horseshoe vectors. Acta Virol. 2001;45:139-50. (8.) Rigau-Percz JG, Vorndam AV, Clark GG. The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. Am J Trop Med Hyg. 2001;64:67-74. (9.) Chye JK, Lim CT, Ng KB, Lim JMH JMH Jackson Memorial Hospital JMH Schaumburg, Illinois (Airport Code) JMH JSSIS Message Handler JMH James Monroe High school JMH Joint Message Holder (US DoD) , George R, Lain SK. Vertical transmission of dengue. Clin Infect Dis. 1997;25:1374-7. (10.) Kerdpanich A, Watanaveeradej V, Samakoses R, Chumnanvanakij S, Chulyamitporn T, Sumeksri P, et al. Perinatal dengue infection. Southeast Asian J Trop Med Public Health. 2001;32:488-93. (11.) Boussemart T, Babe R Sibille G, Neyret C, Berchel C. Prenatal transmission of dengue: two new cases. J Perinatol. 2001;21:255-7. (12.) Thaithumyanon P, Thisyakorn U, Deerojnawong J, Innis BL. Dengue infection complicated by severe hemorrhage and vertical transmission in a parturient parturient /par·tu·ri·ent/ (pahr-tu´re-ent) giving birth or pertaining to birth; by extension, a woman in labor. par·tu·ri·ent adj. 1. Of or relating to giving birth. 2. woman. Clin Infect Dis. 1994;18:248-9. (13.) Wilson ME, Chen LH. Dengue in the Americas. Dengue Bulletin. 2002;26: 44-61. (14.) Clark GG, Rigau-Perez JG, Vorndam V, Hayes JM. Imported dengue--United States, 1999 and 2000. MMWR MMWR Morbidity & Mortality Weekly Report Epidemiology A news bulletin published by the CDC, which provides epidemiologic data–eg, statistics on the incidence of AIDS, rabies, rubella, STDs and other communicable diseases, causes of mortality–eg, Morb Mortal Wkly Rep. 2002;51:281-3. Lin H. Chen * [dagger] and Mary E. Wilson * [dagger] * Mount Auburn Hospital, Cambridge, Massachusetts, USA; and [dagger] Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts. , Boston, Massachusetts, USA Address for correspondence: Lin H. Chum Travel Medicine Center, Division of Infectious Diseases, Mount Auburn Hospital, 330 Mount Auburn St, Cambridge, MA 02138, USA; fax: 617-499-5453; email: lchen@hms.harvard.edu |
|
||||||||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion