National Institute of Radiological Sciences Develops DNA Chip-based Risk Prediction System for Side-effect Occurrence in Cancer Radiation Therapy.Tokyo, Japan, Mar 31, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - The Frontier Research Center of the National Institute of Radiological Sciences (NIRS NIRS Near Infrared Spectroscopy NIRS Nuclear Information and Resource Service NIRS Near-Infrared Reflectance Spectroscopy NIRS National Institute of Radiological Science NIRS National Information and Reporting System NIRS National Informatics Recognition System ) has developed a system for predicting the occurrence of side-effects in cancer patients receiving radiation therapy. The new system uses a DNA chip DNA chip See DNA microarray. Noun 1. DNA chip - a microchip that holds DNA probes that form half of the DNA double helix and can recognize DNA from samples being tested gene chip to analyze 57 different genetic polymorphic polymorphic - polymorphism markers in blood DNAs. Then, the analysis results are input into a special database to determine the radiation sensitivity of subjects. The Center has developed the DNA chip using an allele-specific primer extension Primer extension is a technique whereby the 5' ends of RNA or DNA can be sequenced. In this technique, we need an oligonucleotide from a transcribed DNA sequence. This oligonucleotide is annealed to the mRNA. method in collaboration with Sumitomo Bakelite. The system does not require any special device. Rather, the procedure can be carried out with a constant-temperature device commonly used in clinical inspection and it only takes three hours to complete. The Center, which has so far analyzed 2,000 patients, plans to analyze an additional 1,000 patients to beef up the database. Further, it will proceed with further research with the aim of developing a similar system that can predict the risks of delayed side-effects in radiation therapy. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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