Kyowa Hakko Develops World's First Fermentation-based Commercial Production Method for L-Tyrosine.Tokyo, Japan, Sept 26, 2006 - (JCN) - Kyowa Hakko today announced that it has developed the world's first fermentation-based method for the commercial production of L-Tyrosine Tyr . The company plans to start full-scale production in 2007. A white crystalline amino acid that is derived from the hydrolysis of proteins such as casein and is a precursor of epinephrine, thyroxine, and melanin. L-Tyrosine is an amino acid branched-chain amino acids leucine, isoleucine, and valine. essential amino acids the nine a-amino acids that cannot be synthesized by humans but must be obtained from the diet. nonessential amino acids the eleven a-amino acids that can be synthesized by humans and are not specifically required in the diet. that is used as a nutritional ingredient in amino acid infusions and enteral nutritional products (medical foods). It is also reported to alleviate symptoms associated with stress, and consequently has been used as an ingredient in dietary supplements and health foods. The use of L-Tyrosine in pharmaceutical intermediates and other health-related products is expected to increse in the coming years. Previously, the main production methods for L-Tyrosine invloved animal protein, such as hair or feathers. Recently, however, to avoid the risk of spongiform spongiform /spon·gi·form/ (spun´ji-form) resembling a sponge. spon·gi·form (sp  n j+encephalopathy AIDS encephalopathy HIV e. anoxic encephalopathy hypoxic e. biliary encephalopathy , bilirubin encephalopathy kernicterus. bovine spongiform encephalopathy ">bovine spongiform encephalopathy bovine spongiform encephalopathy spongiform encephalopathyn. : see prion. (BSE or mad cow disease) and viruses from animal sources such as avian influenza, a growing number of consumers prefer products made from non-animal sources. Encephalopathy characterized by progressive diffuse vacuolation of the cerebral cortex. Although there are existing production methods that use plant sources, such as soybeans, it is difficult to produce large amounts at an economical price. In response, Kyowa Hakko developed a production method based on fermentation that is suitable for mass production of L-Tyrosine. The company discovered microorganisms with superior characteristics for the production of L-Tyrosine and drew on its advanced fermentation and purification technologies to perfect the new method, which will ensure the company's ability to provide a high quality and stable supply of L-Tyrosine to customers worldwide. Yukinobu Kotani, President of Kyowa Hakko's Bio-Chemicals Business Unit, said, "Now L-Tyrosine joins many other Kyowa Hakko products that are non-animal sourced, for example L-Hydroxyproline hydroxyproline /hy·droxy·pro·line/ (-pro´len) a hydroxylated form of proline, occurring in collagen and other connective tissue proteins. hy·drox·y·pro·line (h  -dr. This lineup is a clear indication of our competitive edge in fermentation technologies. We will continue working to supply fermented materials from non-animal sources to markets around the world, including materials that are now in test production." Kyowa Hakko was the first company in the world to succeed in commercial production of amino acids through fermentation. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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