NIEHS areas of special interest for 2004-2005.The NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) has identified the areas listed below as areas of special interest. These are areas that have not been the subject of requests for applications (RFAs) or program announcements (PAs) but that are of emerging importance in environmental health science. Applications in these areas will be given special consideration for funding. Potential applicants are encouraged to contact the appropriate scientific program administrator in the Division of Extramural extramural /ex·tra·mu·ral/ (-mur´il) situated or occurring outside the wall of an organ or structure. extramural situated or occurring outside the wall of an organ or structure. Research and Training for further information (see "For More Information," below). Obesity and the Environment Investigate the role of environmental agents in causing and/or exacerbating ex·ac·er·bate tr.v. ex·ac·er·bat·ed, ex·ac·er·bat·ing, ex·ac·er·bates To increase the severity, violence, or bitterness of; aggravate: obesity; develop intervention strategies by improving the built environment and developing sustainable communities Sustainable communities are communities planned, built, or modified to promote sustainable living. They tend to focus on environmental sustainability (including development and agriculture) and economic sustainability. . Translating Basic Biology to Clinical Studies and Environmental Medicine: The Connection of Environmental Exposures and Clinical Outcomes Build a research focus emphasizing the etiology and diagnosis of diseases that are due in part to environmental exposures; translate findings in animal models and in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. studies to the association of a clinical outcome with an environmental exposure. The Role of Epigenetics in Environmentally Induced Diseases and Dysfunctions Investigate the role of epigenetics in diseases and dysfunctions that exhibit an environmental component. Single-Nucleotide Polymorphisms and Disease Susceptibility Exploit and expand upon the resources developed in the Environmental Genome Project genome project 1 The Human Genome Project, see there 2. A general term for a coordinated research initiative for mapping and sequencing the genome of any organism , launching investigations of disease susceptibility resulting from environmental exposures. Environmental Health and the Biology of Aging Investigate how aging influences the interaction of environmental factors and individual susceptibilities. Comparative Toxicogenomics Define the comparative and integrated responses of organisms to environmental stimuli in order to improve our ability to predict and prevent adverse outcomes in humans. Systems Biology Systems biology, a field of study in the biosciences, focuses on the systematic study of complex interactions in biological systems. Particularly from 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Approaches to the Study of the Mechanism of Mixture Toxicity Develop pharmacokinetic and pharmacodynamic models that describe the effects of toxicants on biological systems using systems biology approaches. For more information | http://www.niehs.nih.gov/dert/programs/special/special.htm |
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