Nortran Pharmaceuticals: Phase II Clinical Trial Initiated.VANCOUVER, British Columbia--(BUSINESS WIRE)--July 20, 1998--Nortran Pharm.(VSE:NRT.) (OTC Bulletin Board OTC Bulletin Board An electronic quotation listing of the bid and asked prices of OTC stocks that do not meet the requirements to be listed on the NASDAQ stock-listing system. :NTRDF) Nortran Pharmaceuticals Inc. (the "Company") announced today that Phase II clinical trials on its local anaesthetic compound RSD921, have begun. The first in a series of 110 patients and volunteers received intradermal intradermal /in·tra·der·mal/ (-der´mal) 1. within the dermis. 2. intracutaneous. in·tra·der·mal adj. Within or between the layers of the skin. doses ranging from 0.05 percent - 0.25 percent of RSD921. The Principle Investigator of the trial is Dr. Chim Lang and the studies are being conducted in collaboration with Nortran's partner in Asia, the Chemical Company of Malaysia. The entire study will take place at the University of Malaya The University of Malaya (or Universiti Malaya in Malay; commonly abbreviated as UM) is the oldest university in Malaysia, and is situated on a 750 acre (3.0 km²) campus in southwest Kuala Lumpur, the capital city. in Petaling Jaya, Malaysia. The trial is comprised of a series of three studies, in which RSD921 will be administered in ascending doses to a total of 110 patients and volunteers over a 3 month period. The first study is to test the dermal effects of RSD921 (particularly for skin irritation), the second study will test RSD921 against a standard pain stimulus, and the third study will involve patients in which RSD921 is administered to prevent pain associated with transdermal cannulation can·nu·la·tion or can·nu·li·za·tion n. Insertion of a cannula. cannulation introduction of a cannula into a tubelike organ or body cavity. . All studies will use both lidocaine lidocaine /li·do·caine/ (li´do-kan) an anesthetic with sedative, analgesic, and cardiac depressant properties, applied topically in the form of the base or hydrochloride salt as a local anesthetic; also used in the latter form as a and placebo as controls. Nortran Pharmaceuticals is a drug discovery company focusing on pathology targeted small molecules. The Company recently announced a partnership with F. Hoffman La-Roche covering part of its antiarrhythmic antiarrhythmic /an·ti·ar·rhyth·mic/ (-ah-rith´mik) 1. preventing or alleviating cardiac arrhythmias. 2. an agent that so acts. an·ti·ar·rhyth·mic adj. development program. Nortran's current drugs in development target life-threatening arrhythmias of the heart, pain management, sexual dysfunction and acute cough. Chemical Company of Malaysia Berhad is a Malaysian public listed company with fertilizers, agrochemicals, industrial chemicals and healthcare as its core businesses. ON BEHALF OF THE BOARD Robert Rieder, Chief Executive Officer Warning: The Company relies on litigation protection for "forward looking" statements. The Vancouver Stock Exchange Vancouver Stock Exchange (VSE) A securities and options exchange in Vancouver, British Columbia, (Canada), specializing in venture capital companies. Vancouver Stock Exchange See Canadian Venture Exchange (CDNX). has not reviewed and does not accept responsibility for the adequacy or accuracy of this news release.
CONTACT: Nortran Pharmaceuticals Inc.
James King, 604/222-5577 or 1-800-330-9928
604/222-6617 (FAX)
URL: www.nortran.com
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