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Kyowa Hakko Kogyo Licenses Anti-tumor Drug Candidate Mitotic Kinesin Eg5 Inhibitor to Eli Lilly.


Tokyo, Japan, Jan 11, 2006 - (JCN JCN Japan Corporate News
JCN Journal of Cognitive Neuroscience
JCN Journal of Cardiovascular Nursing
JCN Journal of Christian Nursing
JCN Job Control Number
JCN Journal of Child Neurology
JCN joint communications network (US DoD) 
) - Kyowa Hakko Kogyo announced on January 10 that it has signed a licensing agreement with US pharmaceutical company Eli Lilly Eli Lilly can refer to:
  • Eli Lilly and Company, a global pharmaceutical company
  • Colonel Eli Lilly (1839-1898), founder of Eli Lilly and Company
  • Eli Lilly (industrialist) (1885-1977), former president of Eli Lilly and Company
 on mitotic mitotic

pertaining to mitosis.


mitotic activity
degree to which a cell population is proliferating; used as an index of tumor aggression.
 kinesin Eg5 inhibitor, Kyowa Hakko's proprietary compound for anti-tumor agents.

Under the agreement terms, Eli Lilly will exclusively develop and market mitotic kinesin Eg5 worldwide except in Japan. Accordingly, Kyowa Hakko Kogyo receives an upfront payment, milestone payments and royalties on sales of commercialized products from Eli Lilly.

The compound, which specifically inhibits mitotic kinesin Eg5, arrests the cell division cycle of cancer cells at the mitotic phase and induces apoptosis. Since the compound does not interfere with the formulation of microtubules Microtubules
Slender, elongated anatomical channels in worms.

Mentioned in: Antihelminthic Drugs
, it is expected to develops no serious side effects Side effects

Effects of a proposed project on other parts of the firm.
 such as nerve disorders.

Going forward, Eli Lilly will take over the development of mitotic kinesin Eg5 inhibitor and plans to initiate clinical trials in the US and Europe. With this move, the two companies aim to introduce an innovative anti-tumor agent at the earliest date possible.

Copyright [c] 2006 Japan Corporate News Network. All rights reserved.
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Copyright 2006, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:JCNN News Summaries
Geographic Code:1USA
Date:Jan 11, 2006
Words:176
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