MWG Biotech expands siMAX siRNA Portfolio with New Scales, Lengths and Design Tools.EBERSBERG, Germany -- Nucleic acids Nucleic acids The cellular molecules DNA and RNA that act as coded instructions for the production of proteins and are copied for transmission of inherited traits. specialist MWG MWG Men with Guts (sports apparel company) MWG Match-Winning Goal (soccer) mWG Microworld of Gems (e-commerce business) MWG Measurements Working Group MWG Model Working Group Biotech, Ebersberg, Germany, announces the extension of their siRNA portfolio (small interfering RNA Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. - used for analyzing the function of genes and for silencing gene activity), with the addition of multiple scales and siRNA in either the classical 21mer or the new 27mer format, plus a new advanced siRNA online design tool. MWG offers licensed high quality custom siRNA and pre-designed siRNA synthesis, produced with proprietary siMAX(TM) technology (an advanced TBDMS- based synthesis chemistry) which allows reliable synthesis, high coupling yields and greatly reduced interfering n-x products in fast turn-around time. MWG Biotech sells the new MWG siRNA products under the siMAX(TM) brand name. MWG Biotech now offers three different scales (0.05 imol, 0.2 imol, and 1.0 imol), with improved yields on the already existing 0.2 imol scale. siRNA can be ordered in either the standard 21mer or in 27mer format. This new format has recently attracted much scientific interest as it is assumed to provide a higher efficiency in comparison to the 'classical' 21mer siRNA. As an extra benefit, MWG Biotech is proud to offer the first commercial design program to view mRNA accessibility. Customers can view the secondary structure of the siRNA/mRNA target site to select designs in regions of optimal secondary structure in order to improve silencing efficiency. In addition, the Company's unique on-line design tool set gives customers access to the latest bioinformatics design algorithms. siRNA candidate sequences can also undergo Blast analysis to reduce off-target effects. All siMAX(TM) siRNA molecules are delivered annealed, purified (desalted or HPLC-purified) and ready to use. All products are normalized to ensure optimum duplex formation. Each single strand of RNA RNA: see nucleic acid. RNA in full ribonucleic acid One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic is analyzed by MALDI-TOF MALDI-TOF Matrix Assisted Laser Desorption Ionization - Time of Flight mass spectrometry mass spectrometry or mass spectroscopy Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields. and Capillary Gel Electrophoresis gel electrophoresis n. Electrophoresis performed in a gel composed of agarose, polyacrylamide, or starch. (CGE CGE Computable General Equilibrium CGE Conference des Grandes Ecoles (French) CGE Carrier Grade Edition (COTS Linux platform) CGE Classic Gaming Expo (game) ). MALDI-TOF mass spectrometry is used to confirm the sequence identity of the individual single strands. Purity of the strands is then confirmed using CGE analysis. Both MALDI-TOF and CGE traces of the single strands are provided free of charge. About MWG Biotech AG: MWG Biotech (www.mwg-biotech.com) is an international provider of DNA sequencing and DNA/siRNA synthesis products and services for academic and industrial research from production sites in Germany, the US, and India. With strong customer orientation, fast service and high quality products the company creates the platform for success in the life sciences today and for a better life tomorrow. |
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