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Long-term tamoxifen use may up aggressive breast cancer risk.

Byline: ANI

Washington, Aug 26 (ANI): Tamoxifen tamoxifen (təmŏk`sĭfĕn'), synthetic hormone used in the treatment of breast cancer. Introduced in 1978, tamoxifen is used to prevent recurrences of cancer in women who have already undergone surgery to remove their tumors.  drug, commonly used for treating breast cancer, can actually increase the severity of the disease, finds a new study.

The researchers showed that long-term Long-term

Three or more years. In the context of accounting, more than 1 year.


long-term

1. Of or relating to a gain or loss in the value of a security that has been held over a specific length of time. Compare short-term.
 tamoxifen use increases risk of an aggressive, hard to treat type of second breast cancer.

Lead researcher Dr Christopher Li at Fred Hutchinson
This article is about Fred Hutchinson, the American baseball player and manager. For the medical institution established by his brother in his memory, see Fred Hutchinson Cancer Research Center.
 Cancer Research Centre compared the breast-cancer patients who received the estrogen-blocking drug tamoxifen to those who did not and found that while the drug was associated with a 60 percent reduction in estrogen receptor-positive, or ER positive, second breast cancer - the more common type, which is responsive to estrogen-blocking therapy - it also appeared to increase the risk of ER negative second cancer by 440 percent.

"This is of concern, given the poorer prognosis prognosis /prog·no·sis/ (prog-no´sis) a forecast of the probable course and outcome of a disorder.prognos´tic

prog·no·sis
n. pl. prog·no·ses
1.
 of ER-negative tumors, which are also more difficult to treat," said Li.

The findings from the new study supports Li's earlier research suggesting a link between long-term tamoxifen use and an increased risk of ER-negative second cancers.

"The earlier study had a number of limitations. For example, we did not have information on the duration of tamoxifen therapy the women received," said Li.

"The current study is larger, is based on much more detailed data, and is the first study specifically designed to determine whether tamoxifen use among breast cancer survivors Cancer survivors are those individuals with cancer of any type, current or past, who are still living. The National Coalition for Cancer Survivorship (NCCS) pioneered the definition of survivor as from the time of diagnosis and for the balance of life, a person diagnosed with  influences their risk of different types of second breast cancers," the expert added.

However, Li insists that while the study confirmed a strong association between long-term tamoxifen therapy and an increased risk of ER-negative second cancer, it does not suggest that breast cancer survivors should stop taking hormone therapy Hormone therapy
Treating cancers by changing the hormone balance of the body, instead of by using cell-killing drugs.

Mentioned in: Breast Cancer, Thyroid Cancer

hormone therapy 
 to prevent a second cancer.

The findings are published in the journal Cancer Research. (ANI)

Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency.  (ANI) - All Rights Reserved.

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Publication:Asian News International
Date:Aug 26, 2009
Words:299
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