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Medication interventions for ADHD youth: a primer for school and mental health counselors.


This primer on the medical aspects of treating ADHD Attention-Deficit/Hyperactivity Disorder (ADHD) Definition

Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by distractibility, hyperactivity, impulsive behaviors, and the inability to remain focused on tasks or
 youth will help counselors feel better informed about the types of medications available, the possible side effects Side effects

Effects of a proposed project on other parts of the firm.
, and the advantages and disadvantages for use. In addition, we discuss the long- and short-term consequences for using interventions requiring medication alone, psychosocial interventions alone, or a combined, multimodal Two or more modes of operation. The term is used to refer to a myriad of functions and conditions in which two or more different methods, processes or forms of delivery are used. On the Web, it refers to asking for something one way and receiving the answer another; for example requesting  approach. Mental health and school counselors can partner to provide information to nurses, parents, physicians, and youth to design developmental interventions for our ADHD youth.

**********

Mental health counseling and school counseling roles are expanding to include not only working with ADHD youth, but also working with specific aspects of involvement related to their medication trials (James & Nims, 1996). For this reason, counselors need to know about medications and their side effects and about situations when drugs are either the sole intervention or when they are used in conjunction with psychosocial interventions. School counselors in particular may actually be expected to administer medications to youth, and they may do so in the belief that medication enables ADHD youth to better manage their classroom behavior. In many schools today, school counselors consider it their job to know about medications and their possible side effects. In fact, parents believe school counselors are competent in this role when counselors demonstrate knowledge in this area. If youth are to comply with their medication schedule, there often must be a person in the school who can administer and monitor its effect in youth as they proceed through their school day. When mental health and school counselors partner with school nurses, teachers, and parents to help youth manage their ADHD through the use of medication and psychosocial interventions, then youngsters often improve their academic performance.

School counselors are looking to team with other counseling professionals, including mental health counselors A mental health counselor is a professional who provides counseling to individuals, couples, families, groups, or larger systems. A mental health counselor may also have training in educational and vocational counseling (MacCluskie & Ingersoll 2001).  and marriage and family counselors to deliver more powerful intervention and prevention efforts in their schools. In fact, school comprehensive guidance programs encourage a team approach for delivering their services to all students, often involving at least a limited partnership with school staff, community counselors, and community members in order to effectively serve every child's academic, career, and personal/social needs. Consistent with this, school counselors may be expected to work with mental health counselors, family physicians, or with school nursing personnel to monitor the safe use of drugs for ADHD youth. This critical aspect of both intervention and prevention is necessary if our youth are to safely and effectively comply with their medical treatment protocol. With teachers suggesting to parents that youth could benefit from medication, it seems that schools are intimately involved with parents and children in determining whether or not medication is warranted. School counselors are often in the center of the communication hub related to treatment, care, and follow up of youth's progress and management of ADHD symptoms. Families decide whether or not to medicate med·i·cate
v.
1. To treat by medicine.

2. To tincture or permeate with a medicinal substance.
 a child based on perceived or actual severity of ADHD symptoms and their relation to problems at home, school, or with peers (Dulcan, Dunne, et al., 1997). For this reason, school personnel are intricately connected to the data gathering process associated with determining whether or not ADHD symptoms exist, symptom severity, and potential prevention or intervention efforts. Often, medication is the result of this complex process of detecting, treating, and monitoring ADHD symptoms.

The purpose of this article is to discuss the long- and short-term consequences of deciding to use interventions requiring medication alone, psychosocial interventions alone, or a combined, multimodal approach. Our hope is that mental health and school counselors can see how their roles as facilitators of communication between and among parties can ultimately improve the care of ADHD youth as they move from home, to school, to community. Even more, we hope that counselors can know their own views on this topic and be able to communicate their reasons for agreeing or disagreeing with the use of medication to help ADHD youth manage their academic and personal spheres of development. We do not advocate use or nonuse of medication. We simply advocate becoming informed so that mental health counselors can partner with school counselors as they take their rightful place as communication facilitators for parents, youth, teachers, and physicians who try to help ADHD youth live fuller lives.

Both mental health and school counselors are involved at some point in the process of gathering data, assisting with diagnosis or assessment, and determining a treatment plan for ADHD youth. When decisions are made to medicate, proper medical protocol requires careful comparison of a child's pre- and postbaseline performance in both the academic and behavioral domain. Several persons must monitor the effects of medication for impulsive ADHD youth who can neither be expected nor be allowed to self-manage their medication schedules. Several persons must also track specific potential negative effects in youth related to the use of medication such as low self-esteem, social isolation, dosage, and reliance on drugs. Monitoring is vital because research is contradictory regarding both the safety and effectiveness of medications. In fact, some of these drugs are even prescribed without FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 approval (James & Nims, 1996). Because ADHD children are seen for only parts of each day and by various people who interact in separate spheres of the child's worlds, someone must be designated as the "point person" who will communicate between and among these people so that continuity of care is accomplished. The mental health or school counselor may or may not be the point person, but they can see that someone serves in this capacity for these children.

In short, mental health and school counselors must know the most recent information regarding drug interventions with ADHD youth so that they can stay alert to signs that may suggest improved or diminished functioning in these children. This article is designed as an update on the use of medical interventions for ADHD and, as such, the information is technical yet necessary. To assist mental health counselors as consultants to school counselors and to provide them with accessible information for consultation purposes when working with parents or other school or medical personnel, we offer the following information on this vital topic, beginning with a description of how stimulants Stimulants
A class of drugs, including Ritalin, used to treat people with autism. They may make children calmer and better able to concentrate, but they also may limit growth or have other side effects.

Mentioned in: Autism
, tricyclic antidepressants Antidepressants, Tricyclic Definition

Tricyclic antidepressants are medicines that relieve mental depression.
Purpose

Since their discovery in the 1950s, tricyclic antidepressants have been used to treat mental depression.
, and nontricyclic depressants are used for treating ADHD symptoms.

STIMULANTS

Ritalin, Dexedrine, and Cylert

The use of stimulants in children is on the rise. Currently, more than 1.29 million children take some form of speed for ADHD, three of the most common of which are Ritalin (Methylphenidate methylphenidate /meth·yl·phen·i·date/ (meth?il-fen´i-dat) a central stimulant, used in the form of the hydrochloride salt in the treatment of attention-deficit in children and narcolepsy. ), Dexedrine (dextroamphetamine dextroamphetamine /dex·tro·am·phet·amine/ (dek?stro-am-fet´ah-men) the dextrorotatory isomer of amphetamine; used as the sulfate salt in the treatment of narcolepsy and attention-deficit. Abuse of this drug may lead to dependence. ), and Cylert (pemoline pemoline /pem·o·line/ (pem´ah-len) a central nervous system stimulant used in the treatment of attention-deficit.

pem·o·line
n.
). In one well-designed study, 75% of children and 57% of adolescents responded positively to Ritalin (O'Toole, Abramowitz, Morris, & Dulcan, 1997; Smith, Pelham Noun 1. Pelham - a bit with a bar mouthpiece that is designed to combine a curb and snaffle
bit - piece of metal held in horse's mouth by reins and used to control the horse while riding; "the horse was not accustomed to a bit"
, Gnagy, & Yudell, 1998). We do not know why medication use is 13% more effective in children than in adolescents because so few studies compare medical treatments of children with adolescents.

Psycho-stimulants are effective in improving quality of thought and desired behaviors, although behavior varies depending upon the child and the setting. So an ADHD child who improves in one area of functioning may not improve in another (Dulcan, Dunne, et al., 1997; Spencer et al., 1996). Our assessment of a stimulant's effectiveness is considered in relation to how severe are the side effects (Dulcan, Dunne, et al., 1997). Stimulants work by producing complex neuro-chemical changes at both the micro and macro levels, and involve systems as small as the individual neuron neuron, specialized cell in animals that, as a unit of the nervous system, carries information by receiving and transmitting electrical impulses.
neuron
 or nerve cell

Any of the cells of the nervous system.
 and as large as systems of interactions in several different neurotransmitter neurotransmitter, chemical that transmits information across the junction (synapse) that separates one nerve cell (neuron) from another nerve cell or a muscle. Neurotransmitters are stored in the nerve cell's bulbous end (axon).  action sites. Stimulants produce chemical changes that can last from 3 to 6 hours and can produce an on-off effect after each dosage that results in two or three jumps in functioning each day (Popper An early Unix POP server, which was written at the University of California at Berkeley. , 1997).

Currently, we have more questions than answers in terms of medical interventions with ADHD youth. For example, How can we tell which stimulant stimulant, any substance that causes an increase in activity in various parts of the nervous system or directly increases muscle activity. Cerebral, or psychic, stimulants act on the central nervous system and provide a temporary sense of alertness and well-being as  is right for treating ADHD? How does age interact over time with stimulant medication? Further, How do we assess the potential benefits of stimulant use when contrasted with their potential risks? We offer no simple formula for finding the right drug for a specific child or adolescent (Dulcan, Dunne, et al., 1997), but we offer the latest information about different drugs and their potential serious side effects, so that parents, teachers, mental health and school counselors can evaluate their own cost-benefit analysis cost-benefit analysis

In governmental planning and budgeting, the attempt to measure the social benefits of a proposed project in monetary terms and compare them with its costs.
 of whether or not medication will be a part of their children's lives. Even the FDA can only offer general guidelines, none of which are fail-safe, although they do provide minimum ages for approved stimulants.

Guidelines for use of Ritalin, Dexedrine, Cylert, and Adderall are included here for counselors to consider. Keep in mind that each medication has benefits and serious risks. Ritalin is the best studied, most used, and possibly most effective drug in reducing motor activity. Dexedrine, however, is longer lasting than Ritalin and therefore requires fewer administrations and so is less expensive, except for the fact that its use is often not reimbursed in third party formularies. Also, in general, Cylert is effective in treating ADHD and may be preferred over Dexedrine because it can be taken once a day, lasts from 4 to 10 hours, and has the least substance abuse potential of most stimulants. Although it is unusual a child to abuse the use of Ritalin or Dexedrine, family members or friends may potentially use the child's drugs (Riggs, Thompson, Mikulich, Whitmore, & Crowley, 1996). Although effective, we do not recommend Cylert as a first choice stimulant because it can cause liver failure liver failure Clinical medicine Liver insufficiency that results in death, requires a liver transplant, or is characterized by recovery after encephalopathy, or while awaiting a transplant; also defined as a condition with ≥ 3 of following: albumin < 3.  and death (Findling & Dogin, 1998). For yet another example, Adderall is an FDA-approved stimulant that was marketed for ADHD treatment in 1994, and that was formerly used as both an anti-obesity and minimal brain dysfunction min·i·mal brain dysfunction
n.
Attention deficit disorder. No longer in scientific use.


minimal brain dysfunction 
 drug in the 1960s under the name of Obetrol (Swanson et al., 1998). Although Adderall's combination of four different salts produce a dosage effect lasting 4 to 10 hours (similar to pemoline), the positive and negative effects of this drug require further testing (Popper, 1997).

Stimulant dosage. Using small doses to begin, and then titrating if necessary and depending upon the response to side effects, the correct dose is considered the one that uses the least dose yet obtains the maximum benefit with the least side effects (Dulcan, Dunne, et al., 1997). For example, with Ritalin, the dose lasts for 3 or 4 hours, and would start at 5 mg, with breakfast and lunch. Dexedrine is given at one-half to two-thirds the dosage of Ritalin and is also dispensed at breakfast and lunch. With Adderall, the dose lasts for 4 to 6 hours, is dispensed in the morning, and can be increased at a rate of 5 mg a week. In a final example, with Cylert, the dose lasts for 7 hours, and has a maximum daily dosage of 112.5 mg, beginning at 37.5 mg, with a possible increase of 18.75 mg a week. With stimulants other than Cylert, when higher doses are needed, the increase is at a rate of 5 mg to 10 mg per week (Findling & Dogin, 1998).

Positive effects. Often the first choice for treating ADHD, stimulant use is effective in producing short-term improvement in attention, in decreasing hyperactivity hyperactivity, excessive physical activity of emotional or physiological origin, usually seen in young children; one of the components of attention deficit hyperactivity disorder.  and impulsivity, in reversing side effects, in ease of adjusting dose, in effecting a speedy response, and in creating a positive responses with even a single dose (Dulcan, Dunne, et al., 1997). In comparison with other medications, only stimulants have shown consistent improvement in the attention components of symptoms associated with ADHD, and so they remain the drugs of choice to date (Popper, 1997).

Side effects. Side effects related to stimulant dose are a concern. However, when given enough time to work, when reduced, or when removed altogether, these side effects often disappear (Cantwell, 1996). Side effects can include decreased appetite or anorexia, insomnia, stomachaches, headaches, and irritability irritability /ir·ri·ta·bil·i·ty/ (ir?i-tah-bil´i-te) the quality of being irritable.

myotatic irritability  the ability of a muscle to contract in response to stretching.
. In this article, we discuss side effects such as growth problems, tic tic: see spasm.
tic

Sudden rapid, recurring muscle contraction—usually a blink, sniff, twitch, or shrug—always brief, irresistible, and localized. Frequency decreases from head to foot.
 development, drug abuse, increased blood pressure, and rebound effect rebound effect The worsening of Sx when a drug–eg, a decongestant, is discontinued, attributed to tissue dependence on the agent .

Regarding negative side effects related to growth, studies are contradictory. For example, Findling & Dogin (1998) quote research from a 1972 report suggesting that methylphenidate decreases children's height, but recent research suggests that ADHD itself, not the medications used to treat it, may cause a partial reduction in growth lasting through adolescence (Schachar, Tannock, Cunningham, & Corkum, 1997). Other research suggests that a decreased appetite may indeed cause some weight loss for those taking methylphenidate

Regarding negative side effects related to tic development, research indicates an increase in tic development in 9% of those who already have tic disorders and who also use stimulants. When dosage is stopped, less than 1% of those using stimulants actually develop a chronic tic disorder (Findling & Dogin, 1998). Recent research suggests that stimulants may in fact be safe and effective in improving ADHD in children with tic disorders.

Regarding negative side effects related to drug abuse, stimulant use is well-documented for its misuse as a recreational drug rec·re·a·tion·al drug
n.
A drug used nonmedically for personal enjoyment.


recreational drug Substance abuse Any agent–most have significant psychotropic effects–used without medical indications or
, street drug, or diet control drug; thus, except for Cylert, substance abuse is a concern (Popper, 1997).

Regarding negative side effects related to blood pressure and pulse rate pulse rate
n.
The rate of the pulse as observed in an artery, expressed as beats per minute.
, stimulant use can cause increased blood pressure in black adolescents, and so caution and increased monitoring must be employed for these youth (Findling & Dogin, 1998).

Finally, regarding negative side effects related to rebound behavior, stimulant use can exacerbate excitability excitability

readiness to respond to a stimulus; irritability.
, activity, talkativeness Talkativeness


Balwhidder

kind but loquacious Presbyterian clergyman. [Br. Lit.
, irritability, and insomnia if there is a sudden withdrawal of daily doses (Dulcan, Dunne, et al., 1997). Countering increased excitability is possible when we structure the child's activities, give a smaller dose in the afternoon, or use a longer lasting medication. One example of a stimulant with little rebound effect is Premoline, because it is given only once a day (Riggs et al., 1996).

Sustain-release stimulants. Some youth are embarrassed to take medication at school and so they do not comply with their medical protocol. When stimulants such as Ritalin and Dexedrine are used, additional doses are needed during the school day because they are shorter acting stimulants than those such as sustained-release methylphenidate and dextroamphetamine, which boast effects lasting up to 8 hours (Findling & Dogin, 1998). When longer acting stimulants are used, we are able to eliminate the need for in-school medications. Other options include the use of two doses of the standard Ritalin, which is more effective and more reliable than Ritalin-SR because Ritalin-SR is only available in 20 mg tablets and does not allow smaller doses. For some, two doses of the standard Ritalin is more effective and reliable than Ritalin-SR, but for others, it may take 2 hours before the medication takes effect (Dulcan, Dunne, et al., 1997). Another consideration is that both Ritalin-SR and Dexedrine Spansule derive the sustained gradual release from special coated tablets (Findling & Dogin, 1998), which, if chewed, could lose the time-release action and could cause adverse effects. An advantage of Dexedrine Spansule over Ritalin-SR is a greater range of doses, with 5, 10, and 15 mg tablets.

Stimulant concerns. Positive effects of stimulant use include short-term effectiveness, fewer irrelevant activities and disturbances, and more compliance and attention (Richters et al., 1995). However, two difficulties with stimulant use are that there is no long-term effectiveness and that parents often do not see the positive behaviors at home that are evident in school. Regarding the latter, one study attempted to determine behavioral, situational, and temporal effects of methylphenidate treatment in ADHD. For this study, both teachers and parents rated the behavior of their children. Teachers found that the treatment group's behavior improved more than the placebo group and saw no increase in side effects; however, parents saw no improvement in the behavior in either the treatment group or in the placebo group and saw an increase in side effects (Schachar et al., 1997). Perhaps the medication had worn off by the time the children got home or perhaps improved behavior at home was the result of improved self-esteem from having a successful school day. So, stimulants are only effective in the short term, and there is a difference in the way teachers and parents view the benefits of stimulant use, with teachers seeing more of an advantage for the use of stimulants than parents.

Tricyclic Antidepressants

Stimulants appear to be safe and effective and so are prescribed more than any other medication for treating ADHD (Findling & Dogin, 1998). However, side effects exist because these are short-acting medications that require multiple daily doses. Needing to take medication while in school can lead to both noncompliance noncompliance

failure of the owner to follow instructions, particularly in administering medication as prescribed; a cause of a less than expected response to treatment.

noncompliance 
 and social embarrassment (Wilens, Biederman, Geist, Steingard, & Spencer, 1993). In addition, stimulants do not work for about 25% of all children, and multiple doses do not work for up to 15% of these children (Findling & Dogin, 1998; Popper, 1997). Therefore, we need safe, effective medication that can be used when stimulants fail. One alternative to the use of stimulants is the use of antidepressants Antidepressants
Medications prescribed to relieve major depression. Classes of antidepressants include selective serotonin reuptake inhibitors (fluoxetine/Prozac, sertraline/Zoloft), tricyclics (amitriptyline/ Elavil), MAOIs (phenelzine/Nardil), and heterocyclics
, especially the tricyclic antidepressants (TCAs). School counselors need to know that TCAs are gaining popularity in mental health counseling settings today (Wilens et al., 1993), and so counselors need to think about what effects, both positive and negative, their use could have on youth, and about what needs may arise in the school setting as their use becomes more widespread.

Imipramine imipramine /imip·ra·mine/ (i-mip´rah-men) a tricyclic antidepressant of the dibenzazepine class, used as i. hydrochloride or i. pamoate. , amitriptyline amitriptyline /am·i·trip·ty·line/ (am?i-trip´ti-len) a tricyclic antidepressant with sedative effects; also used in treating enuresis, chronic pain, peptic ulcer, and bulimia nervosa. , desipramine desipramine /de·sip·ra·mine/ (des-ip´rah-men) a tricyclic antidepressant of the dibenzazepine class; used as the hydrochloride salt.

desipramine

a tricyclic antidepressant.
, and nortriptyline nortriptyline /nor·trip·ty·line/ (nor-trip´ti-len) a tricyclic antidepressant, used as the hydrochloride salt to treat depression and panic disorder and to relieve chronic severe pain. . TCAs do have a narrow margin of safety, but they may be an option for those who do not respond to stimulants, have severe depression, suffer side effects from stimulant use, or have tics or Tourette's disorder (Dulcan, Dunne, et al., 1997). Several tricyclic antidepressants are prescribed, but some of the common medications include the tertiary amines amines (mēnz´),
n.pl organic compounds that contain nitrogen.
 like imipramine (Tofranil) and amitriptyline (Elavil) and secondary amines like desipramine (Norpramine) and nortriptyline (Aventyl; James & Nims, 1996). Antidepressant antidepressant, any of a wide range of drugs used to treat psychic depression. They are given to elevate mood, counter suicidal thoughts, and increase the effectiveness of psychotherapy.  medication increases the supply of the neurotransmitters Neurotransmitters
Chemicals within the nervous system that transmit information from or between nerve cells.

Mentioned in: Bulimia Nervosa, Impotence, Pain, Withdrawal Syndromes
 norepinephrine norepinephrine (nôr'ĕpīnĕf`rən), a neurotransmitter in the catecholamine family that mediates chemical communication in the sympathetic nervous system, a branch of the autonomic nervous system.  and serotonin serotonin (sĕr'ətō`nĭn), organic compound that was first recognized as a powerful vasoconstrictor occurring in blood serum. It was partially purified, crystallized, and named in 1948, and its structure was deduced a year later.  by blocking the reuptake reuptake /re·up·take/ (re-up´tak) reabsorption of a previously secreted substance.

re·up·take
n.
 of these neurotransmitters (Biederman, 1998).

Positive effects. Tricyclic antidepressants (TCAs) function similarly to longer acting stimulants (Popper, 1997) and appear to be therapeutic. Spencer et al. (1996) reviewed 29 studies to determine the effectiveness of TCAs for treating ADHD. Twenty-six studies looked at the effect of TCA TCA

1. trichloroacetic acid.

2. tricarboxylic acid cycle (Krebs cycle).

TCA Tricyclic antidepressant, see there
 in treating young school children, one in treating adolescents, and two in treating adults. Almost all (93%) showed moderate improvement for ADHD symptoms (Biederman, 1998). Based on these findings, TCAs may be considered a drug of second choice when people do not respond to stimulants (Wilens et al., 1993).

Some advantages of using TCAs over stimulants include a longer half-life (therefore fewer doses per day are needed), minimal abuse, and less co-morbid anxiety and depression with ADHD (Wilens et al., 1993). In addition, hyperactivity, impulsivity and rebound effects all decrease with TCA (Cantwell, 1996). Critics argue, however, that such positive effect on cognition and attention do not hold in repeated studies (Popper, 1997). The available literature suggests that TCAs are as effective as stimulants in managing behaviors connected with ADHD, but they may be less effective in improving cognition (Biederman, 1998).

TCAs and co-morbidity. Tic disorders can be simple motor tics or complex motor and vocal tics called Tourette's syndrome Tou·rette's syndrome or Tou·rette syndrome
n.
A severe neurological disorder characterized by multiple facial and other body tics, usually beginning in childhood or adolescence and often accompanied by grunts and compulsive utterances, as of
 (TS). Ten percent of ADHD children may have a tic disorder while 50% of children with TS may also have ADHD. For children with both tics and ADHD, stimulants do not work well (Spencer, Biederman, Wilens, Steingard, & Geist, 1993). In such cases, tricyclic antidepressants such as nortriptyline appear to work better. For example, Massachusetts General Hospital Massachusetts General Hospital Health care The major teaching hospital for Harvard Medical School, widely regarded as one of the best health care centers in the world  investigated TCAs as an alternative treatment for children with ADHD and tic symptoms and reviewed cases where patients with tic disorders and ADHD were treated with desipramine and nortriptyline. TCAs were associated with improvement, even in patients who had previously failed to respond to desipramine. Recent research also suggests that nortriptyline may help co-morbid anxiety and major depressive disorder Major depressive disorder
A mood disorder characterized by profound feelings of sadness or despair.

Mentioned in: Conduct Disorder

major depressive disorder 
 (MDD MDD Major depressive disorder, see there ) with ADHD, which could lead to treating co-morbid disorders, associated with TS patients (Spencer, Biederman, Wilens, et al., 1993).

Side effects. Even with the advantages, TCAs have side effects such as low blood pressure, dry mouth, constipation, dry eyes A condition in which the eyes feel dry or have a burning or stinging sensation due to an insufficient amount of tears. Dry eyes can be caused by the lack of blinking, which often occurs when users stare at a computer screen. , nasal congestion nasal congestion ENT Difficulty in nasal breathing, due to an ↑ vascular thickness of nasal mucosa. See Nasal stuffiness. , dizziness, unsteadiness, and drowsiness drows·i·ness
n.
A state of impaired awareness associated with a desire or inclination to sleep. Also called hypnesthesia.


drowsiness Medtalk Semiconsciousness; grogginess, sleepiness
 (James & Nims, 1996). People taking TCAs must be monitored for cardiovascular problems, potential cardiac problems, accidental or intentional overdose, possible ineffectiveness over time, and risk of hypertension (Wilens et al., 1993; Dulcan, Dunne, et al., 1997). For these reasons, secondary amines (such as nortriptyline and desipramine) are preferred because of reduced side effects. However, overdosing is a serious problem with the tricyclic antidepressants, with desipramine having the highest risk (Popper, 1997). Specifically, death by desipramine overdose is high (1%) in both children and adults. So, parents must carefully observe their children when using tricyclic antidepressants, and they must take care to keep the medication in a safe place so that overdose is less likely.

TCAs deaths. Benefits of using tricyclic antidepressant tri·cy·clic antidepressant
n.
Any of a class of antidepressants, such as amitriptyline, that are structurally related to the phenothiazine antipsychotics.
 may be outweighed by the sudden, unexplained death of seven children, ages 7 through 15, where six had used desipramine and one imipramine, and where none had previous cardiovascular problems (Varley & McClellan, 1997). If using TCAs, it is critical that cardiac functioning is carefully monitored, from baseline through follow-up electrocardiogram electrocardiogram /elec·tro·car·dio·gram/ (-kahr´de-o-gram?) a graphic tracing of the variations in electrical potential caused by the excitation of the heart muscle and detected at the body surface.  (ECG ECG electrocardiogram.

ECG
abbr.
1. electrocardiogram

2. electrocardiograph


ECG
Also called an electrocardiogram, it records the electrical activity of the heart.
). In addition, it is essential that pulse, blood pressure, and drug blood levels are monitored. Although no causal relationship has connected these deaths to TCA use--but since all TCAs treat ADHD behavioral symptoms equally--the use of desipramine may be an unwise choice (Popper, 1997). Awareness of these deaths lead us to question whether it is ever right to recommend TCAs for use in ADHD treatment even if they are effective (Varley & McClellan, 1997). Informed consent should precede TCA use. Mental health counselors can work with school counselors to warn youth and their parents of TCA use and the side effects that could lead to death.

Mental health and school counselors can also help parents understand that the pharmacological properties of TCAs are not the same in children as in adults (Dulcan, Dunne, et al., 1997). Children have a smaller fat-to-muscle ratio and so are not protected from an excessive dosage because they have less fat in which to store the drug. Also, relative to body size, children have a larger liver that causes faster metabolism and more rapid absorption. Because of this, children will probably need a higher TCA dosage than adults.

So, with everything considered, it may be the case that too many risks are associated with using tricyclic antidepressants. Although mental health counselors, school counselors, parents, and doctors can help the ADHD child attain positive results through medication use, keep in mind that even small risks must be considered carefully. Although TCAs (except for desipramine) offer certain advantages over stimulants, stimulants still appear to be the first choice for treating ADHD.

Nontricyclic Antidepressants

Research on other medications for ADHD treatment is limited. Nevertheless, two nontricyclic antidepressants that show potential are bupropion bupropion /bu·pro·pi·on/ (bu-pro´pe-on) a monocyclic compound structurally similar to amphetamine, used as the hydrochloride salt as an antidepressant and as an aid in smoking cessation.  and monoamine oxidase Monoamine oxidase

Either of two enzymes found in the outer membrane of mitochondria that degrade biogenic amines and are thus responsible for the destruction of transmitter substances at neuronal synapses.
.

Bupropion. Bupropion can reduce ADHD symptoms in children (Findling & Dogin, 1998). In a study using bupropion, hyperactivity, impulsivity, and cognition improved (Popper, 1997). Barrickman et al. (1995) compared the effectiveness of bupropion to that of Ritalin in treating children with ADHD and found that both were effective, and Ritalin was better. Bupropion might be used as an alternative to Ritalin when children cannot take Ritalin because of stimulant allergies, drug reaction, no tolerance to stimulants, or no response to treatment. Side effects in adults that may generalize generalize /gen·er·al·ize/ (-iz)
1. to spread throughout the body, as when local disease becomes systemic.

2. to form a general principle; to reason inductively.
 to children taking bupropion may include aggravating ag·gra·vate  
tr.v. ag·gra·vat·ed, ag·gra·vat·ing, ag·gra·vates
1. To make worse or more troublesome.

2. To rouse to exasperation or anger; provoke. See Synonyms at annoy.
 tics, skin rash, or seizure. Reducing dosage may reduce these side effects.

Monoamine oxidase. Preliminary studies on monoamine oxidase used by youth with ADHD revealed improvement in 90% of the 29 children who participated and no serious side effects (Biederman, 1998). Problems associated with this study included restrictive diet risks (most cheeses) and negative drug interaction between monoamine oxidase and cold medicines and amphetamines Amphetamines
Sympathomimetic amines; sometimes called speed; synthetic chemicals that stimulate the central nervous system.

Mentioned in: Weight Loss Drugs

amphetamines
.

Alpha 2 Agonist agonist /ag·o·nist/ (ag´ah-nist)
1. one involved in a struggle or competition.

2. agonistic muscle.

3.
 

Clonidine clonidine /clo·ni·dine/ (klo´ni-den) a centrally acting antihypertensive agent, used as the hydrochloride salt; also used in the prophylaxis of migraine and the treatment of dysmenorrhea, menopausal symptoms, opioid withdrawal, and . The alpha 2-agonist clonidine is used to treat ADHD in children in spite of weak scientific evidence for its use, and in spite of a paucity of studies dealing with its effects (Popper, 1997). Although Clonidine can eliminate insomnia caused by ADHD, and although behavioral response has demonstrated benefits, inattention in·at·ten·tion  
n.
Lack of attention, notice, or regard.

Noun 1. inattention - lack of attention
basic cognitive process - cognitive processes involved in obtaining and storing knowledge
 and cognition results were less decisive (Biederman, 1998). Before recommending Clonidine (methylphenidate), a doctor must conduct a complete cardiovascular history, including cardiac examination, pulse and blood pressure check, and blood count because of reports of unexpected sudden death. In addition, side effects include sedation Sedation Definition

Sedation is the act of calming by administration of a sedative. A sedative is a medication that commonly induces the nervous system to calm.
Purpose

The process of sedation has two primary intentions.
, rebound (Popper, 1997), and cardiovascular effects (Dulcan, Dunne, et al., 1997). To reduce side effects, clonidine needs to be administered in gradual, frequent doses (Findling & Dogin, 1998).

Clonidine patch. Clonidine lasts from 3 to 6 hours and requires three to four doses a day (Broderick-Cantwell, 1999). An alternative is the clonidine patch, which is replaced every 5 days. Advantages to the use of the patch include less frequent dosages, eliminating the rebound effect, allowing even drug distribution, reducing side effects, and increasing compliance. Disadvantages include skin irritation skin irritation,
n reaction to a particular irritant that results in inflammation of the skin and itchiness.
 and the fact that sweating can cause the patch to fall off (Popper, 1997).

Medication Summary

Popper (1997) concludes his summary of medication use by suggesting that stimulants are the drug of choice for ADHD treatment because they improve cognition. In contrast, although TCAs treat hyperactivity and impulsivity, they do not improve cognition. Avoid Desipramine altogether because other TCAs are safer. Bupropion may be comparable to stimulants, but tics and skin rash limit its usefulness. TCAs and bupropion may be preferred over stimulants for those who abuse drugs or who live with someone abusing drugs. Bupropion and stimulants would be more likely to aggravate tics in people with co-morbid ADHD and Tourette's disorder than would TCAs. For those with ADHD and seizure disorders, stimulants may be better than TCAs or bupropion.

Popper (1997) suggests that it would make sense for future medications to last longer than 6 hours to help eliminate midday dosing, to reduce daily on-off effects, and to reduce rebound. We must focus on medications that improve attention and cognition as well as motivation and organization, if we are to assist children with ADHD.

COMBINATION/MULTIMODAL TREATMENTS

Reasons for Multiple Treatments

No single medical or psychosocial intervention can treat ADHD (Erk, 1995). No single intervention will provide long-term benefit to ADHD children who have different levels of co-morbidity, family backgrounds, and functional deficits (Richters et al., 1995). So, combining drugs with multimodal psychosocial interventions is of great interest (Richters, 1995). As yet, little is known about the effects of combining medications for treating ADHD symptoms and so guidelines are limited (Spencer et al., 1996; Biederman, 1998).

Although adequate trials have not been completed, medications are beginning to be combined to treat resistant ADHD (Popper, 1997). Historically, stimulants and antipsychotics Antipsychotics
A class of drugs used to control psychotic symptoms in patients with psychotic disorders such as schizophrenia and delusional disorder. Antipsychotics include risperidone (Risperdal), haloperidol (Haldol), and chlorpromazine (Thorazine).
 were combined, and two studies have combined a neuroleptic neuroleptic /neu·ro·lep·tic/ (-lep´tik) originally, referring to the effects on cognition and behavior of the first antipsychotic agents: a state of apathy, lack of initiative, and limited range of emotion, and in psychotic patients,  and a stimulant with better results than either used alone (Spencer et al., 1996). Findings suggest that combining the neuroleptics Neuroleptics
Any of a class of drugs used to treat psychotic conditions.

Mentioned in: Stuttering, Tardive Dyskinesia
 haloperidol haloperidol /hal·o·peri·dol/ (hal?o-per´i-dol) an antipsychotic agent of the butyrophenone group with antiemetic, hypotensive, and hypothermic actions; used especially in the management of psychoses and to control vocal utterances and  or orpimozide with stimulants may help those who have tics or Tourette's syndrome (Cantwell, 1996). Also, Spencer et al. (1996) measured the separate and combined effects of Ritalin and desipramine. Results suggest that Ritalin alone improved alertness, both alone helped short-term memory short-term memory
n.
Abbr. STM The phase of the memory process in which stimuli that have been recognized and registered are stored briefly.
 and visual problem solving problem solving

Process involved in finding a solution to a problem. Many animals routinely solve problems of locomotion, food finding, and shelter through trial and error.
, and together they improved learning (Spencer et al., 1996). One study using Ritalin and desipramine for ADHD and a mood disorder mood disorder 
n.
Any of a group of psychiatric disorders, including depression and bipolar disorder, characterized by a pervasive disturbance of mood that is not caused by an organic abnormality. Also called affective disorder.
 yielded no side effects and a better outcome than when used alone. Another study using Ritalin and desipramine reported more side effects than when either was used alone, but with effects that were no more serious than when desipramine was used alone (Dulcan, Dunne, et al., 1997). Antidepressants and stimulants have been combined for ADHD and co-morbid depression, and lithium has been used with an anti-ADHD drug to control ADHD co-morbid with bipolar disorder bipolar disorder, formerly manic-depressive disorder or manic-depression, severe mental disorder involving manic episodes that are usually accompanied by episodes of depression.  (Spencer et al., 1996).

Imipramine and Ritalin were used safely in some situations but in others confusion, aggression, and agitation resulted (Dulcan, Dunne, et al., 1997). To improve behavior and attention, Clonidine and Ritalin are often used in combination (Popper, 1997). Note, however, that three sudden deaths occurred with this same combination and that an alternative is to switch Dexedrine with Ritalin and guanfacine (another alpha 2 agonist) with clonidine (Dulcan, Dunne, et al., 1997). When dealing with drug combinations, the major risk is cardiovascular failure, but this risk is lowered when doses are gradually titrated ti·trate  
tr. & intr.v. ti·trat·ed, ti·trat·ing, ti·trates
To determine the concentration of (a solution) by titration or perform the operation of titration.
 and closely monitored (Popper, 1997).

Multimodal Approach

Although combining medications is an effective method with ADHD youth, some research indicates that a combined psychosocial and medical intervention is superior (Cantwell, 1996). Other research suggests that although people believe that a multimodal treatment approach is superior to either medication or psychosocial interventions used alone, evidence for multimodal treatment is meager mea·ger also mea·gre  
adj.
1. Deficient in quantity, fullness, or extent; scanty.

2. Deficient in richness, fertility, or vigor; feeble: the meager soil of an eroded plain.

3.
 because of the cost of conducting trials, complexity of studies, length of time required for such trials, or the large number of participants needed (Dulcan, Dunne, et al., 1997). Nevertheless, one advantage of a multimodal approach is that coping skills learned with the psychosocial intervention would remain when the effects of the medication begin to wear off. In addition, ADHD youth who have better coping skills may require a lower dosage of medicine. Short-term studies indicate that medication alone, or psychosocial interventions alone, are not enough to allow youth to control behaviors enough to do well academically (Dulcan, Dunne, et al., 1997). Studies also indicate that behavior modification behavior modification
n.
1. The use of basic learning techniques, such as conditioning, biofeedback, reinforcement, or aversion therapy, to teach simple skills or alter undesirable behavior.

2. See behavior therapy.
, when used alone, is less effective than when medication is used alone, and they also indicate that a multimodal approach is needed for ADHD youth with co-morbid disorders (Popper, 1997).

Dulcan, Dunne, et al. (1997) describe a multimodal treatment plan in which, 3 years after the initial study, participants who received medication along with psychosocial interventions improved their home and school behavior and their academic performance and decreased their delinquent behavior. Some successful multimodal programs include summer treatment programs; other successful multimodal programs use stimulants and enlist strong parent involvement so that the social skills component was reinforced and generalized to other settings (Frankel, Myatt, Cantwell, & Feinberg, 1997). One specific multimodal approach that includes parent involvement is the Irvine Paraprofessional paraprofessional

1. a person who is specially trained in a particular field or occupation to assist a veterinarian.

2. allied animal health professional.

3. pertaining to a paraprofessional.
 Program. In this program, children with severe ADHD symptoms are placed in a regular school classroom for 12 weeks to learn behavioral modification, skill training, and pharmacological assessment (Kotkin, 1998). Taken together, these research results indicate that combining interventions works when treating co-morbidity, when youth do not respond to a single intervention, and when side effects need to be reduced (Biederman, 1998). Regardless of the intervention ultimately used, individual assessment is a necessity.

Combining medications and using multimodal interventions are complicated processes where little is known and more research is needed before combination approaches are fully understood (Richters et al, 1995). The central question is this: Under what circumstances (co-morbid conditions, age, gender, family background) do which treatment combinations (medication, behavior therapy behavior therapy or behavior modification, in psychology, treatment of human behavioral disorders through the reinforcement of acceptable behavior and suppression of undesirable behavior. , parent training, school-based intervention) have what impact (improvement, stasis stasis /sta·sis/ (sta´sis)
1. a stoppage or diminution of flow, as of blood or other body fluid.

2. a state of equilibrium among opposing forces.
, deterioration) on what domains of child functioning (cognitive, academic, behavioral, physical, peer relations, family relations) for how long (short- versus long- term), to what extent (effect sizes, normal versus pathological range), and why (processes underlying change)?

CONCLUSION

Although most mental health and school counselors know about the use of Ritalin, and although most know that medicines are used to reduce the symptoms associated with ADHD, many counselors do not know enough about this topic to be able to determine for themselves whether they believe that medication only, psychosocial intervention only, or both medication and psychosocial intervention ought to be used in treating ADHD in children and adolescents. We hope this article helps to clarify some of the key aspects of this controversial topic. In fact, we remain skeptical regarding the use of medical intervention given the serious known and unknown side effects. Nevertheless, medications are commonly prescribed, and mental health counselors are increasingly forming partnerships with school counselors to help ADHD youth. Counselors must be continuously informed on this topic so that they can at least know their own opinions when a parent, teacher, principal, or child asks for help in managing ADHD symptoms.

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A condition in which a person (usually a child) has an unusually high activity level and a short attention span. People with the disorder may act impulsively and may have learning and behavioral problems.
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An important antecedent to the specialty of child psychiatry was the social recognition of childhood as a special phase of life with its own developmental stages, starting with
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Erk, R. R. (1995). A diagnosis of attention deficit disorder: What does it mean for school counselors and mental health counselors. The School Counselor, 42, 292-299.

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James, S. H., & Nims, D. R. (1996). A catalog of psychiatric medications This is an alphabetical list of psychiatric medications used by psychiatrists to treat mental illness or distress.

Please note:
  • The list is not exhaustive.
  • Names in italics are brand-names.
  • Not all drugs listed are used regularly in all countries.
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adj.
1. Being other than verbal; not involving words: nonverbal communication.

2. Involving little use of language: a nonverbal intelligence test.
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Richters, J. E., Arnold, L. E., Jensen, P. S., Abikoff, H., Conners, C. K., Greenhill, L. L., Hechtman, L., Hinshaw, S. P., Pelham, W. E., & Swanson, J. M. (1995). NIMH collaborative multimodal treatment study of children with ADHD: I. Background and rationale. Journal of American Academy of Child and Adolescent Psychiatry, 34, 987-1000.

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Spencer, T., Biederman, J. & Wilens, T., Harding, M., O'Donnell, D., & Griffin, S. (1996). Pharmacotherapy pharmacotherapy /phar·ma·co·ther·a·py/ (-ther´ah-pe) treatment of disease with medicines.

phar·ma·co·ther·a·py
n.
Treatment of disease through the use of drugs.
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Spencer, T., Biederman, J., Wilens, T., Steingard, R., & Geist, D. (1993). Nortriptyline treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. Journal of American Academy of Child and Adolescent Psychiatry, 32, 205-210. Swanson, J. M., Wigal, S., Greenhill, L. L., Browne, R., Waslik, B., Lemer, M., Williams, L., Flynn,

D., Agler, D., Crowley, K., Fineberg, E., Baren, M., & Cantwell, D. P. (1998). Analog classroom assessment of adderall in children with ADHD. Journal of American Academy of Child and Adolescent Psychiatry, 37, 519-526.

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Alex S. Hall, Ph.D., is an assistant professor, Division of Counseling Rehabilitation rehabilitation: see physical therapy.  and Student Development, The University of Iowa Not to be confused with Iowa State University.
The first faculty offered instruction at the University in March 1855 to students in the Old Mechanics Building, situated where Seashore Hall is now. In September 1855, the student body numbered 124, of which, 41 were women.
, Iowa City Iowa City, city (1990 pop. 59,738), seat of Johnson co., E Iowa, on both sides of the Iowa River; founded 1839 as the capital of Iowa Territory, inc. 1853. Among its manufactures are foam rubber, animal feed, paper, and food products. The city is the seat of the Univ. . Email alex-hall@uiowa.edu Arlinn G. Gushee, is a teacher at Urbandale Middle School, Urbandale, IA.
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Title Annotation:Counseling Adolescents
Author:Gushee, Arlinn G.
Publication:Journal of Mental Health Counseling
Geographic Code:1U4IA
Date:Apr 1, 2002
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