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Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus methicillin-resistant Staphylococcus aureus Methicillin-aminoglycoside resistant Staphylococcus aureus, MRSA An organism with multiple antibiotic resistances–eg, aminoglycosides, chloramphenicol, clindamycin, erythromycin, rifampin, tetracycline,  (MRSA MRSA Methicillin-resistant Staphylococcus aureus. See MARSA. ) continue to adapt to the selective pressure of antimicrobial agents and to exploit new niches, as evidenced by the recent isolation of strains with high-level vaneomycin resistance and the emergence of MRSA as a community pathogen. The combined use of the bacterial genotyping technique, multilocus sequence typing Multilocus sequence typing (MLST) is a technique in molecular biology for the typing of multiple loci. The procedure characterizes isolates of bacterial species using the DNA sequences of internal fragments of multiple (usually seven) housekeeping genes.  (MLST MLST Multi Locus Sequence Typing
MLST Medical Logistics Support Team
MLST Mini Losi Super Truck (1/18th scale radio control vehicle) 
), and characterization of the mobile methicillin-resistance determinant, staphylococcal staphylococcal

pertaining to Staphylococcus spp.

staphylococcal clumping test
used as a means of measuring the quantity of fibrinogen-split products in a sample of blood.
 chromosomal cassette mec (SCCmec), has provided new insights into MRSA strain nomenclature, evolution, and epidcmiology. The first MRSA emerged when SCCmec was acquired by an epidemic methicillin-susceptible strain prevalent in Europe. Acquisition of SCCmec by other successful strains has led to the emergence of at least 11 major epidemic MRSA strains belonging to five distinct lineages with a global geographic distribution. These five lineages have evolved both hospital-acquired and community-acquired MRSA, but some of the newly emerging community strains descend from other lineages.

Robinson DA, Enright MC. Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2004;10:92-7.
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Title Annotation:Molecular Epidemiology
Author:McDade, Joseph E.
Publication:Emerging Infectious Diseases
Article Type:Brief Article
Date:May 1, 2004
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