NanoHorizons Awarded Patent on QuickMass Technology.STATE COLLEGE, Pa. -- Invention Dramatically Extends MALDI MALDI Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer spectrometer Device for detecting and analyzing wavelengths of electromagnetic radiation, commonly used for molecular spectroscopy; more broadly, any of various instruments in which an emission (as of electromagnetic radiation or particles) is spread out according to some Performance; Enables MALDI MS Small Molecule Analysis and High-Throughput Screening High-throughput screening (HTS), is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Purpose and method NanoHorizons(TM), Inc., an emerging leader in applied nanoscale materials and solutions, announced today that it has been awarded a patent covering the company's deposited thin-film system for high-throughput small-molecule mass spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. . QuickMass(TM)-enhanced targets enable MALDI mass spectrometers to be used for accurate and convenient small molecule analysis using matrix-less and thin-layer matrix test techniques. "In applications where the mass range limits of MALDI mass spectrometers have forced analytic chemists to use slower and costlier analytic protocols, QuickMass-enhanced targets enable a leap in productivity and capability," said Dr. Stephen Fonash, founder of NanoHorizons. "Tens of millions of compounds are analyzed annually -- QuickMass-enhanced targets can rapidly impact a research lab or pharmaceutical company's bottom line and time-to-market." MALDI is currently the primary mass spectrometry technique for large molecule analysis, operating effectively in the 1,000 to 180,000 amu range. Prior to the advent of QuickMass, small molecule analysis could not be reliably performed using these laser-desorption-based mass spectrometers. Instead, small molecules could only be analyzed using slower and costlier Liquid Chromatography/Ion Electrospray analysis. QuickMass-enhanced targets utilize NanoHorizons' patented nanoscale non-porous germanium germanium (jərmā`nēəm) [from Germany], semimetallic chemical element; symbol Ge; at. no. 32; at. wt. 72.59; m.p. 937.4°C;; b.p. 2,830°C;; sp. gr. 5.323 at 25°C;; valence +2 or +4. layer to desorb desorb /de·sorb/ (de-sorb´) to remove a substance from the state of absorption or adsorption. desorb to remove a substance from the state of absorption or adsorption. the laser energy of the MALDI instrument, avoiding the use of a matrix and thereby allowing the acquisition of a clear spectrum below 1,000 amu. Using QuickMass+MALDI creates an 80% improvement in the time it takes researchers to get results. This translates into significant time and cost reductions for pharmaceutical development, ADME ADME Absorption, Distribution, Metabolism, and Excretion ADME Association of Destination Management Executives ADME Active Duty Medical Extension (Administration, Distribution, Metabolism, and Excretion) testing, biomarker, proteomics, bio/chemical hazard, environmental testing and numerous other applications. QuickMass-enhanced targets are intended to be used once and discarded or stored for archival purposes or further analysis at a later date. They require no special handling and can be stored "on the shelf" at room temperature indefinitely without degradation. Other notable attempts to enable "matrix-less MALDI" for small molecule analysis have relied on the use of porous silicon Porous Silicon (pSi) is a form of the chemical element silicon which has an introduced nanoporous holes in its microstructure, rendering a large surface to volume ratio in the order of 500m2/cm3. -- which has to date resulted in targets that demand complex cleaning, storage, handling and sample preparation procedures and are easily contaminated contaminated, v 1. made radioactive by the addition of small quantities of radioactive material. 2. made contaminated by adding infective or radiographic materials. 3. an infective surface or object. . "Single use targets are rapidly gaining popularity with high-volume users of MALDI instruments. Given the clear performance advantages of QuickMass, we believe all disposable targets should be QuickMass-enhanced." said Dr. Dan Hayes, co-founder of NanoHorizons and co-inventor of the QuickMass technology. "QuickMass-enhanced MALDI mass spectrometry will enable researchers to extend the useful range of their instruments and significantly speed up their discovery process, using existing equipment while avoiding complex handling, storage, cleaning, and anti-contamination procedures." QuickMass is already in use by Kratos Analytical, a wholly-owned subsidiary of Shimadzu Corporation and world leader in mass spectrometry. Questions regarding QuickMass and the availability of QuickMass-enhanced targets for additional brands and models of mass spectrometers can be answered by directly contacting NanoHorizons. For more information, please visit www.nanohorizons.com. About NanoHorizons, Inc. NanoHorizons, Inc. was founded in 2002 by Dr. Stephen Fonash, founder and Director of the Penn State Center for Nanotechnology Education Nanotechnology education is being offered by more and more universities around the world. The first program involving nanotechnology was offered by the University of Toronto's Engineering Science program, where nanotechnology could be taken as an option. and Utilization. The company focuses on nanotechnology applications With nanotechnology, a large set of materials and improved products rely on a change in the physical properties when the feature sizes are shrunk. Nanoparticles for example take advantage of their dramatically increased surface area to volume ratio. Their optical properties, e.g. in the drug discovery, microelectronics, consumer products and health care industries and has licensed a comprehensive portfolio of nanotechnology Intellectual Property from the Penn State Research Foundation. Its research and development team continuously produces additional real-life solutions using nanotechnology in applied materials Applied Materials, Inc. NASDAQ: AMAT (HKSE: 4336 ) is the global leader in nanomanufacturing technology solutions with a broad portfolio of innovative equipment, service and software products for the fabrication of semiconductor chips, flat panel solar displays, solar science. NanoHorizons' new product and application introductions include: QuickMass(TM), which addresses the need for more cost effective pharmaceutical research and increased drug discovery capacity; nano-materials-based sensors for applications such as environmental control, respiration monitors and medical diagnostics; and most recently low-cost, polymer process-compatible, noble-metal nanoparticles. For more information, please visit www.nanohorizons.com. |
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