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Molecular Diagnostics, Inc. and DiagnoCure Inc. Enter Into Strategic Agreement.


Business Editors/Health & Medical Writers

InPath(TM) Slide Based Test to Automate Analysis

of ImmunoCyt(TM)/uCyt(TM) a non-invasive diagnostic

tool in the detection of Bladder Cancer bladder cancer

Malignant tumour of the bladder. The most significant risk factor associated with bladder cancer is smoking. Exposure to chemicals called arylamines, which are used in the leather, rubber, printing, and textiles industries, is another risk factor.
 

CHICAGO & QUEBEC CITY, Canada--(BUSINESS WIRE)--Dec. 12, 2002

Molecular Diagnostics, Inc. (OTCBB OTCBB

See OTC Bulletin Board (OTCBB).
:MCDG) and DiagnoCure Inc. (TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
:CUR) jointly announced today that they have entered into a Strategic Agreement to integrate DiagnoCure's ImmunoCyt(TM) / uCyt(TM) molecular assay for the detection and monitoring of bladder cancer with MDI's InPath(TM) Slide Based Test automated microscopy platform.

The Agreement is based around a three year relationship under which MDI (1) (Multiple Document Interface) A Windows function that allows an application to display and lets the user work with more than one document at the same time.  will optimize its SBT SBT Symplastin bleeding time  platform technology specifically for the detection of cells of interest based on staining by the ImmunoCyt(TM) / uCyt(TM) assay. The companies' plan for the program calls for initial product availability in the first quarter of 2003. The Agreement also calls for the companies to co-market the platform over that period to ImmunoCyt(TM) / uCyt(TM) customers worldwide. Financial terms of the Agreement were not identified.

"After an extensive evaluation of different automated microscopy tools and platforms, the Slide Based Test clearly provides the most integrated, cost-effective, and user-friendly platform available in the market today," said Pierre Desy, DiagnoCure's President and Chief Executive Officer. "We have been working with MDI's team for some time now and it is clear that they have a knowledge base that sets them apart in the field. We look forward to rapidly bringing to market an automated platform that will offer improved economies and efficiencies to our ImmunoCyt(TM) / uCyt(TM) customers, allowing them to build a new edge with their clinicians".

The InPath(TM) Slide Based Test is a fully integrated automated microscopy system, which includes a robotic microscope and advanced algorithmic software tools that are able to identify and quantify certain cellular attributes from microscopy samples. The SBT platform is currently in clinical trials for use with MDI's proprietary Cocktail-CVX(TM) biomolecular assay for the detection of cervical cancer Cervical Cancer Definition

Cervical cancer is a disease in which the cells of the cervix become abnormal and start to grow uncontrollably, forming tumors.
 and pre-cancer.

According to according to
prep.
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

3.
 Stephen G. Wasko, Molecular Diagnostic's President and COO, "DiagnoCure is on the leading edge of the evolving Urologic disease management field. Their recognition that automation of testing is crucial to rapid and broad market expansion and adoption of the new biomolecular technologies is in perfect alignment with MDI's assessment of the cancer detection and management market generally. We believe this partnership will demonstrate great rewards to both organizations and expect to be introducing this new technology to our common laboratory partners in the coming weeks."

DiagnoCure's biomolecular assay is an immunocytofluorescent assay for the detection of bladder cancer cells in urine and is based on a cocktail of three monoclonal antibodies This is a list of monoclonal antibodies, antibodies which are clones of a single parent cell. When used as medications, the generic names end in -mab (see "Nomenclature of monoclonal antibodies"). . With outstanding sensitivity results in both low and high-grade tumors, ImmunoCyt(TM) / uCyt(TM) is the perfect complement to cytology cytology (sītŏl`əjē), in biology, the study of the structure of all normal and abnormal components of cells and the changes, movements, and transformations of such components.  and cystoscopies in any bladder cancer monitoring program. The combination of ImmunoCyt(TM) / uCyt(TM) and cytology increases the confidence of clinicians making sure that they have not missed any cancer. uCyt+(TM) is currently distributed in Canada and in many European countries. In the United States, the test is marketed as ImmunoCyt(TM) under authorization from the FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 for monitoring recurrent bladder cancer.

About Molecular Diagnostics, Inc.

Molecular Diagnostics develops cost-effective cancer screening systems, which can be utilized in a laboratory or at the point-of-care, to assist in the early detection of cervical, gastrointestinal, and other cancers. The InPath(TM) System is being developed to provide medical practitioners with a highly accurate, low-cost, cervical cancer screening system that can be integrated into existing medical models or at the point-of-care. Other products include SAMBA(TM) Telemedicine software used for medical image processing, database and multimedia case management, telepathology and teleradiology. Molecular Diagnostics also makes certain aspects of its technology available to third parties for development of their own screening systems.

About DiagnoCure Inc.

DiagnoCure Inc. specializes in the development, production and commercialization of molecular tests for the detection of cancer. DiagnoCure's mission is to become the leading developer of highly accurate tests to enable the early detection of cancer.

DiagnoCure's first marketed product, ImmunoCyt(TM) / uCyt+(TM), is an immuno-cytofluorescence test for the detection of bladder cancer cells in urine and is based on monoclonal antibodies. This product is currently distributed in the United States, Canada and in many European countries. Combining its expertise in nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.  probe-based technology with its exclusive rights to the PCA (tool, programming) PCA - A dynamic analyser from DEC giving information on run-time performance and code use. 3DD3 gene technology, DiagnoCure is developing the uPM3(TM) test for detecting PCA3DD3 RNA RNA: see nucleic acid.
RNA
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
 expression in prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men.  cells that are present in urine. The uPM3(TM) test will be positioned as an ideal complement to the clinical management of the diagnosis of prostate cancer in order to decrease the number of unnecessary biopsies. As a result of a strategic partnership with Compugen Ltd., the company is also co-developing a molecular diagnostic test for lung cancer lung cancer, cancer that originates in the tissues of the lungs. Lung cancer is the leading cause of cancer death in the United States in both men and women. Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell. .

Certain statements in this release are forward-looking. These statements are based on DiagnoCure's and Molecular Diagnostics' current expectations and involve many risks and uncertainties, such as the possibility that clinical trials will not substantiate the Molecular Diagnostics' expectations with respect to the InPath(TM) System, and other factors set forth in reports and documents filed by Molecular Diagnostics with the Securities and Exchange Commission. Molecular Diagnostics and DiagnoCure undertake no obligation to publicly update or revise any forward-looking statements contained herein.
COPYRIGHT 2002 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1USA
Date:Dec 12, 2002
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