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Lifeline's First Warning System Used in Peer-Reviewed Paper Published by International Seminars in Surgical Oncology: Abstract of This Paper Resulted in 400 Requests for Entire Clinical Paper in First Two Days.


FT. LAUDERDALE, Fla. -- Paper Comments on the Evolving Role of Dynamic Thermal Analysis Thermal analysis is a branch of materials science where the properties of materials are studied as they change with temperature. Techniques include:
  • Differential scanning calorimetry
  • Dynamic mechanical analysis
  • Thermomechanical analysis
 in the Early Detection of Breast Cancer

Lifeline Biotechnologies, Inc. (OTC OTC

See: Over-the-counter.


OTC

See over-the-counter market (OTC).
:LBTN LBTN Land Based Test Network (Space & Naval War Systems Command)
LBTN Low Bandwidth Tactical Network
LBTN Link Button
) today announced that a peer-reviewed article authored by Drs. M. Salhab, W. Al Sarakbi, K. Mokbel of St. George's Noun 1. St. George's - the capital and largest city of Grenada
capital of Grenada

Grenada - an island state in the West Indies in the southeastern Caribbean Sea; an independent state within the British Commonwealth
 and The Princess Grace Hospitals in London, UK, and Professor Kefah Mokbel, MS, FRCS FRCS Fellow of the Royal College of Surgeons.

FRCS
abbr.
Fellow of the Royal College of Surgeons
, Professor at Brunel Institute of Cancer Genetics and Consultant Breast & Endocrine Surgeon at The Princess Grace Hospital, in London, has demonstrated that there is a future role for the use of dynamic thermal analysis in the early detection of breast cancer - particularly among young women with dense breast tissue.

In a paper published this month by the International Seminars in Surgical Oncology surgical oncology Oncological surgery The field of surgery dedicated to the operative ablation of neoplasia, generally, 'solid' tumors , the authors outlined the potential of this technology, noting that cancer development appears to generate its own thermal signatures and the complexity of these signatures may be a reflection of its degree of development.

The article "focuses on dynamic thermal analysis as an evolving method in breast cancer detection in pre-menopausal women with dense breast tissue. Prospective multi-center trials are required to validate this promising modality modality /mo·dal·i·ty/ (mo-dal´i-te)
1. a method of application of, or the employment of, any therapeutic agent, especially a physical agent.

2.
 in screening." The article also addresses an issue of false positives that require further investigation using molecular genetic markers of malignancy and novel techniques such as mammary mammary /mam·ma·ry/ (mam´ah-re) pertaining to the mammary gland, or breast.

mam·ma·ry
adj.
Of or relating to a breast or mamma.



mammary

pertaining to the mammary gland.
 ductoscopy.

"This article clearly states that thermal imaging could be a valid means for the early detection of breast cancer, particularly in those young women whose breast tissue is quite dense as well as those who have a family history of breast cancer," said Dr. William Reeves

For other people named William Reeves, see William Reeves (disambiguation).


William Reeves, also known as Bill, is a pioneer in the field of computer graphics.
, founder of Lifeline and developer of the First Warning System(TM), which is a non-invasive system that monitors the minute temperature changes in a woman's breast and through proprietary algorithms to allow for early diagnosis of breast cancer. Lifeline believes it is the only company with this type of product under development.

According to according to
prep.
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

3.
 the article, the First Warning System(TM) facilitates the recording of circadian rhythm circadian rhythm: see rhythm, biological.
circadian rhythm

Inherent cycle of approximately 24 hours in length that appears to control or initiate various biological processes, including sleep, wakefulness, and digestive and hormonal activity.
 variations of the breast and analyzes this data using highly complicated statistical software. A miniaturized microprocessor records and stores thermal information that is collected from eight separate sites of each breast by monitors that are affixed af·fix  
tr.v. af·fixed, af·fix·ing, af·fix·es
1. To secure to something; attach: affix a label to a package.

2.
 to the breast, much in the same way an electrocardiogram electrocardiogram /elec·tro·car·dio·gram/ (-kahr´de-o-gram?) a graphic tracing of the variations in electrical potential caused by the excitation of the heart muscle and detected at the body surface.  is used. "The sensors are placed in critical positions on the breast that have been determined as areas where cancers are most likely to develop," said Dr. Reeves.

In the First Warning System(TM), this thermal data is collected every five minutes over a 48-hour period. Some 9,000 pieces of data are recorded by microprocessors and analyzed. Temperature points from each sensor are plotted against each other to form a thermal motion Thermal motion is motion on the scale of molecules caused by heat. Brownian motion is an example of a phenomenon caused by thermal motion.  picture of a lesion's physiological activity.

In its proof of concept study in 1989
Total number of open biopsies:  169
Characteristics of the biopsy population
         Mean age of biopsy population                  44  yrs
         Age range of breast biopsy population          19 to 77  yrs
         Mean age of the breast cancer population       52  yrs
         Age range of breast cancer patients            35 to 72  yrs
         The average number of positive lymph nodes     1.17
                   Range                                0 to 16 nodes
         Average tumor size                             1.75 cms
                   Range                                from
                                                         microscopic
                                                         to 4.5 cms

There were 32* Patients positive for breast cancer
         Cancers found by mammography                   25**
         Cancers found by Lifeline's First Warning
          System(TM)(FWS):
                   Neural net analysis                  30***
                   Wavelet analysis                     31
                   Wavelet/neural net analysis          32

* Four cancers in the series were eliminated from consideration by
either statistical or neural network because of bad data. For the
purposes of this study the adjusted number of cancers will is 32.

** Of the seven cancers missed by mammography, six were found by
the FWS, all were under the age of fifty with tumors ranging in size
from 0.5cms, to 3.5cm all in dense breast tissue. In addition two
patients in the series had mammograms taken at another facility,
therefore mammographic results were not available for the purposes of
this study.

*** Four cancers produced a mirror image high-risk response in the
opposite breast, which may be considered a paradoxical reaction,
although the possibility of operator error might account for these
findings. Since, four other cases with reversed reading results were
discovered during the course of the study and were directly
attributable to operator error on lead harness reversal.



The term "false positive" should be used with great caution since the monitor is designed to measure physiological data and not anatomical variations. Patients with a positive reading in the absence of mammographic or physical findings of cancer should be considered at "high risk" for the disease which may become clinically evident at some future date.

"We believe we have a very promising product in development and remain hopeful that upon completion of clinical development and future clinical trials, the First Warning System(TM) will be recognized as a safe, non invasive approach that is can help in the early detection of breast cancer - especially in young women where conventional mammography mammography, diagnostic procedure that uses low-dose X rays to detect abnormalities in the breasts. The early diagnosis of breast cancer made possible by the routine use of mammography for screening women increases a woman's treatment alternatives and improves her  is of limited value. We believe that our First Warning System(TM) could become the initial breast screening tool for pre-menopausal women and those who are classified as positive can then be selected for anatomical imaging with mammography," Reeves said.

Lifeline Biotechnologies, Inc. is a company with innovative medical technologies committed to the improvement of the quality of life through exceptional health care systems. These technologies focus on prevention, early detection, diagnosis and quick recovery of a number of disease conditions. The company's Cancer Detection technologies deal with cutting edge innovation to assist practicing physicians in the delivery of quality medical care. The MastaScope(TM) is used in the early detection of cancer and other abnormalities of the breast. The MastaScope(TM) has completed development and has entered the marketplace in the US and internationally. The First Warning System(TM) for assisting in the early detection of breast cancer and the OvaScope(TM) for assisting in the early detection of ovarian cancer ovarian cancer

Malignant tumour of the ovaries. Risk factors include early age of first menstruation (before age 12), late onset of menopause (after age 52), absence of pregnancy, presence of specific genetic mutations, use of fertility drugs, and personal history of breast
 are continuing to be developed by the company. More information is available at the company's website: www.lbti.com.

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. In particular, when used in the preceding discussion, the words, "believe", "expects", "projects", "forecasts", "intends", "will", "anticipated", "could", or "may", and similar conditional expressions are intended to identify forward-looking statements within the meaning of the act and are subject to the safe harbor Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
 created by the act. Except for historical information, all of the statements, expectations and assumptions contained in the foregoing are forward-looking statements that involve a number of risks and uncertainties.
COPYRIGHT 2005 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2005, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1USA
Date:Apr 21, 2005
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