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Nanoviricides Go Beyond Antibodies in Fighting Bird Flu.


Completes Task of Destroying the Virus Particle

WEST HAVEN, Conn. -- NanoViricides, Inc. (OTC OTC

See: Over-the-counter.


OTC

See over-the-counter market (OTC).
 BB: NNVC.OB) (the "Company"), said it will be presenting new preclinical data at the 5th International Bird Flu Conference in Las Vegas on September 28th.

"Just like antibodies, nanoviricides[TM] have ligands that attach to the virus particle. However, unlike antibodies, nanoviricides complete the task of taking the virus apart. This is clearly visible in our electron microscopy (EM) studies," said Anil R. Diwan Noun 1. diwan - a Muslim council of state
divan

privy council - an advisory council to a ruler (especially to the British Crown)

2. diwan - a collection of Persian or Arabic poems (usually by one author)
divan
, Ph.D., President of the Company.

"We feel that nanoviricides are the next great advance beyond immunotherapeutics, (use of antibodies and gamma-globulins as treatments for diseases)," explained Dr. Eugene Seymour, MD, MPH, adding, "We have already shown that nanoviricides are superior to FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 approved antibodies in a rabies animal model. This has validated our approach as being the next evolutionary therapeutics platform after antibodies."

"Nanoviricides do not suffer from the major problems of antibodies and of vaccines as antiviral strategies," said Dr. Diwan. Antibodies are relatively specific to a particular virus strain or subtype. It is well known that HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.  and influenza viruses among many others, quickly escape antibodies. Vaccines depend upon the development of antibodies by the host, and thus, cannot protect efficiently against such changed viruses, as evidenced for influenzas.

FluCide[TM]-I is a broad-spectrum nanoviricide drug candidate based on a well-known ligand to which influenza viruses of all types must bind and cannot escape. Many other viruses and virus families also bind to this ligand and FluCide-I is expected to work against such viruses as well.

FluCide-HP is a broad-spectrum nanoviricide drug candidate based on well known "signature regions" called "polybasic polybasic /poly·ba·sic/ (-ba´sik) having several replaceable hydrogen atoms.

pol·y·ba·sic
adj.
 sites" on all HPAI HPAI Highly Pathogenic Avian Influenza
HPAI Hospital Pharmacists Association, Ireland
HPAI Hewlett Packard Associates International
 influenzas including H5N1 and H7N3. If the virus mutates Mutates
Undergoes a spontaneous change in the make-up of genes or chromosomes.

Mentioned in: Antiretroviral Drugs
 in this region to escape FluCide-HP, its pathogenicity will decrease and it will no longer be a dangerous epidemic threat. FluCide-HP has also shown very high efficacy against the unrelated rabies virus, which possesses similar signature regions.

"Our next step will be to perform animal studies against H5N1 to further validate our results," said Dr. Seymour, adding, "There have been delays in the commissioning of the BSL (language) BSL - A variant of IBM's PL/S systems language. Versions: BSL1, BSL2. 3+ animal facility in Vietnam. We are currently exploring other options that would permit the studies to be done in the US with the latest available H5N1 strain."

EM photographs of nanoviricides dismantling virus particles are on the Company's website (http://www.nanoviricides.com/action_small.html).

About NanoViricides:

NanoViricides, Inc. (www.nanoviricides.com) is a development stage company that is creating special purpose nanomaterials for viral therapy. The Company's novel nanoviricide[TM] class of drug candidates are designed to specifically attack enveloped en·vel·op  
tr.v. en·vel·oped, en·vel·op·ing, en·vel·ops
1. To enclose or encase completely with or as if with a covering: "Accompanying the darkness, a stillness envelops the city" 
 virus particles and to dismantle them. The Company is developing drugs against a number of viral diseases including H5N1 bird flu, seasonal influenza, HIV, hepatitis C, rabies, dengue fever dengue fever (dĕng`gē, –gā), acute infectious disease caused by four closely related viruses and transmitted by the bite of the Aedes mosquito; it is also known as breakbone fever and bone-crusher disease. , among others.

This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward looking statements are subject to known and unknown risks, uncertainties and other factors including the availability of adequate financing, the success of the Company's research and development strategy, the successful and timely completion of clinical studies and the uncertainties related to the regulatory process, described in the "Management's Discussion and Analysis Management's discussion and analysis (MD&A)

A report from management to shareholders that accompanies the firm's financial statements in the annual report. It explains the period's financial results and enables management to discuss topics that may not be apparent in the financial
" section of the Company's Form 10-KSB and other reports and filings with the Securities and Exchange Commission. Such risks, uncertainties and other factors may cause actual results, performance, or achievements of the Company to be different from those expressed or implied by the Company.
COPYRIGHT 2007 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2007, Gale Group. All rights reserved.

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Publication:Business Wire
Date:Sep 17, 2007
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