Magnesium sulfate complications. (Pregnancy & Birth).Mothers given magnesium sulfate magnesium sulfate n. A colorless crystalline compound used as a cathartic and applied locally as an anti-inflammatory agent. magnesium sulfate Warning - High-alert drug! as a tocolytic as an attempt to stop preterm labor contractions may be more likely to have babies with negative outcomes. The studied effect was dose-related and correlated with ionized i·on·ize tr. & intr.v. i·on·ized, i·on·iz·ing, i·on·iz·es To convert or be converted totally or partially into ions. i magnesium levels in cord blood, leading investigators to suggest that magnesium sulfate should no longer be used. "Contrary to original hypotheses, this randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. trial found that the use of prenatal magnesium sulfate was associated with worse, not better, perinatal outcome in a dose-response fashion," said Robert Mittendorf, MD, DRPH, from Loyola University Medical Center Loyola University Medical Center, founded in 1969 by Loyola University as its teaching hospital, is a Level I Trauma Center located in Maywood, Illinois, west of Chicago. The hospital complex includes the Ronald McDonald Children's Hospital and the Joseph Cardinal Bernardin Cancer Center. and colleagues. Scientists studied 149 mothers in preterm labor. The mothers were treated with magnesium sulfate, another medicine, or a placebo. Neonatal cranial cranial /cra·ni·al/ (-al) 1. pertaining to the cranium. 2. toward the head end of the body; a synonym of superior in humans and other bipeds. cra·ni·al adj. ultrasound diagnosed intraventricular hemorrhage and periventricular leukomalacia; cerebral palsy in survivors was diagnosed at 18 months of age. Children with adverse outcomes had higher umbilical cord magnesium levels at birth. Even after controlling for very low birth weight, magnesium remained a significant risk factor for poor outcome. "We recommend abandoning magnesium sulfate for routine use as a tocolytic therapy," the authors write. "On the basis of the findings of this study and our recent literature review ... we believe that the scientific support for tocolytic magnesium sulfate is tenuous and, accordingly, that its use in that setting should be restricted to the confines of controlled clinical trials." --American Journal of Obstetrics and Gynecology obstetrics and gynecology Medical and surgical specialty concerned with the management of pregnancy and childbirth and with the health of the female reproductive system. , June 2002 |
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