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Nextrials and Allon Therapeutics Set New Benchmark for Releasing Clinical Trial Results.


Allon uses Nextrials' Prism[R] to go from last patient visit to results in under seven weeks

SAN RAMON, Calif. -- Nextrials, Inc., a leader in clinical research software and services, today announced that its flagship Prism[R] clinical trial management software was used by Allon Therapeutics Inc. (TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
: NPC 1. (complexity) NPC - NP-complete.
2. (architecture) NPC - Next Program Counter.
) to successfully manage and analyze results of a Phase IIa trial of a novel treatment for Alzheimer's disease Alzheimer's disease (ăls`hī'mərz, ôls–), degenerative disease of nerve cells in the cerebral cortex that leads to atrophy of the brain and senile dementia. . Using the Prism software, results from Allon's nine-month, 16-site clinical trial were announced in less than seven weeks after the final patient visit -- a notable achievement within the biopharmaceutical R&D community.

Karole Sutherland, Allon's vice president, clinical operations, said Prism enabled Allon to institute efficiencies that improved collaboration, substantiated the data quality and accelerated the review and announcement of the trial results. "This was the first proof of human efficacy for our compound -- and for an emerging company such as Allon Therapeutics, it was important to release high quality data as quickly as possible to our shareholders and to the investment and medical communities," said Sutherland.

Sutherland added that unique Prism features, such as the patient randomization randomization (ranˈ·d·m  module, real-time project alerts and nightly data extracts, allowed Allon to track trial progress and data integrity on an ongoing basis. "Since it was a blinded trial, we did not know the outcome until the trial was closed. However, the responsiveness of the Nextrials team and the efficiencies provided by Prism ensured that the data was clean immediately upon database lock," she said.

James Rogers, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  and co-founder of Nextrials, said the company was able to work closely with Allon to close the study and lock the database in record time. "Seeing Allon successfully release its study results to the public in less than seven weeks after the final patient visit gives us additional proof that Prism can be a powerful ally in shortening the time to market for novel drugs and therapeutics," he said.

Attendees at the 44th Annual Meeting of the Drug Information Association, being held June 22-26 at the Boston (MA) Convention and Exhibition Center, can learn more about Nextrials' Prism by visiting Booth 1817.

About Allon Therapeutics Inc.

Allon Therapeutics Inc. is a clinical-stage biotechnology company developing treatments for major neurodegenerative conditions. In Q1 2008, Allon's drug AL-108 demonstrated human efficacy in amnestic mild cognitive impairment mild cognitive impairment (MCI),
n memory loss generally associated with aging; does not affect normal independent functioning of an individual.
, a precursor to Alzheimer's disease. Allon has Phase II human efficacy programs pursuing three large underserved markets: Alzheimer's disease, stroke and schizophrenia-related cognitive impairment. The company is listed on the Toronto Stock Exchange Toronto Stock Exchange (TSE)

Canada's largest stock exchange, trading approximately 1,200 company stocks and 33 options.
 under the trading symbol Trading symbol

See: Ticker symbol
 "NPC" (Neuro Protection Company(TM)) and based in Vancouver. For additional information please visit the company's website: www.allontherapeutics.com.

About Nextrials, Inc.

Founded by pharmaceutical researchers in 1999, Nextrials Innovates for Life[TM] by offering today's most novel products and services for speeding the delivery of life-saving drugs and medical devices to market. Prism([R]), its award-winning Electronic Data Capture (EDC EDC

See: Export Development Corp.
) solution, has been used at over 1,000 research sites to streamline the initiation and management of clinical trials. The company is headquartered in the San Francisco Bay area “Bay Area” redirects here. For other uses, see Bay Area (disambiguation).

The San Francisco Bay Area, colloquially known as the Bay Area or The Bay
. For more information, visit www.nextrials.com or call 925-355-3000. A podcast by co-founder and CEO James Rogers on the incorporation of electronic health records into the clinical trial process is also available at http://pharmavoice.com/podcasts.
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Publication:Business Wire
Date:Jun 16, 2008
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