Liver library.Johnson & Johnson's pharmaceutical research and development division has contributed a library of expression profiles for 100 paradigm compounds, primarily hepatotoxicants, to the Chemical Effects in Biological Systems (CEBS CEBS Committee of European Banking Supervisors CEBS Certified Employee Benefit Specialist CEBS Chemical Effects in Biological Systems CEBS Church of England Boys Society CEBS Charles Edward Brooke School (UK) ) knowledge base based at the National Center for Toxicogenomics, a part of the NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) . CEBS users can select arrays corresponding to one or more compounds from the library and use knowledge base tools to identify genes with significantly changed transcript levels. Lists of altered genes can then by annotated with current annotation provided by CEBS or projected onto biological pathways from groups like BioCarta, KEGG KEGG Kyoto Encyclopedia of Genes and Genomes , and the Gene Ontology The Gene Ontology project, or GO, provides a controlled vocabulary to describe gene and gene product attributes in any organism. It can be broadly split into two parts. Consortium. CEBS is accessed at http://cebs.niehs.nih.gov/. |
|
||||||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion