Printer Friendly

Landmark Papers in Cell Biology.

Landmark Papers in Cell Biology. Joseph G. Gall and J. Richard McIntosh, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory The Cold Spring Harbor Laboratory  Press, 2000, 554 pp., hardcover, $45.00. ISBN 0-87969-602-8.

The American Society for Cell Biology is celebrating its 40th anniversary with the publication of this collection of significant papers in their field. It is impressive to see before you the growth of knowledge of the functioning of the living cell since 1957, the date of the earliest included publication: J.H. Taylor, P.S. Woods, and W.L. Hughes (Proc Natl Acad Sci) explain the organization and duplication of chromosomes duplication of chromosomes
n.
The occurrence of a repeated section of genes in a chromosome.
 using autoradiography Autoradiography

A photographic technique used to localize a radioactive substance within a solid specimen; also known as radioautography.

A photographic emulsion is placed in contact with the object to be tested and is left for several hours, days, or
 with tritiated thymidine.

The papers were nominated by the editorial board of Molecular Biology of the Cell Molecular Biology of the Cell (MBC) is a scientific journal published monthly online and in print by the American Society for Cell Biology. MBC publishes original and scholarly research reports that contribute to the scientific understanding of the molecular basis of cell structure  and chosen by editors Gall and McIntosh, both eminent cell biologists. They restricted the selection to studies on eukaryotes and generally omitted papers that were purely biochemical, genetic, or developmental in their nature. The 42 papers selected cover the following themes: genome organization and replication; transcription; nuclear envelope and nuclear import; mitosis and cell cycle control; cell membrane and extracellular matrix; protein synthesis and membrane traffic; and cytoskeleton. A brief commentary precedes each article to explain its historical significance.

As a biochemist who joined the Society at its founding to better understand the workings of the cell, I found the papers to be both nostalgic and informative. Although the essence of major advances appears in digested form in textbooks and review articles, one can better appreciate the excitement of their appearance by reading the originals. Compare reading reviews of evolution with reading Darwin's The Origin of Species.

Among the papers that I consider to be classics (with their subjects italicized) are the following: Formation and detection of RNA-DNA hybrid molecules in cytological preparations, J.G. Gall and M.L. Pardue (1969); Visualization of nucleolar nucleolar

pertaining to or emanating from nucleolus.
 genes, O.L. Miller, Jr. and B.R. Beatty (1969); A large particle associated with the perimeter of the nuclear pore complex, P.N.T. Unwin and R.A. Milligan (1982); Cell motility by labile association of molecules. The nature of mitotic spindle fibers and their role in chromosome movement, S. Inoue and H. Sato (1967); Fracture faces of frozen membranes, D. Branton (1966); The fluid mosaic model of the structure of cell membranes, S.J. Singer and G.L. Nicolson (1972); Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen zymogen
 or proenzyme

Any of a class of proteins that are secreted by cells and are inactive precursors of enzymes. Transformation into active enzymes occurs as one or more peptide bonds in the zymogen are cleaved.
 granules, J.D. Jamieson and G.E. Palade (1967); Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma, G. Blobel and B. Dobberstein (1975; discovery of the signal peptide); and Studies on the microtubules in Heliozoa. II. The effect of low temperature on these structures in the formation and maintenance of the axopodia, L.G. Tilney and K.R. Porter (1967).

The reproduction of the original articles is excellent, including many transmission electron micrographs and the striking freeze-fracture pictures of the cell membrane. The volume is reasonably priced and is recommended for those interested in the background of our knowledge of the cell.

Research Institute

Bassett Healthcare
COPYRIGHT 2001 American Association for Clinical Chemistry, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001 Gale, Cengage Learning. All rights reserved.

 Reader Opinion

Title:

Comment:



 

Article Details
Printer friendly Cite/link Email Feedback
Author:Peters, Theodore, Jr.
Publication:Clinical Chemistry
Date:Nov 1, 2001
Words:523
Previous Article:EP Evaluator-CLIA (EE-CLIA) for Evaluating Clinical Laboratory Methods (Consultant's Version with Rapid Results Entry).
Next Article:Correction.


Related Articles
Nanoscale materials science in biology and medicine; proceedings.
Landmark Papers in Yeast Biology. (CD-ROM included).
Vital Harmonies.
Thomson Scientific Examines Biology's Hottest Institutions, Authors and Journals.
Thomson Scientific Examines Biology's Hottest Institutions, Authors and Journals.
Zebrafish Journal Publishes Skin Pigmentation Studies That Shed Light on the Evolution of Race.
Collected works of Shinya Inoue; microscopes, living cells, and dynamic molecules. (CD-ROM included).
Regulatory networks in stem cells.
Journal retracts sperm-creation paper over plagiarism.
Trends in stem cell biology and technology.

Terms of use | Copyright © 2014 Farlex, Inc. | Feedback | For webmasters