NIH AWARDS MORE THAN $54 MILLION TO KAISER PERMANENTE.As part of the $5 billion in grants announced by president Obama, the National Institutes of Health has granted Kaiser Permanente more than $54 million over two years through the American Recovery and Reinvestment Act to conduct health research on a multitude of critical public and clinical health areas. The bulk of this research will utilize and leverage Kaiser Permanente's electronic health records, the world's largest civilian electronic health record database. "Kaiser Permanente is proud to be part of what President Obama called the 'single largest boost to biomedical research in history.' It's our mission to find answers to medicine's complex questions so that everyone can have better care," said Raymond J. Baxter, Ph.D., senior vice president, Kaiser Permanente Community Benefit, Research and Health Policy. "Health research is foundational to reforming the way we deliver care. Such evidence-based innovation is core to Kaiser Permanente's commitment to improving care delivery and enhancing quality outcomes, two fundamental goals of the current health care reform debate." The NIH "Not invented here." See digispeak. NIH - The United States National Institutes of Health. has awarded 22 grants to Kaiser Permanente researchers in various regional centers, including a $25 million Grand Opportunities (GO) grant to conduct genotyping on 100,000 Kaiser Permanente members participating in the Research Program on Genes, Environment and Health, the largest population-based bio-bank in the United States. The RPGEH is based at the Kaiser Permanente Division of Research in Oakland, Calif. This genetic information will be linked to data on participants from RPGEH health surveys, disease registries and Kaiser Permanente's vast electronic health record database, resulting in a resource that will allow researchers to examine genetic and environmental influences on a wide variety of health conditions. The genotyping accomplished in collaboration with the University of California, San Francisco will roughly double the number of individuals in the United States available to researchers for genome-wide association studies. A separate NIH GO grant of nearly $4 million was awarded to the Kaiser Permanente Center for Health Research in Portland, Ore., to study personalized medicine and genomic tests for colon cancer colon cancer, cancer of any part of the colon (often called the large intestine). Colon cancer is the second most common cancer diagnosed in the United States. . Researchers will use the grant money to evaluate two tests, one that determines whether colon cancer patients will respond to a commonly prescribed drug and another that tests for a genetic mutation that dramatically increases the chance of developing colon cancer. Also awarded was a $7.2 million GO grant to develop a cardiovascular surveillance system for the Cardiovascular Research Network (a collaborative of 14 different health plans across the U.S. with approximately 11 million health maintenance organization members) and $3.3 million GO grant to create a National Research Database that will organize and leverage Kaiser Permanente's electronic health records. Other NIH grants include research and the building of resources aimed at better understanding the causes and treatment of autism autism (ô`tĭzəm), developmental disability resulting from a neurological disorder that affects the normal functioning of the brain. It is characterized by the abnormal development of communication skills, social skills, and reasoning. , autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma , breast cancer, chronic diseases, diabetes, heart disease, kidney disease Kidney Disease Definition Kidney disease is a general term for any damage that reduces the functioning of the kidney. Kidney disease is also called renal disease. , obesity, and successful aging; improving treatment for HIV-infected patients; better understanding the medical care burden of cancer; and improving post-acute care and rehabilitation for stroke patients. Other grants also will be used to study how to use natural language processing Natural language processing Computer analysis and generation of natural language text. The goal is to enable natural languages, such as English, French, or Japanese, to serve either as the medium through which users interact with computer systems such as to more accurately extract data from the electronic medical record. "We have a unique opportunity in front of us right now to transform and reform the way we deliver health care in this country," said John H. Cochran, MD, executive director of The Permanente Federation. "Kaiser Permanente believes that through evidence-based research and health information technology we can change how personalized health care is delivered." Details of the 22 grants are outlined on the next page. The American Recovery and Reinvestment Act provides an unprecedented level of funding ($8.2 billion in extramural extramural /ex·tra·mu·ral/ (-mur´il) situated or occurring outside the wall of an organ or structure. extramural situated or occurring outside the wall of an organ or structure. funding) to the NIH to help stimulate the U.S. economy through the support and advancement of scientific research. While NIH Institutes and Centers have broad flexibility to invest in many types of grant programs, they will follow the spirit of the ARRA by funding projects that will stimulate the economy, create or retain jobs, and have the potential for making scientific progress in two years. The National Institutes of Health - the nation's Medical Research Agency - includes 27 institutes and centers as a component of the U.S. Department of Health and Human Services Noun 1. Department of Health and Human Services - the United States federal department that administers all federal programs dealing with health and welfare; created in 1979 Health and Human Services, HHS . It is the primary funding agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information, visit http://www.nih.gov. About Kaiser Permanente Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services to improve the health of our members and the communities we serve. We currently serve 8.6 million members in nine states and the District of Columbia District of Columbia, federal district (2000 pop. 572,059, a 5.7% decrease in population since the 1990 census), 69 sq mi (179 sq km), on the east bank of the Potomac River, coextensive with the city of Washington, D.C. (the capital of the United States). . Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: www.kp.org/newscenter. APPENDIX of 22 NIH / ARRA GRANTS What follows is a brief description of each grant, broken down by Kaiser Permanente region. The numbers below reflect expected funding amounts over a two-year period, and may be subject to change. Kaiser Permanente - Northern California Division of Research -- $24,846,000 GO grant to conduct genotyping on 100,000 Kaiser Permanente members who are participating in the Research Program on Genes, Environment and Health, the largest population-based bio-bank in the United States, based at the Division of Research in Oakland, Calif. -- $7,217,106 GO grant to develop a surveillance system for cardiovascular disease Cardiovascular disease Disease that affects the heart and blood vessels. Mentioned in: Lipoproteins Test cardiovascular disease in the Cardiovascular Research Network. -- $3,362,771 GO grant to create National Research Database that will organize and leverage Kaiser Permanente's electronic health records on nearly 30 million current and past members in eight regions of the country. -- $4,971,981 GO grant to study contemporary treatment and outcomes for atrial fibrillation atrial fibrillation Irregular rhythm (arrhythmia) of contraction of the atria (upper heart chambers). The most common major arrhythmia, it may result as a consequence of increased fibrous tissue in the aging heart, of heart disease, or in association with severe infection. in clinical practice. -- $945,372 to study breast cancer survivorship survivorship n. the right to receive full title or ownership due to having survived another person. Survivorship is particularly applied to persons owning real property or other assets, such as bank accounts or stocks, in "joint tenancy. . -- $1,005,372 to extend and integrate the Kaiser Permanente electronic medical record to measure rehabilitation outcomes for stroke patients. -- $999,852 to study the management and outcomes of heart failure. -- $980,000 to study the effectiveness of immediate versus delayed use of metformin metformin /met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus. met·for·min n. in new-onset of type-2 diabetes. -- $999,370 to establish the Kaiser Permanente Autoimmune Disease Registry. -- $997,453 to study the cost effectiveness of hormonal therapy Hormonal therapy Use of hormone medications to inhibit menstruation and relieve the symptoms of endometriosis. Mentioned in: Endometriosis for clinically localized prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men. . -- $402,527 to extend an investigation of biologic markers for autism. -- $496,680 to improve understanding of the behavioral and social factors that impact adherence to diabetes care. -- $441,521 to better understand how comprehensive HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. services provided by a multidisciplinary care team may influence how well patients follow treatment recommendations. -- $102,277 to study the epidemiology, care and outcomes of patients with chronic renal insufficiency renal insufficiency A defect in renal ability to 'clear' waste products, a sign of inadequate glomerular filtration . -- $92,772 to study lactation lactation Production of milk by female mammals after giving birth. The milk is discharged by the mammary glands in the breasts. Hormones triggered by delivery of the placenta and by nursing stimulate milk production. and glucose tolerance after a pregnancy with gestational diabetes Gestational Diabetes Definition Gestational diabetes is a condition that occurs during pregnancy. Like other forms of diabetes, gestational diabetes involves a defect in the way the body processes and uses sugars (glucose) in the diet. . Kaiser Permanente Center for Health Research - Northwest -- $3,925,824 for comparative effectiveness comparative effectiveness, n the assessment of the relative merits of two active therapeutic approaches by direct comparison. research in genomic and personalized medicine for colon cancer. -- $996,603 to analyze five years of follow-up of data from a weight loss maintenance trial. -- $343,694 to compare the costs of cancer diagnosis and treatment in managed care vs fee-for-services systems. -- $316,000 to study what factors predict successful aging in elderly women. -- $99,971 to study how to use natural language processing to more accurately extract data from the electronic medical record. Kaiser Permanente - Colorado Institute for Health Research -- $184,501 for the Clinical Communication Research Center. Kaiser Permanente Center for Health Research - Georgia -- $339,604 to study how psychosocial stress decreases patient adherence to recommended care which may increase the risk of poor metabolic control and subsequent onset of chronic disease and obesity. For more information, visit http://www.kp.org or call 415/274-7926. |
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