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Nonoxynol-9 dangers: health experts warn against rectal use.


On September 27 over 80 health experts and organizations released a letter warning against all rectal use of nonoxynol-9 (N-9)--a spermicide spermicide /sper·mi·cide/ (sper´mi-sid) an agent destructive to spermatozoa.spermici´dal

sper·mi·cide
n.
An agent that kills spermatozoa, especially as a contraceptive.
 mistakenly used to kill HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. , when actually it makes transmission worse. The letter came after a quiet campaign that persuaded most but not all manufacturers to remove the substance from their products. Experts agree that rectal use is dangerous and never appropriate--and that N-9 should not be included in any condoms or lubricant.

On October 10 the Bay Area Reporter, a San Francisco San Francisco (săn frănsĭs`kō), city (1990 pop. 723,959), coextensive with San Francisco co., W Calif., on the tip of a peninsula between the Pacific Ocean and San Francisco Bay, which are connected by the strait known as the Golden  gay newspaper, reported that all lubricant manufacturers had now promised to stop making lubricant with N-9. This followed an earlier series of articles in the B.A.R. that prompted some local retailers to remove N-9 products from their shelves.

From the September 27 consensus letter:

Call to Discontinue Nonoxynol-9 for Rectal Use

We, the undersigned un·der·signed  
adj.
1. Having signatures or a signature at the bottom or end. Used of documents.

2. Signed or having signed at the bottom or end of a document:
, in light of recent statements by the World Health Organization and the Centers for Disease Control, urge all people to cease the rectal use of products containing Nonoxynol-9 (N-9). We are concerned that many people mistakenly believe that N-9 provides extra protection against HIV and STDs when used rectally when in fact there is reason to think that rectal use of N-9 may increase risk of infection.

The Centers for Disease Control states: "N-9 can damage the cells lining the rectum, thus providing a portal of entry portal of entry,
n the area in which a microorganism enters the body. They may be cuts, lesions, injection sites, or natural body orifices.
 for HIV and other sexually transmissible transmissible /trans·mis·si·ble/ (trans-mis´i-b'l) capable of being transmitted.

trans·mis·si·ble
adj.
Capable of being conveyed from one person to another.
 agents. Therefore, N-9 should not be used as a microbicide or lubricant during anal sex."

The World Health Organization states: "N-9 should not be used rectally." (Further) "There is no published scientific evidence that N-9-lubricated condoms provide any additional protection against pregnancy or STIs compared with condoms lubricated lu·bri·cate  
v. lu·bri·cat·ed, lu·bri·cat·ing, lu·bri·cates

v.tr.
1. To apply a lubricant to.

2. To make slippery or smooth.

v.intr.
To act as a lubricant.
 with other products.

"Since adverse effects due to the addition of N-9 to condoms cannot be excluded, such condoms should no longer be promoted."

For More Information

* On September 25 The Wall Street Journal published "Some Makers, Venders Drop N-9 Spermicide on HIV Risk.

* The World Health Organization consensus report is at: http://www.who.int/reproductive-health/rtis/nonoxynol9.html

* And on September 28, 2002, The Lancet formally published results of a major study in Africa that showed that N-9 could increase HIV transmission--available at http://www.thelancet.com (free registration required).
COPYRIGHT 2002 John S. James
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Author:James, John S.
Publication:AIDS Treatment News
Date:Oct 18, 2002
Words:374
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