New Study Offers Hope for Millions of Americans with Knee Osteoarthritis.VANCOUVER, Wash. -- Cardinal Nutrition: --First U.S.-Based Double-Blind, Placebo-Controlled Study of Methylsulfonylmethane (MSM MSM - Micronetics Standard MUMPS ) Published; Findings Show Popular Joint Health Supplement Safely Improves Pain and Physical Function --Findings Presented at the American College of Nutrition The American College of Nutrition (ACN) was established in 1959, to encourage the scientific investigation of nutrition. The ACN publishes, bi-monthly, the "Journal of the American College of Nutrition. Annual Meeting in Charleston, S.C.; Abstract Published in the Journal of the American College of Nutrition One in three Americans (nearly 66 million) experience joint discomfort on a daily basis due to arthritis(1). Of those, most experience pain in the knees, which can often be debilitating de·bil·i·tat·ing adj. Causing a loss of strength or energy. Debilitating Weakening, or reducing the strength of. Mentioned in: Stress Reduction . New study findings from the first published, U.S.-based, double-blind study double-blind study, n experimental technique in clinical research in which neither the researcher nor the patient knows whether the treatment administered is considered inactive (placebo) or active (medicinal). on MSM found the popular dietary supplement improved pain and function in people with knee osteoarthritis osteoarthritis or osteoarthrosis or degenerative joint disease Most common joint disorder, afflicting over 80% of those who reach age 70. It does not involve excessive inflammation and may have no symptoms, especially at first. when compared to placebo. The poster presentation titled, "A Randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. , Double-blind, Placebo-controlled Clinical Trial of Methylsulfonylmethane (MSM) for Knee Osteoarthritis Pain," was presented at the American College of Nutrition Annual Meeting in Charleston, S.C. this past Saturday. Vancouver, Wash.-based Cardinal Nutrition provided the active ingredient, OptiMSM(R). "Knee osteoarthritis affects millions of Americans' daily lives, and safe, effective options for relieving pain and restoring mobility are limited," said Jeremy Appleton, N.D., director of scientific affairs and research and development, Cardinal Nutrition. "The study results provide long-sought validation that MSM is a safe and effective option for people who want to improve their joint health." Study Details The randomized, double-blind, placebo-controlled clinical trial studied the efficacy and safety of MSM in fifty patients over age 40 diagnosed with knee osteoarthritis. Participants were randomized to take three grams, twice daily of OptiMSM or placebo for 12 weeks. Primary endpoints were the composite subscales in the Western Ontario and McMaster University Osteoarthritis Index (WOMAC WOMAC Western Ontario McMaster University Osteoarthritis Index Rheumatology An arthritic pain scoring system ranging from 0–no pain/disability to 100–most severe pain/disability ) on pain, stiffness, physical function, and total symptoms. Secondary endpoints included several laboratory tests for safety, serum homocysteine Homocysteine Definition Homocysteine is a naturally occurring amino acid found in blood plasma. High levels of homocysteine in the blood are believed to increase the chance of heart disease, stroke, Alzheimer's disease, and osteoporosis. (a risk factor for cardiovascular disease Cardiovascular disease Disease that affects the heart and blood vessels. Mentioned in: Lipoproteins Test cardiovascular disease ) and urine malondialdehyde (a marker of oxidative stress oxidative stress, n an imbalance of the prooxidant antioxidant ratio in which too few antioxidants are produced or ingested or too many oxidizing agents are produced. ). Results Compared to placebo, MSM produced statistically significant decreases in WOMAC pain and physical function impairment. MSM also significantly improved performance of daily activities when compared to placebo. Secondary outcomes included significant reductions in serum homocysteine and urine malondialdehyde in those taking MSM compared to placebo. Trends towards improvement in the MSM group compared to the placebo group were observed in nearly all other outcomes studied. There were no major adverse reactions adverse reactions, n.pl unfavorable reactions resulting from administration of a local anesthetic; responsible factors include the drug used, concentration, and route of administration. reported in the study. "We fully expected MSM to be effective in this study," said Appleton. "What's even more exciting is the secondary outcome surrounding homocysteine levels. The highly significant reduction in homocysteine is important, especially when several mainstream osteoarthritis drugs have been pulled off the market because they increase the risk of stroke and heart attack. By lowering homocysteine, MSM may actually reduce those risks, which is highly desirable in a joint supplement." Cardinal Nutrition, which manufactures OptiMSM, sponsored the trial and provided the active ingredient. The abstract highlighting the results of this study will be published in the October issue of the Journal of the American College of Nutrition. Details on the full study publication are expected soon. NOTE TO EDITOR: Copies of abstract and interviews with principal investigators available upon request. About OptiMSM OptiMSM is a heart-healthy, safe and effective joint health supplement. OptiMSM is manufactured in a dedicated U.S. facility certified for Good Manufacturing Practices and is rigorously tested by an independent third party to guarantee optimal purity. OptiMSM is found in products by major brand name manufacturers such as Schiff, Solgar, Natural Factors, Vitamin Shoppe, Jarrow, Source Naturals, Nature's Way and Enzymatic Therapy. Consumers can learn more about OptiMSM by visiting www.OptiMSM.com About Cardinal Nutrition Cardinal Nutrition is the world's leading manufacturer of licensed MSM, a key nutraceutical used to support joint health. Since 1989, Cardinal Nutrition has been at the vanguard for advancing MSM quality standards, education and research. As the MSM quality leader, Cardinal Nutrition is dedicated to continuously improving its products and processes to create MSM of unsurpassed purity. Cardinal's branded ingredient, OptiMSM, is preferred by medical and allied health professionals, and is the only North American North American named after North America. North American blastomycosis see North American blastomycosis. North American cattle tick see boophilusannulatus. MSM sold under license to worldwide R.J. Herschler MSM patents. (1)Arthritis Foundation, 2005 |
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