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Lemierre's syndrome.


Lemierre's syndrome is characterized by thrombophlebitis of the internal jugular vein internal jugular vein
n.
A vein that is a continuation of the sigmoid sinus of the dura mater and unites behind the cartilage of the first rib with the subclavian vein to form the brachiocephalic vein.
 and a spreading secondary infection. (1,2) When it occurs, it usually does so in young, previously healthy patients following an oropharyngeal infection accompanied by a persistently high fever. The overall incidence of this syndrome appears to be increasing.

The primary pathogen in Lemierre's syndrome is Fusobacterium
1. A rod-shaped bacterium in which the cell is thicker in the center and tapers toward the ends.
2. an organism of the genus Fusobacterium.


Fu·so·bac·te·ri·um (fy
 neerophorum, a gram-negative rod that normally inhabits the oropharynx. (1,2) Prolonged antibiotic treatment with good anaerobic coverage is vital to minimizing morbidity and mortality; the mortality rate associated with Lemierre's syndrome prior to the antibiotic era was nearly 90%. (3) Today, with early diagnosis and treatment, the mortality rate has decreased to 15%. (3)

We evaluated a 21-year-old black man who presented with exudative tonsillitis and high fever. He had no significant medical history. Computed tomography (CT) of the neck detected a thrombosis of the right anterior jugular vein anterior jugular vein
n.
A vein that arises below the chin from the veins draining the chin and lower lip, passes down the front of the neck superficially, and terminates in the external jugular vein at the lateral border of the anterior scalene muscle.
 that extended from the level of the hyoid
1. Shaped like the letter U.
2. Of or relating to the hyoid bone.
n.
The hyoid bone.
 to the supraclavicular area (figure, A). CT of the chest revealed multiple cavitary
1. Relating to or having a cavity or cavities.
2. Of, relating to, or being an animal parasite that has a body cavity and lives within the host's body.
 pulmonary nodules throughout the pulmonary parenchyma (figure, B). Blood cultures were positive for F necrophorum, and the patient was treated with an appropriate antibiotic. A follow-up CT of the neck 4 weeks later showed a partial resolution of the thrombosis (figure, C).

In the presence of appropriate clinical features, the clinician should consider Lemierre's syndrome when cross-sectional imaging of the neck and chest demonstrates a thrombosed internal jugular vein and multiple septic emboli emboli /em·bo·li/ (em´bo-li) plural of embolus..

References

(1.) Gormus N, Durgut K, Ozergin U, et al. Lemierre's syndrome associated with septic pulmonary embolism
air embolism  that due to air bubbles entering the veins from trauma, surgical procedures, or severe decompression sickness.
cerebral embolism  embolism of a cerebral artery.
coronary embolism  embolism of a coronary artery.
: A case report. Ann Vasc Surg 2004; 18:243-5.

(2.) Sagowski C, Koch U. [Lemierre syndrome: Thrombosis of the internal jugular vein after tonsillectomy]. HNO HNO - Hals Nasen Ohrenheilkunde
HNO - Hals-Nasen-Ohren Heilkunde (German: throat, nose and ear medicine)
HNO - Harvard News Office
HNO - Helvetica Narrow Oblique (font)
HNO - Host Network Operator
HNO - Hungarian National Observatory
 2004;52:251-4.

(3.) Weesner CL, Cisek JE. Lemierre syndrome: The forgotten disease. Ann Emerg Med 1993;22:256-8.

David Kirsch, MD; Devin Tighe, MD; Michael G. D'Antonio, MD; Enrique Palacios, MD, FACR FACR - Facilities Engineering & Design Requirements
FACR - Fellow of the American College of Radiology
FACR - Fellow of the American College of Rheumatology
FACR - First Article Configuration Review
 

From the Department of Radiology, Louisiana State University Health Sciences Center and VA Medical Center, New Orleans.
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No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Article Details
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Title Annotation:Imaging Clinic; thrombophlebitis of jugular vein
Author:Palacios, Enrique
Publication:Ear, Nose and Throat Journal
Geographic Code:1U7LA
Date:Dec 1, 2004
Words:334
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