Measurement of environmental tobacco smoke exposure among adults with asthma. (Articles).

Because the morbidity and mortality from adult asthma have been increasing, the identification of modifiable environmental exposures that exacerbate asthma has become a priority. Limited evidence suggests that exposure to environmental tobacco smoke (ETS) may adversely affect adults with asthma. To study the effects of ETS better, we developed a survey instrument to measure ETS exposure in a cohort of adults with asthma living in northern California, where public indoor smoking is limited. To validate this survey instrument, we used a passive badge monitor that measures actual exposure to ambient nicotine, a direct and specific measure of ETS. In this validation study, we recruited 50 subjects from an ongoing longitudinal asthma cohort study who had a positive screening question for ETS exposure or potential exposure. Each subject wore a passive nicotine badge monitor for 7 days. After the personal monitoring period, we readministered the ETS exposure survey instrument. Based on the survey, self-reported total ETS exposure duration ranged from 0 to 70 hr during the previous 7 days. Based on the upper-range boundary, bars or nightclubs (55 hr) and the home (50 hr) were the sites associated with greatest maximal self-reported exposure. As measured by the personal nicotine badge monitors, the overall median 7-day nicotine concentration was 0.03 [micro]g/[m.sup.3] (25th-75th interquartile range 0-3.69 [micro]g/[m.sup.3]). Measured nicotine concentrations were highest among persons who reported home exposure (median 0.61 [micro]g/[m.sup.3]), followed by work exposure (0.03 [micro]g/[m.sup.3]), other (outdoor) exposure (0.025 [micro]g/[m.sup.3]), and no exposure (0 [micro]g/[m.sup.3]; p = 0.03). The Spearman rank correlation coefficient between self-reported ETS exposure duration and directly measured personal nicotine concentration during the same 7-day period was 0.47, supporting the survey's validity (p = 0.0006). Compared to persons with no measured exposure, lower-level [odds ratio (OR) 1.9; 95% confidence interval (CI), 0.4-8.8] and higher-level ETS exposures (OR 6.8; 95% CI, 1.4-32.3) were associated with increased risk of respiratory symptoms. A brief, validated survey instrument can be used to assess ETS exposure among adults with asthma, even with low levels of exposure. This instrument could be a valuable tool for studying the effect of ETS exposure on adult asthma health outcomes. Key words: asthma, biological markers, environmental monitoring, nicotine, smoking, tobacco smoke pollution.

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During the past decade, the morbidity and mortality from adult asthma have been increasing. Consequently, identifying modifiable environmental factors that exacerbate asthma has become a priority. Limited evidence indicates that exposure to environmental tobacco smoke (ETS) may exacerbate asthma among adults (1-4). Further research is necessary to establish the causal connection between ETS exposure and adverse asthma health outcomes in adults. To elucidate the effects of ETS better, we developed a survey instrument to measure ETS exposure in a cohort of adults with asthma living in northern California.

Previous questionnaires have been designed to assess ETS exposure, but they have limitations for studying the effect of ETS exposure on asthma health status in adults. The validation of most previous ETS questionnaire instruments occurred in places and times at which cigarette smoking was more common. Consequently, their utility in California, where the prevalence of smoking currently is substantially lower than in most other states, is unclear (5). Since most previous ETS survey instruments have been published, California state law has prohibited smoking in nearly all workplaces effective 1 January 1995 (6). This change may have affected the locations of ETS exposure, including a shift in indoor workplace exposure to outdoor locations. Moreover, previous instruments have not ascertained asthma-related ETS effects, such as respiratory symptoms and medication use. To study the effects of ETS on adults with asthma living in northern California, we developed a survey instrument that measures exposure in relevant microenvironments, including outdoor workplaces.

Another limitation of previous studies is validation using serum, urine, or salivary cotinine, a nicotine metabolite and biomarker of ETS exposure (7-16). Because it has substantial person-to-person variability due to uptake, metabolism, and elimination, cotinine has limitations as a biomarker of ETS exposure (17). Cotinine is also found in several foods, reducing its specificity for ETS when exposure levels are very low (17,18). The half-life of cotinine is relatively short (1-2 days), which limits its utility for assessing exposure during a longer period. To validate the ETS exposure survey instrument, we used a passive badge monitor that measures actual exposure to ambient nicotine, a more direct and specific measure of personal ETS exposure (19,20).

Materials and Methods

Overview. We developed a survey instrument to measure ETS exposure among adults with asthma living in northern California. To validate the instrument, we recruited 50 subjects from an ongoing longitudinal asthma cohort study who had a positive screening question for ETS exposure or potential exposure. Each subject wore a passive nicotine badge monitor for 7 days. After the personal monitoring period, we read-ministered the ETS exposure survey instrument. The study was approved by the University of California San Francisco Committee on Human Research.

Subject recruitment. We used data collected during an ongoing prospective, longitudinal cohort study of adults with asthma recruited from physician practices in northern California. Details of recruitment have been reported previously (21-23). In brief, we initially recruited subjects from a random sample of board-certified internal medicine and pulmonary specialists, internal medicine and allergy/immunology specialists, and family practice specialists. The present study eligibility is based on follow-up interviews conducted between July 1998 and December 1999, which included 402 subjects.

We included the newly developed ETS exposure survey instrument in structured telephone interviews. Subjects with no current personal tobacco smoking and a positive answer to any screening question indicating potential ETS exposure were eligible for the validation study (n = 235). The screening questions assessed residence with a smoker and ETS exposure during the previous 7 days at home, another person's home, work, car or other vehicle, bars and nightclubs, and other locations. We enrolled 50 sequential subjects who agreed to participate in the validation study, which included wearing the personal nicotine badge monitor for 7 days and then completing a second telephone administration of the ETS survey instrument. Structured telephone interview content also included demographic characteristics, asthma history, asthma-specific severity and quality of life (24-26), environmental exposures, health status (SF-12) (27), and health care utilization for asthma.

As shown in Table 1, there were no statistical differences in demographic characteristics or smoking status between participants (n = 50) and nonparticipants (n = 185) who had indicated potential ETS exposure at the initial interview. Compared to nonparticipants, participants had somewhat worse SF12 physical component summary scores (41.7 vs. 46.5, p = 0.007) and severity-of-asthma scores (10.7 vs. 9.2, p = 0.09). Conversely, SF-12 mental component summary scores were slightly better among participants (47.2 vs. 44.6, p = 0.04). There were no statistical differences in asthma-specific quality-of-life scores. At the initial interview, self-reported duration of ETS exposure during the previous 7 days was similar for participants and nonparticipants (p = 0.33). Because of study logistics, the median interval between initial interview and subsequent validation interview was 225 days (25th-75th interquartile range 138-311 days).

ETS exposure survey instrument. We designed a survey instrument to measure recent ETS exposure among adults with asthma living in northern California (survey included in Appendix). The instrument assesses exposure during the previous 7 days in six microenvironments: the respondent's home, another person's home, traveling in a car or another vehicle, workplace, bars and nightclubs, and other locations. For home exposure, the survey assesses both residence with a smoker and duration of exposure during the previous 7 days (in hours). For each microenvironment, a screening question elicits exposure during the previous 7 days. If there was no exposure, the remaining location-specific items are skipped. Given the workplace smoking restrictions in California, the instrument specifically ascertains exposure in the most likely work-related locations: outdoor smoking areas at work and outdoor job duties. In each area, the instrument ascertains the total duration (in hours) of exposure during the previous 7 days and the intensity of exposure, as indicated by the presence of tobacco smoke odor or visible smoke. In each location, we also assessed exposure-related sensory irritation symptoms (eye and nose irritation) and potential asthma-related respiratory symptoms (coughing, wheezing, or chest tightness). Furthermore, the instrument ascertains whether the subject used extra metered-dose inhaler asthma medications after ETS exposure during the same period.

Personal nicotine badge monitors. Each subject was instructed to wear the personal nicotine badge monitor during regular activities for 7 days. The passive monitor, which has been described previously (19,20), samples nicotine from ambient air. A 4-cm diameter polystyrene cassette holds a filter treated with sodium bisulfate and a membrane filter functions as a windscreen. Ambient nicotine diffuses to the treated filter, where it is trapped. The collected nicotine is analyzed by gas chromotography with nitrogen selective detection. From the amount of nicotine measured on the filter (micrograms), which represents the total amount of nicotine collected during the monitoring period, we calculated the nicotine concentrations by dividing the nicotine collected by the estimated volume of air sampled (monitoring duration multiplied by sampling rate of 24 mL/min). The passive monitors have a limit of detection < 0.01 lag per filter and a coefficient of variability of 0.11 for replicate analysis (20). We included two control badges (field blanks), which revealed no detectable nicotine.

Statistical analysis. We analyzed the data using SAS version 6.12 (SAS Institute, Cary, NC). We performed bivariate analysis using the chi-square test for categorical variables, t-test for continuous normally distributed variables, and Wilcoxon rank-sum test for non-normally distributed, continuous variables. Because self-reported duration of ETS exposure and measured nicotine concentration were non-normally distributed, we report the median values, range, and interquartile range.

To validate the ETS exposure instrument, we calculated the Spearman rank correlation between total self-reported hours of exposure in all locations with the nicotine concentration measured by personal badge monitoring. In addition to this primary analysis, we tested two alternative scoring systems defined a priori. First, we calculated an ETS exposure score weighted for exposure intensity. For each location of exposure, we weighted exposure duration by 130% for reported tobacco smoke odor and 150% for visible smoke. Second, we calculated an ETS exposure score weighted for sensory irritation and respiratory symptoms (1 point added for each symptom).

To evaluate exposure stability over time, we compared the self-reported duration of ETS exposure during the previous 7 days at the initial and validation telephone interviews. Because duration of exposure was not normally distributed, we performed a rank transformation and then used analysis of variance to calculate the intraclass correlation.

To validate the questions assessing self-reported ETS-attributed symptoms and extra asthma medication use, we used logistic regression analysis to examine the cross-sectional relation between personal nicotine exposure and the risk of sensory irritation symptoms, respiratory symptoms, and extra inhaled asthma medication use. We created indicator variables to reflect lower and higher levels of exposure, which we divided at the median nicotine concentration for subjects with measurable exposure. We tested linear exposure-response relationships by creating an ordinal predictor variable coding the three nicotine concentration categories (none, lower, and higher). We also tested quadratic exposure-response relationships.

Results

ETS exposure and measured nicotine concentration. At the initial interview, 45 of 50 participants reported at least 1 hr of ETS exposure during the previous 7 days, and five additional subjects indicated potential ETS exposure, indicated by residence with a smoker. At the validation interview performed at completion of personal nicotine monitoring, most subjects who initially reported exposure or potential exposure indicated a least 1 hr of ETS exposure (38 of 50, 76%; Table 2). A greater proportion of subjects who reported > 1 hr of ETS exposure at initial interview reported recent exposure at validation interview (37 of 45, 82%).

Of subjects reporting exposure at validation interview, the proportion with indoor exposure and outdoor exposure were comparable (53% and 47%). Of the 20 subjects with indoor exposure, 12 persons also indicated outdoor exposure (60%). The workplace was the major site of exposure (38%), followed by "other" locations, which were all outdoors, and home (14%). All subjects with workplace exposure reported recent exposure in an outdoor smoking area at work, whereas only one subject also reported outdoor exposure during work duties. Only a minority of subjects who lived with a smoker reported any domestic ETS exposure during the previous 7 days (6 of 17 persons, 35%). Conversely, nearly all subjects who had no smoking cohabitants indicated no recent home ETS exposure (32 of 33 persons, 97%).

Table 3 shows the proportion of subjects exposed in each of six microenvironments evaluated by the questionnaire instrument and self-reported exposure duration. Exposure duration ranged from 0 to 70 hr during the previous 7 days. Based on the upper range boundary, bars or nightclubs (55 hr) and the home (50 hr) were the sites associated with greatest maximal self-reported exposure in the previous 7 days.

As measured by the personal nicotine badge monitors, the overall median 7-day nicotine concentration was 0.03 [micro]g/[m.sup.3] (25th-75th interquartile range 0-3.69 [micro]g/[m.sup.3]; Table 4). The measured nicotine concentration varied significantly by self-reported exposure location. Compared with subjects indicating no ETS exposure (median 0 [micro]g/[m.sup.3]), persons with outdoor exposure (median 0.03 [micro]g/[m.sup.3]) and indoor exposure (0.05 [micro]g/[m.sup.3]) had progressively higher levels (p = 0.03; Table 4). Of note, more than half of subjects who reported outdoor exposure only had detectable nicotine levels. Measured nicotine concentrations were highest among persons who reported home exposure (median 0.61 [micro]g/[m.sup.3]), followed by work exposure (0.03 [micro]g/[m.sup.3]), other (outdoor) exposure (0.025 [micro]g/[m.sup.3]), and no exposure (0 [micro]g/[m.sup.3]; p = 0.03).

Survey instrument validity. To assess validity, we compared the measurements of ETS exposure based on the survey instrument and the passive badge monitors (Table 5). The Spearman rank correlation coefficient between self-reported ETS exposure duration and directly measured personal nicotine concentration during the same 7day period was 0.47, indicating moderate agreement (p = 0.0006). The exposure scores adjusting for exposure intensity and exposure intensity plus sensory irritation and respiratory symptoms did not improve the correlation (Table 5). Excluding subjects with no measurable nicotine concentration did not affect these results appreciably. To examine the stability of recent ETS exposure over time, we compared the self-reported total hours of ETS exposure ascertained during the validation interview with the initial interview. The intraclass correlation was 0.72, indicating moderate to high stability over time.

ETS exposure and the risk of symptoms. To evaluate the validity of self-reported ETS-attributed symptoms, we examined the cross-sectional relation between directly measured personal nicotine concentration and the risk of sensory irritation symptoms, respiratory symptoms, and medication use. Compared to persons with no measured exposure, lower-level and higher-level ETS exposures were associated with increased risk of sensory symptoms, including eye, nose, and throat irritation [odds ratio (OR) 2.2 and 5.9, respectively; Table 6]. Lower- and higher-level ETS exposures also were related to an increased risk of respiratory symptoms (OR 1.9 and 6.8) and extra bronchodilator use after ETS exposure (OR 2.2 and 8.1). For all three outcomes, there was statistical evidence of a simple exposure-response relation (p = 0.054, 0.017, and 0.022, respectively). There was no evidence of a quadratic exposure-response relation (p > 0.5 in all cases).

Discussion

We developed an ETS exposure instrument that is brief and easy to administer by telephone interview. The ETS questionnaire can be incorporated easily into a larger survey instrument. Self-reported total hours of ETS exposure during the previous 7 days correlated moderately with measured nicotine concentration, supporting the instrument's validity. More complex scoring systems that incorporate intensity of exposure or intensity plus respiratory and sensory irritation symptoms do not appreciably improve instrument validity. Exposure monitoring also supported the validity of self-reported ETS-attributed symptoms and medication use. ETS exposure, measured by the personal nicotine badge, was associated with a greater risk of ETS-attributed sensory irritation symptoms, respiratory symptoms, and extra medication use.

We found a moderate correlation between self-reported ETS exposure duration and direct personal nicotine measurements, consistent with previous studies that used cotinine as a biomarker (7-16). Fewer studies have used personal nicotine monitoring, which measures actual exposure, to validate questionnaire instruments. In a study of 415 pregnant women, O'Connor and colleagues (28) demonstrated a similar correlation between total duration of ETS exposure and nicotine concentration (r = 0.41). The investigators cautioned that their results should not be extrapolated to nonpregnant women, who may have different patterns of exposure. Other investigators used a more complicated questionnaire instrument that assessed duration, intensity, and proximity of each individual ETS exposure during the previous week (29). Using personal nicotine monitoring, they found a higher correlation with an index of ETS exposure based on these variables (r = 0.91). This questionnaire requires subject response entry in multicell tables that would be difficult to administer by telephone.

For most subjects, the observed nicotine concentrations were low, with a median of 0.03 [micro]g/[m.sup.3] (range 0-3.69 [micro]g/[m.sup.3]). Compared to our study, Coghlin and colleagues (29) found higher nicotine concentrations among 53 volunteers who wore personal monitors during a typical week (median 1.7 [micro]g/[m.sup.3] and 2.8 [micro]g/[m.sup.3] in two different periods) (29). The observed concentrations among 50 adults with asthma were more comparable to those of pregnant women who reported ETS exposure (median 0.1 [micro]g/[m.sup.3]). Pregnant women who reported only social exposure had even lower concentrations (median 0.08 [micro]g/[m.sup.3]). Both pregnant women and adults with asthma, because of their health conditions, might be expected to limit their ETS exposure.

Adults with asthma living in northern California had low levels of ETS exposure, reflecting the restrictions on public smoking. Moreover, the locations where ETS exposure occurs appear to be changing. Residence with a smoker, which has been used in many epidemiologic studies as a key marker of ETS exposure (30-32), was a poor indicator of recent exposure. Only a minority of adults with asthma who live with a smoker reported any exposure during the previous 7 days, most likely because smoking was not permitted indoors. A shift from indoor to outdoor exposure was also observed, with 38% of subjects indicating outdoor workplace exposure. Future ETS exposure survey instrument should take these temporal trends into account.

This validation study is potentially limited by the low observed exposure levels, which may have attenuated the correlation between self-reported exposure and nicotine concentration. However, these low exposure levels reflect current restrictions in public smoking that require consideration in epidemiologic studies. Even among persons who may have lower than average ETS exposure due to their disease, the instrument appears to have adequate validity. The ETS exposure survey instrument also measures a 7-day period, which may not be fully representative of a subject's usual exposure. Furthermore, our instrument, which is adapted for use in California, does not assess indoor workplace exposure. A section for indoor work exposure can be easily added, modeled on those developed for other microenvironments (available from the authors). Further research will be necessary to evaluate the survey in other environmental-settings, such as large industrial workplaces, where building ventilation may be different. In such settings, tailor-made survey instruments could be required.

Validation of the ETS exposure survey instrument was also limited by measurement of a single marker of ETS exposure. Because ETS contains more than 4,000 chemical compounds, it is not feasible to measure all ETS constituents (32,33). Although nicotine is a highly specific marker of ETS, it may not always track with the ETS components responsible for disease causation or exacerbation. In particular, the relationship between nicotine concentration and other ETS constituents may be affected by factors such as building ventilation rate and indoor air volume (17,33). In addition, nicotine may adsorb to indoor surfaces and be reemitted in the absence of active smoking, changing its concentration relative to other ETS constituents (17). Despite these factors, field studies indicate that nicotine correlates strongly with other ETS constituents, including respiratory suspended particles (34,35) and 3-ethenylpyridine (a volatile organic compound unique to ETS) (34).

Most epidemologic studies of ETS-related health effects have used self-reported ETS exposure. All survey-based methods of ascertaining ETS exposure are potentially limited by information bias (i.e., misclassification of exposure). For example, persons with symptomatic respiratory disease may be more likely to remember and report recent ETS exposure. In our study of adults with asthma, personal nicotine badge monitoring was a feasible method for directly measuring ETS exposure, potentially minimizing this information bias.

A brief survey instrument can be used to assess ETS exposure among adults with asthma, even with low levels of exposure. The instrument is valid and can be incorporated into larger telephone-based interviews. This instrument could be a valuable tool for studying the effect of ETS exposure on adult asthma health outcomes.

Appendix

Environmental Tobacco Smoke Questionnaire Instrument

The next series of questions ask about your exposure to other people's
tobacco smoke.

Q1. Many people have different approaches to tobacco smoking in their
household. Which is the best description of tobacco smoking in your
home? Would you say that:
    (1) You never allow smoking inside your home,
    (2) Smoking is allowed only in certain rooms, but not in other
    areas of your living space, or
    (3) Smoking is allowed in all rooms of your home.

Q2. Do you live in the same household with someone who smokes tobacco
products?
   [if yes to Q2] Q3. How many people in your household smoke?
   [If Q1 = 2 or 3 and Q2 = yes] Q4. Has anyone smoked tobacco in
   your home in the past seven days?
        [If yes to Q4, then ask next series; else skip to Q12]
        Q5. In the past 7 days, how many hours in total were you
        exposed to someone else's tobacco smoke at home?
        Q6. During the past 7 days, did you enter a room in your home
        that was visibly smoky?
        Q7. In the past 7 days, did you smell tobacco smoke in your
        home?
        You said that you were exposed to someone else's tobacco
        smoke in your home. During the past 7 days, did you
        experience any of the following after this exposure:
             Q8. Red eyes or eye irritation?
             Q9. Runny nose or nose irritation?
             Q10. Coughing, wheezing, or chest tightness?
             Q11. In the past 7 days, did you take extra asthma
             sprays after exposure to tobacco smoke in your home?

Q12. In the past 7 days, have you visited another person's home where
someone was smoking tobacco products indoors?
   [If yes to Q12 then ask next series; else skip to Q20]
   Q13. In the past 7 days, how many hours in total were you exposed
   to someone else's tobacco smoke in another person's home?
   Q14. During the past 7 days, did you enter a room in another
   person's home that was visibly smoky?
   Q15. In the past 7 days, did you smell tobacco smoke in another
   person's home?
   You answered that you were exposed to someone else's tobacco smoke
   in another person's home. During the past 7 days, did you experience
   any of the following after this exposure:
        Q16. Red eyes or eye irritation?
        Q17. Runny nose or nose irritation?
        Q18. Coughing, wheezing, or chest tightness?
   Q19. In the past 7 days, did you take extra asthma sprays after
   exposure to tobacco smoke in another person's home?

Q20. In the past 7 days, have you traveled by car or other vehicle
with someone else who was smoking tobacco products?
   [If yes to Q20 then ask next series; else skip to Q26]
   Q21. In the past 7 days, how many hours in total did you spend
   traveling in a car while someone was smoking tobacco?
   You answered that you were exposed to someone else's tobacco smoke
   while traveling by car. During the past 7 days, did you experience
   any of the following after this exposure:
        Q22. Red eyes or eye irritation?
        Q23. Runny nose or nose irritation?
        Q24. Coughing, wheezing, or chest tightness?
   Q25. In the past 7 days, did you take extra asthma sprays after
   exposure to someone else's tobacco smoke in a car?

Q26. Is there an outdoor area at your workplace where cigarette
smokers routinely gather or congregate in order to smoke?
   [If yes to Q26 then ask next series; else skip to Q33]
   Q27. In the past 7 days, how many times did you walk through or
   past this area while others were smoking?
   Q28. While walking through or past this area, did you smell smoke?
   In the past 7 days, did walking through or past this area result in
   your experiencing any of the following:
        Q29. Red eyes or eye irritation?
        Q30. Runny nose or nose irritation?
        Q31. Coughing, wheezing, or chest tightness?
   Q32. In the past 7 days, did you take extra asthma sprays after
   walking through or past this area?
   Q33. Do your job duties directly involve working outdoors one or
   more hours per week?
   [If yes to Q33] Q34. During your work outdoors, do any of your
   coworkers smoke tobacco products in your presence?
   [If] yes to Q34 then ask next series; else skip to Q42]
   Q35. In the past 7 days, how many hours did you spend near
   coworkers who were smoking tobacco outdoors?
   Q36. During the past 7 days, did you smell tobacco smoke while
   working outdoors?
   You answered that you were exposed to your coworkers' tobacco
   smoke while working outdoors. During the past 7 days, did you
   experience any of the following after this exposure:
        Q37. Red eyes or eye irritation?
        Q38. Runny nose or nose irritation?
        Q39. Coughing, wheezing, or chest tightness?
   Q40. In the past 7 days, did you take extra asthma sprays after
   exposure to tobacco smoke outdoors?
   Q41. In the past 7 days, did you take extra asthma sprays after
   working outdoors WITHOUT tobacco smoke exposure?

Q42. In the past 7 days or nights, were you in a bar, nightclub,
cocktail lounge, sports arena, or concert hall where someone else was
smoking tobacco products?
   [If yes to 042 then ask next series; else skip to Q50]
   Q43. In the past 7 days, how many hours in total were you exposed
   to someone else's tobacco smoke in a bar or other place of
   entertainment?
   Q44. During the past 7 days, did you enter a room in a bar or
   other place of entertainment that was visibly smoky?
   Q45. In the past 7 days did your clothes smell like tobacco smoke
   after returning home from a bar or other place of entertainment?
   You answered that you were exposed to someone else's tobacco smoke
   in a bar or other place of entertainment.
   During the past 7 days, did you experience any of the following
   after this exposure:
       Q46. Red eyes or eye irritation?
       Q47. Runny nose or nose irritation?
       Q48. Coughing, wheezing, or chest tightness?
   Q49. In the past 7 days, did you take extra asthma sprays after
   exposure to tobacco smoke in a bar or other place of entertainment?

Q50. I have asked you about exposure to someone else's tobacco smoke
in your home, friends' homes, work, and bars or nightclubs. In the
past 7 days, was there any other location where you were exposed to
tobacco smoke?
   [If yes to Q51 then ask next series; else skip to end]
   Q51. Specify: --
   During the past 7 days, did you experience any of the following
   after this exposure:
       Q52. Red eyes or eye irritation?
       Q53. Runny nose or nose irritation?
       Q54. Coughing, wheezing, or chest tightness?
   Q55. Did you use extra asthma sprays after exposure to someone
   else's tobacco smoke in this place?

Administration and Scoring

Unless otherwise specified, all questions have yes/no response
options. For each microenvironment, a screening question (in bold
font) ascertains whether any ETS exposure occurred during the past 7
days. If the subject indicates ETS exposure in that environment, then
a series of questions assess duration of exposure, exposure intensity,
and symptoms/asthma medication use. Otherwise, the survey skips to the
next microenvironment screening question.

To determine the total duration of exposure during the past 7 days,
sum the individual microenvironment exposure durations (Q5 + Q13 +
Q21 + Q35 + Q43). An ETS exposure score weighted for exposure
intensity can also be calculated. For each location of exposure, we
weighted exposure duration by 130% for reported tobacco smoke odor
and 150% for visible smoke. A second ETS exposure score weighted for
sensory irritation and respiratory symptoms is calculated by further
adding 1 point added for each symptom.
Table 1. Baseline characteristics of subjects participating in
personal nicotine badge monitor study compared with other subjects
from the asthma cohort.

                                         Subject group

                                                    ETS exposure,
                                 No ETS exposure   nonparticipant
Variable                            (n = 167)       (n = 185) (a)

Demographic characteristics
 Age (mean years, SD)              45.0 (7.4)        43.1 (7.8)
 Sex (% female)                     121 (72)          128 (69)
 Race/ethnicity (% white,
  non-Hispanic)                     133 (80)          120 (65)
 Income (median $, 25th-75th         62,500            45,000
  IQR)                           (35,000-87,500)   (35,000-87,500)
 Ever smoked cigarettes (%)          70 (42)           63 (34)
 Currently smoke cigarettes
  (%)                                27 (16)              0
Asthma severity/health status
 Severity-of-asthma score           9.2 (5.3)         9.2 (5.1)
 Asthma quality-of-life score      15.3 (14.9)       16.3 (13.8)
 SF-36 physical summary score      45.8 (12.1)       46.5 (102)
 SF-36 mental summary score        45.4 (7.7)        44.6 (8.3)
ETS exposure
 Duration of exposure, past 7
  days (median, 25th-75th IQR)
  (b)                                0 (0-0)           0 (0-1)

                                  Subject group

                                  ETS exposure,      p-Value for
                                     badge           participant
                                   participant          vs.
Variable                            (n = 50)       nonparticipant

Demographic characteristics
 Age (mean years, SD)              44.4 (7.9)           0.30
 Sex (% female)                      36 (72)            0.70
 Race/ethnicity (% white,
  non-Hispanic)                      36 (72)            0.34
 Income (median $, 25th-75th         62,500
  IQR)                           (31,250-87,500)        0.95
 Ever smoked cigarettes (%)          15 (30)            0.59
 Currently smoke cigarettes
  (%)                                   0                --
Asthma severity/health status
 Severity-of-asthma score          10.7 (6.8)           0.09
 Asthma quality-of-life score      18.8 (16.0)          0.27
 SF-36 physical summary score      41.7 (12.2)          0.007
 SF-36 mental summary score        47.2 (7.2)           0.04
ETS exposure
 Duration of exposure, past 7
  days (median, 25th-75th IQR)
  (b)                                0 (0-2)            0.33

IQR, interquartile range. All data are mean (SD) unless otherwise
indicated.

(a) A positive answer to a screening question for each location: home,
other person's home, work, car or vehicle, bar or nightclub, or other
location, (b) Based on initial interview.
Table 2. Prevalence of self-reported ETS exposure
among 50 subjects in ETS badge study.

Location              Number   Prevalence (%)

No exposure             12           24
Any exposure            38           76
Indoor/outdoor
 None                   12           24
 Indoor (a)             20           40
 Outdoor only           18           36
Work/home
 None                   12           24
 Work only              19           38
 Home only              5            10
 Both home and work     2            4
 Other only             12           24

Based on questionnaire administered after monitoring
period (validation interview).

(a) Includes 12 subjects with both indoor and outdoor exposure.
Table 3. ETS exposure by location among 50 adults with asthma.

                                         Exposure duration during
                                              past 7 days (hr)

                      No. exposed
                      during past
Location              7 days (%)    Minimum   Median   Mean   Maximum

Home                    7 (14)         0        0      2.3      50
Other person's home     8 (16)         0        0      0.3       8
Car or vehicle          6 (12)         0        0      0.5      20
Work--outdoor
 smoking  area (a)      21 (42)        0        3      5.5      40
Bar or nightclub        5 (10)         0        0      1.3      55
Other (b)               12 (24)       N/A      N/A     N/A      N/A
Total                   38 (76)        0        0      4.6      70

                         Exposure intensity among
                            exposed subjects

                      No. who smelled   No. who saw
Location                 smoke (%)       smoke (%)

Home                      6 (86)          6 (86)
Other person's home       8 (89)          3 (33)
Car or vehicle              N/A             N/A
Work--outdoor
 smoking area (a)         17 (63)           N/A
Bar or nightclub            N/A           3 (60)
Other (b)                   N/A             N/A
Total                     24 (48)         10 (20)

N/A, not asked.

(a) Number of times walked through smoking area (not hours of
exposure), (b) All were outdoor sites.
Table 4. Location of ETS exposure and measured nicotine exposure
level.

                                    Nicotine concentration
                                     ([micro]g/[m.sup.3])

                  No. of                      25th-75th   p-Value
Location         subjects   Median   Range       IQR        (a)

Indoor/outdoor                                             0.03
 None               12        0      0-0.06    0-0.035
 Outdoor only
  (b)               18       0.03    0-0.08    0-0.05
 Indoor             20       0.05    0-3.69    0-0.49
Home/work                                                  0.03
 None               12        0      0-0.06    0-0.035
 Work only          19       0.03    0-0.36    0-0.07
 Home (c)           7        0.61    0-3.69   0.02-3.03
Other location
 only               12      0.025    0-0.84    0-0.05
Total               50       0.03    0-3.69   0.03-0.06

IQR, interquartile range.

(a) Kruskall-Wallis test for comparison of nicotine concentration
between groups. (b) Sixty-one percent (n = 11/18) of subjects
who reported outdoor exposure only had detectable nicotine levels.
(c) Includes two subjects with both home and work ETS exposure.
Table 5. Validity of questionnaire measurement of ETS exposure.

                              Spearman correlation with
Questionnaire-based measure    nicotine concentration     p-Value

Exposure duration (hours/
 previous 7 days)                       0.47              0.0006
Score adjusted for exposure
 intensity(a)                           0.46              0.0007
Score adjusted for exposure
 intensity, sensory
 irritation symptoms, and
 respiratory symptoms (b)               0.45               0.001

(a) Score adjusted for exposure intensity had median 1.6, range 0-128,
25th-75th interquartile range 0.7-3.2. (b) Score adjusted for exposure
intensity, sensory irritation symptoms, and respiratory symptoms had
median 1.9, range 0-137, 25th-75th interquartile range 0.8:-5.0.
Table 6. ETS exposure (nicotine level) and the risk of sensory
irritation symptoms, respiratory symptoms, and extra bronchodilator
use.

                                                            Extra
                           Sensory       Respiratory    bronchodilator
Measured                  irritation       symptoms          use
nicotine level      n    (OR, 95% CI)    (OR, 95% CI)    (OR, 95% CI)

None (referent)     21       1.0             1.0             1.0
Lower level
 (0-0.05 [micro]g
 /[m.sup.3])        16   2.2 (0.3-15)   1.9 (0.4-8.8)    2.2 (0.3-15)
Higher level
 (>0.05 [micro]g
 /[m.sup.3])        13   5.9 (0.95-37)  6.8 (1.4-32.3)   8.1 (1.3-50)
p-Value for trend           0.054           0.017           0.022

* Sensory irritation symptoms: eye or nose irritation; respiratory
symptoms: cough, wheezing, or dyspnea.

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Mark D. Eisner, (1) Patricia P. Katz, (2) Edward H. Yelin, (2) S. Katharine Hammond, (3) and Paul D. Blanc (1)

(1) Division of Occupational and Environmental Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, and (2) Institute for Health Policy Studies and Department of Medicine, University of California, San Francisco, San Francisco, California, USA; (3) Center for Occupational and Environmental Health and School of Public Health, University of California, Berkeley, California, USA

Address correspondence to M.D. Eisner, Division of Occupational and Environmental Medicine and Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, 350 Parnassus Avenue, Suite 609, San Francisco, CA 94117 USA. Telephone: [phone]. Fax: [phone]. E-mail: [e-mail]

This study was supported by National Research Service award F32 HL0054 and NIH K23 HL04201 (to M.D. Eisner) and NIH RO1 HL56438 (to P.D. Blanc).

Received 18 December 2000; accepted 16 February 2001.