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Large Scale Biology Corporation Enters Research Phase for Development of Atherosclerosis Therapeutic.


Business Editors/Health/Medical Writers

VACAVILLE, Calif.--(BUSINESS WIRE)--March 4, 2004

Large Scale Biology Corporation's (Nasdaq:LSBC LSBC Law Society of British Columbia
LSBC Large Scale Biology Corporation
LSBC Lone Star Bulldog Club
LSBC Lasalle & Bureau County Railroad Company
LSBC Lifesaver for Babies and Children (St John Ambulance, UK)
LSBC Lone Star Bit Company
) exclusive license agreement with Cincinnati Children's Hospital Medical Center Cincinnati Children's Hospital Medical Center is a hospital in Cincinnati, Ohio. In June of 1883, a meeting of women from parish communities around Cincinnati established a mission to create a Diocesan Hospital for Children.  for the development of a drug to treat a leading cause of death in the U.S. has entered an initial development stage.

Dr. Gregory A. Grabowski, M.D. co-authored a recent article published in the American Heart Association American Heart Association (AHA),
n.pr a national voluntary health agency that has the goal of increasing public and medical awareness of cardiovascular diseases and stroke, and thereby reducing the number of associated deaths and disabilities.
 journal, Arteriosclerosis arteriosclerosis (ärtĭr'ēōsklərō`sis), general term for a condition characterized by thickening, hardening, and loss of elasticity of the walls of the blood vessels. , Thrombosis and Vascular Biology, describing decreases in atherosclerotic plaque Atherosclerotic plaque
A deposit of fat and other substances that accumulate in the lining of the artery wall.

Mentioned in: Atherectomy

atherosclerotic plaque 
 in mice on high fat diets when lysosomal lysosomal

pertaining to or emanating from lysosomes.


lysosomal enzymes
enzymes located in the lysosomes.

lysosomal phospholipidosis
 acid lipase (LAL LAL Laughing A Lot
LAL Los Angeles Lakers
LAL Lithuanian Airlines
LAL Lightning Activity Level (used for wildfire prediction)
LAL Limulus Amoebocyte Lysate
LAL Latitude and Longitude
LAL Live and Learn
) was administered. Coronary and aortic aortic

pertaining to or emanating from the aorta. See also aortic arch.


aortic aneurysm
occurs most often in dogs, where it is caused by Spirocerca lupi larvae, turkeys and primates, causing dyspnea, cyanosis and coughing.
 plaque were eliminated in early stages and reduced quantitatively and qualitatively in advanced stages.

The initial research phase will be conducted at Cincinnati Children's Hospital Medical Center under the direction of Dr. Grabowski. Large Scale Biology Corporation will produce LAL for clinical applications as well as seek commercial partners for the drug.

About Cincinnati Children's Hospital Medical Center

Cincinnati Children's Hospital Medical Center is a 373-bed institution dedicated to the pursuit of perfect health care. It is the only pediatric pediatric /pe·di·at·ric/ (pe?de-at´rik) pertaining to the health of children.

pe·di·at·ric
adj.
Of or relating to pediatrics.
 organization in the United States to receive the prestigious Pursuing Perfection grant from the Robert Wood Johnson Foundation Robert Wood Johnson Foundation, charitable organization devoted exclusively to health care issues. It was established in 1936 by Robert Wood Johnson (1893–1968), board chairman of the Johnson & Johnson medical products company. . The Cincinnati Children's Research Foundation ranks third nationally among all pediatric centers in research grants from the National Institutes of Health. The Cincinnati Children's vision is to be the leader in improving child health, through patient care, research and education. Additional information about Cincinnati Children's can be found at www.cincinnatichildrens.org.

About Large Scale Biology Corporation

Large Scale Biology uses its biomanufacturing, functional genomics and proteomics technologies to develop and manufacture drugs, vaccines and diagnostics for effective treatment of disease. Corporate offices, the Genomics Division, the Proteomics Division, and Biopharmaceutical Development laboratories, and Eclipse Diagnostics, Inc., are headquartered in Vacaville, Calif., and the Company's commercial-scale biomanufacturing facility is located in Owensboro, Kentucky. For more information about Large Scale Biology Corporation, visit the Company's website at www.lsbc.com.

This release contains forward-looking statements about an application of LSBC's technologies and the market for one of our products under development. These forward-looking statements involve risks, uncertainties and situations that may cause our actual results to differ materially from those implied by these statements, including our ability to produce adequate quantities of product, the ability of our collaborators to generate demand for products we make for them, the effectiveness of our and our collaborators' technologies to produce specific therapeutic products and/or in a cost-effective manner, any difficulties or delays in obtaining regulatory approval to test and market such products, and the requirement of substantial funding for us to preserve our technology base and product pipeline. We cannot guarantee future results. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this release. For a further list and description of such risks and uncertainties see the reports filed by Large Scale Biology Corporation with the Securities and Exchange Commission, including our reports on Forms 10-K and 10-Q. Except as required by law, we do not undertake to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.

LSBC(TM) is a trademark of Large Scale Biology Corporation.
COPYRIGHT 2004 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Mar 4, 2004
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