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Medicure Receives Patent Relating to Combination Products for Treatment of Hypertension.


Business Editors/Health/Medical Writers

WINNIPEG, Manitoba--(BUSINESS WIRE)--March 10, 2004

Medicure Inc. (TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
:MPH) (AMEX AMEX

See: American Stock Exchange
:MCU (1) (MicroController Unit) A computer on a single chip. See microcontroller.

(2) (Multipoint Control Unit) A device that is used to moderate a videoconference of three or more end points (users at computers or groups of users
), a cardiovascular drug discovery and development company, is pleased to announce the issuance of its tenth patent by the US Patent and Trademark Office. The newly issued patent, number 6,667,356, covers methods of treating hypertension with MC-1 in combination with various classes of anti-hypertensive drugs. It provides claims for composition combining MC-1 with another anti-hypertensive, including ACE inhibitors.

Entitled "Treatment of Cardiovascular and Related Pathologies," this patent provides intellectual property protection for Medicure's clinical product, MC-4232, which is being targeted for treatment of hypertension. It also provides protection for Medicure's other combination products currently in the Company's development pipeline.

"This new patent is one of the most significant in our Company's history," said Albert D. Friesen, PhD, Medicure's President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. . "It represents a major asset for the Company, protecting the integrity of MC-1 in combination products for the treatment of hypertension and other cardiovascular diseases, adding commercial value to our clinical products and strengthening our drug development pipeline."

Hypertension is a common disorder in which blood pressure remains abnormally high. Approximately 73% of the more than 50 million adult Americans who have hypertension, are not adequately treated. Recent studies have shown that despite substantial clinical research and refinements to existing pharmacological therapy, the ability to control hypertension remains at the same level as in the 1980s.

About Medicure Inc.

Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine. In addition to MC-4232, the Company is also conducting Phase II clinical trials with MC-1, which is focused on the prevention and treatment of ischemia, ischemic reperfusion ischemic reperfusion,
n the restoration of blood flow to an area that had previously experienced deficient blood flow. Oxidative stresses associated with this situation may cause damage to the affected tissues or organs.
 injury, and stroke. Medicure will be commencing a Phase II clinical trial with patients undergoing Coronary Artery Bypass Graft coronary artery bypass graft
n. Abbr. CABG
A surgical procedure in which a section of vein or other conduit is grafted between the aorta and a coronary artery below the region of an obstruction in that artery.
 (CABG CABG coronary artery bypass graft.

CABG
abbr.
coronary artery bypass graft


CABG Coronary artery bypass graft, see there
) surgery this spring. The cardiovascular market is the largest pharmaceutical sector with annual global sales of over US $70 billion.

The Company also has a medicinal chemistry-based Drug Discovery Program, which is similarly focused on advancing novel therapeutics to address unmet cardiovascular needs.

This News Release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
 provisions of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.
COPYRIGHT 2004 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1CANA
Date:Mar 10, 2004
Words:440
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