MegaNatural-AZ may offset cognitive decline.

Results of a new study published in the Journal of Neuroscience indicate a new grape seed extract formulation may support better brain function and help reduce memory loss.

Researchers at Mount Sinai School of Medicine collaborated with UCLA's Molecular Biology Institute and the director of the Polyphenolics division of Constellation Brands, a major producer of biologically active grape products. They set out to test the hypothesis that certain molecules contained in red wine, specifically in grape seeds currently being developed under the name of MegaNatural-AZ, might offset disease progression in mice genetically modified to develop Alzheimer's disease.

The study showed MegaNatural-AZ grape seed extract reduced Alzheimer's disease-type cognitive deterioration in the Alzheimer's disease mice through mechanisms that prevent the formation of a more complex form of a molecule known as amyloid in the brain. Complex amyloid build up can lead to Alzheimer's disease as well as memory impairment associated with dementia.

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