North America cans chlordane.

On 26 June 2003, the three North American environmental agencies announced that, through efforts coordinated by the North American Commission on Environmental Cooperation (NACEC), chlordane production and use has been eliminated continentwide. Once used on crops and lawns and in furniture factories to kill termites, chlordane is a persistent organic pollutant and has been classified by the U.S. EPA as a probable human carcinogen.

Following U.S. and Canadian chlordane bans in 1995, NACEC and EPA scientists worked with Mexico's National Institute of Ecology to develop and promote cost-effective methods for testing and monitoring chlordane use in Mexico and to educate farmers and furniture makers on viable alternatives. Mexico's ban was complete in December 1998; officials held this announcement until studies confirmed that chlordane use had ended in Mexico.