NIH Awards Geospiza $1.1 Million to Re-Engineer Phrap, a Key Program in Genome Sequencing.Business Editors SEATTLE--(BUSINESS WIRE)--March 19, 2002 Geospiza, Inc. announced today that it received a $1.1 million SBIR SBIR Small Business Innovation Research (program/grant) SBIR Space Based Infra-Red SBIR Speaker-Boundary Interference SBIR Site Backsurface-referenced Ideal Plane/Range (silicon wafers) award to continue its collaboration with Southwest Parallel Software (SPS (Standby Power System) A UPS system that switches to battery backup upon detection of power failure. See UPS. SPS - Symbolic Programming System. Assembly language for IBM 1620. ) and re-engineer Phrap, a key program in genomic sequencing genomic sequencing The sequencing of the entire genome of an organism. A Closer Look The technique that allows researchers to read and decipher the genetic information found in the DNA of anything from bacteria to plants to animals is and SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily discovery. Phrap, developed by Dr. Phil Dr. Phil may refer to:
DNA sequencing often involves breaking DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. into short pieces and determining the DNA sequence DNA sequence Genetics The precise order of bases–A,T,G,C–in a segment of DNA, gene, chromosome, or an entire genome. See Base pair, Base sequence analysis, Chromosome, Gene, Genome. of each short piece. Researchers use Phrap to find where these short sequences overlap and assemble them into longer contiguous sequences that correspond to the original piece of DNA. Geospiza and SPS will improve Phrap's ability to use external information in the assembly process. Additional modifications will make it better suited for high-throughput data processing. In the past few years, the applications for Phrap have expanded to include a wide variety of genomics projects including SNP and mutation discovery, expression analysis, bacterial sequencing, and confirmatory sequencing. "Phrap was originally developed with a more narrow focus as a tool to assist genome centers sequencing cosmids," stated Dr. Todd Smith, president of Geospiza, "But people are using Phrap for new things now and the applications for Phrap have increased tremendously." Gary Montry, bioinformatics specialist, agrees, "As recognized by a grant reviewer, this is one of the most important projects of the post-genome era. Re-engineering Phrap will improve one of the most powerful tools in the genomics repertoire." Geospiza is a world leader in creating innovative data management software and has provided bioinformatics software, systems, and services to DNA sequencing laboratories worldwide since 1997. The company sells the Finch-Suite of bioinformatics components. For more information on Geospiza visit www.geospiza.com. Geospiza, the finch logo, and Finch(TM)-, Finch(TM)-Suite, Finch(TM)-Server are trademarks of Geospiza Inc. All other trademarks, service marks, and registered trademarks appearing herein are the properties of their respective owners and are hereby acknowledged. |
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