Lupus; Overview.Achy, swollen joints; fever; skin rashes; fatigue--these are some of the more typical symptoms of systemic lupus erythematosus Systemic Lupus Erythematosus Definition
Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. (SLE SLE systemic lupus erythematosus.
systemic lupus erythematosus
Systemic lupus erythematosus (SLE) ), a chronic, inflammatory disorder of the immune system that affects several body systems simultaneously. Approximately 1.5 million to 2 million people in the United States have some form of lupus, and, according to the Lupus Foundation of America The Lupus Foundation of America (LFA) is the nation's leading non-profit voluntary health organization dedicated to finding the causes of and cure for lupus. The LFA was founded in 1977, and currently operates a nationwide network of almost 300 chapters, branches and support groups. , the number may be even higher.
SLE is classified as an autoimmune disorder because the body's immune system, which normally fights harmful bacteria and viruses, also targets healthy tissue, sometimes including skin, joints, kidneys, brain, heart and lungs. The condition can result in immediately serious or life-threatening problems or in chronic low-grade symptoms, such as fatigue and muscle aches, which affect the quality of life.
In Latin, lupus means wolf, and erythematosus means redness. Physicians who first described the disease thought that one of its characteristic rashes looked liked a wolf bite. The terms "SLE" and "lupus" are often used interchangeably, but there are several kinds of lupus, including:
Systemic lupus erythematosus (SLE) can affect almost any organ or system in the body. In some people with systemic lupus, only the skin and joints are involved; in others, the joints, lungs, kidneys, blood, or other organs and/or tissues are all affected. Any two people with systemic lupus will be unlikely to have all the same symptoms. Systemic lupus may include remission periods during which few or no symptoms are evident and "flares," when the disease becomes active.
Discoid lupus erythematosus Discoid Lupus Erythematosus Definition
Discoid lupus erythematosus (DLE) is a disease in which coin-shaped (discoid) red bumps appear on the skin. (DLE (character) DLE - Data Link Escape, the mnemonic for ASCII 16. ), also called cutaneous lupus, involves the development of lesions on the face or other sun-exposed areas. The lesions are abnormally red, raised, hard bumps or plaques. They may include an overgrowth of scaly tissue, plugged hair follicles and abnormally widened small blood vessels. Thinning of the healing skin, called atrophic scarring, as well as loss of color in the skin, called dyspigmentation, may occur in older lesions. If the condition involves the scalp, there may be permanent scarring and loss of hair. Lesions are usually on the face or other sun-exposed areas. Many people have DLE without SLE. In approximately 10 percent of these cases, DLE later progresses to the more severe SLE. This is more likely to happen in patients with lesions both above and below the neck.
Drug-induced lupus is caused by certain medications, the most common being: procainamide (Pronesyl), used for heart rhythm abnormalities; hydralazine hydralazine /hy·dral·a·zine/ (hi-dral´ah-zen) a peripheral vasodilator used in the form of the hydrochloride salt as an antihypertensive.
n. (Hydra-Zide), used for high blood pressure; and isoniazid isoniazid (ī'sōnī`əzĭd), drug used to treat tuberculosis. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. (Nydrazid), used for tuberculosis. Drug-induced lupus usually doesn't affect the kidneys or central nervous system and typically improves when the drug is discontinued.
Neonatal lupus, a very rare condition in newborns, results from the passage of autoantibodies from the mother to her baby, specifically anti-Ro/SSA or anti-La/SSB, which can affect the skin, heart and blood of the fetus and newborn. The most common symptom of neonatal lupus is an uncomplicated rash that appears within the first several weeks of life, which may persist for about six months before disappearing. Less frequently, fetuses with neonatal lupus develop a congenital heart block. However, many of these babies do well with a pacemaker at birth. If a fetal heart condition is identified early enough during pregnancy, it might be possible to treat it with steroids or immunoglobulins.
In general, women are far more likely than men to develop autoimmune disorders, and SLE certainly fits that paradigm, occurring 10 times more frequently among adult women than among men. It is also more common in African-Americans, American Indians and Asians than in Caucasians. Although lupus can develop at any age, it is usually diagnosed in women during their childbearing years.
If you have a parent, child, or sibling with lupus, your risk of developing the disease is somewhat higher, although your health care professional probably won't test you for the disease unless you develop symptoms. There is no known cure for SLE, but there are treatments designed to minimize symptoms and effects.
There is a genetic component in lupus, but it is a complicated kind of inheritance, involving many genes interacting to determine a person's risk. Genes are blueprints for the proteins that do the work of the body, and to protect the body from invaders, the immune system involves a huge army of these proteins. Small inherited differences in any one of these proteins might cause it to underreact un·der·re·act
intr.v. un·der·re·act·ed, un·der·re·act·ing, un·der·re·acts
To react with insufficient enthusiasm, force, or emphasis.
un or overreact o·ver·re·act
To react with unnecessary or inappropriate force, emotional display, or violence. in an immune system maneuver. Any one small difference is unlikely to cause a health problem. Therefore, it is thought that people who develop lupus may have inherited a number of small differences and not necessarily the same differences from patient to patient. Why do these differences exist? If every human had an identical immune system, it is likely that some infection would have destroyed our species a long time ago. Diversity in these small inherited blueprints for our proteins is essential for the survival of the human race. In lupus, it may be that a person was simply dealt a bad hand. Multiple areas of the genome are being investigated for potential contributions to some or all lupus cases.
The number and type of lupus symptoms vary widely among patients. Symptoms also tend to wax and wane, with patterns of inactive disease bracketed by lupus "flares."
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"Lupus is a Significant Health Issue for Women and People of Color Noun 1. people of color - a race with skin pigmentation different from the white race (especially Blacks)
people of colour, colour, color
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Keywords: lupus, systemic lupus erythematosus, sle, symptoms, autoimmune disorder, immune system, dle, women, drugs