Kidney, liver transplant study for people with HIV.Atlanta, Baltimore, Boston, Charlottesville, Chicago (2 Centers), Cincinnati, Cleveland, Los Angeles, Miami, New Orleans, New York New York, state, United States New York, Middle Atlantic state of the United States. It is bordered by Vermont, Massachusetts, Connecticut, and the Atlantic Ocean (E), New Jersey and Pennsylvania (S), Lakes Erie and Ontario and the Canadian province of (2 Centers), Philadelphia (2 Centers), Pittsburgh, San Francisco, Washington DC (2 Centers) This study of kidney and liver transplantation Liver Transplantation Definition Liver transplantation is a surgery that removes a diseased liver and replace it with a healthy donor liver. Purpose The liver is the body's principle chemical factory. for persons with HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. , by 19 transplant centers with funding from the U.S. National Institutes of Health is currently running and is open for new people Even for patients who do not need a transplant immediately but may need one in the future, it can be important to get into the system now to avoid delays if and when a transplant is necessary. Persons with hepatitis C Hepatitis C Definition Hepatitis C is a form of liver inflammation that causes primarily a long-lasting (chronic) disease. Acute (newly developed) hepatitis C is rarely observed as the early disease is generally quite mild. or hepatitis B Hepatitis B Definition Hepatitis B is a potentially serious form of liver inflammation due to infection by the hepatitis B virus (HBV). It occurs in both rapidly developing (acute) and long-lasting (chronic) forms, and is one of the most common chronic are not disqualified and will be considered for this study. Volunteers must: * Meet the criteria for transplantation; * Have a T-cell count greater than 100 (liver transplant) or greater than 200 (kidney transplant); * Meet HIV viral load HIV viral load AIDS A measure of the amount of HIV RNA in blood, expressed as number of copies/mL of plasma. See AIDS, HIV. criteria depending on which organ is needed; * Patients with certain opportunistic infections in the past will be considered, and need to have a T-cell count above 200; * Pediatric patients are being enrolled in several centers in cities listed above. For More Information Specific site and study information can be found at http://spitfire.emmes.com/study/htr/About_Us/about_us.html (might require Internet Explorer browser), or http://www.clinicaltrials.gov/ Related published literature can be found at http://spitfire.emmes.com/study/htr/Useful_Links/useful_links.html A poster at the recent Retroviruses conference reported the pilot study results so far: Michelle Roland, M.D., Don Stablein, Laurie Carlson, and others. 1- to 3-year outcomes in HIV-infected liver and kidney transplant recipients. 12th Conference on Retroviruses and Opportunistic Infections, Boston, February 22-25, 2005 [abstract 953]. This poster may be available at http://www.retroconference.org. |
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