Kronos Longevity Research Institute --KLRI-- Announces 5-Year Study on Risks and Benefits of Early Menopausal Hormone Therapy.Business Editors/Health/Medical Writers PHOENIX--(BUSINESS WIRE)--Oct. 7, 2003 Kronos Early Estrogen Prevention Study (KEEPS) Will Be a Randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. , Controlled Trial of 900 Women that Examines the Effects of Estrogen on the Progression of Atherosclerosis Kronos Longevity Research Institute (KLRI KLRI Korea Legislation Research Institute ) today announced plans for the Kronos Early Estrogen Prevention Study (KEEPS), a five-year study of female hormone replacement therapy Hormone Replacement Therapy Definition Hormone replacement therapy (HRT) is the use of synthetic or natural female hormones to make up for the decline or lack of natural hormones produced in a woman's body. aimed at providing prospective data on the risks and benefits of early menopausal hormonal intervention, particularly as it relates to the progression of atherosclerosis. Atherosclerosis is a medical condition in which fatty material is deposited along the walls of arteries. This fatty material thickens, hardens and may eventually block arteries and cause heart disease. The study also will compare conjugated oral with transdermal estrogen treatment to further elucidate the potential role of their differential actions in mediating adverse effects of menopausal hormone therapy (MHT MHT Multiple-Hypothesis Tracking MHT Male Hose Thread MHT Mental Health Team MHT Multiple Hypothesis Testing MHT Manchester, NH, USA - Manchester (Airport Code) MHT Multi-server Hyper-threading Transportation ). "Despite more than 40 years of research, menopausal hormone replacement therapy with estrogen or estrogen/progestin remains one of the most debatable areas in medicine," said Dr. S. Mitchell Harman, director of KLRI. "The controversial Women's Health Initiative Women's Health Initiative A 15-yr, $628 million project involving 1. An observational study of the health habits and medical Hx of ±100,000 ♀ 2. (WHI WHI Women's Health Initiative WHI Women's Health Issues (journal) WHI Women's Health Institute ) study has left many questions unanswered. We have concluded that additional trials of MHT in a target population much younger than the mean age of 62.7 that was studied in the WHI will be required to shed light on the risk-benefit ratio of early MHT." Prior to the WHI study, most data suggested that hormone replacement therapy was associated with a high degree of protection (40-60 percent reductions) against coronary heart disease coronary heart disease: see coronary artery disease. coronary heart disease or ischemic heart disease Progressive reduction of blood supply to the heart muscle due to narrowing or blocking of a coronary artery (see atherosclerosis). , all-cause mortality and osteoporotic fractures, in addition to a small increase in breast cancer risk. KEEPS DESIGN The Kronos Early Estrogen Prevention Study will be a randomized, placebo-controlled, double-blinded examination of healthy peri-menopausal women ages 45 to 54. Researchers will recruit 900 study participants at five yet-to-be-determined clinical trial sites. KLRI will serve as the coordinating center, but will not recruit study participants. For additional media materials or to request an interview, please contact Nick Quan or Stephanie Jarnagan at (602) 956-9934. |
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