Joining forces to understand Parkinson disease.Parkinson disease Parkinson Disease Definition
Parkinson disease (PD) is a progressive movement disorder marked by tremors, rigidity, slow movements (bradykinesia), and posture instability. (PD) continues to be a high research priority at the NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) . The institute currently supports a broad scope of research, from molecular epidemiology molecular epidemiology Molecular medicine An evolving field that combines the tools of standard epidemiology–case studies, questionnaires and monitoring of exposure to external factors with the tools of molecular biology–eg, restriction endonucleases, studies of environmental risk and protective factors for PD to basic laboratory invetigations aimed at developing new animal models, understanding the role of mitochondrial mitochondrial
pertaining to mitochondria.
a unique set of tRNAs, mRNAs, rRNAs, transcribed from mitochondrial DNA by a mitochondrial-specific RNA polymerase, that account for about 4% of the total cell RNA that oxidative damage in vulnerable cell populations, and defining transport mechanisms for toxicant toxicant /tox·i·cant/ (tok´si-kant)
1. A poison or poisonous agent.
2. An intoxicant.
adj. entry to the brain. Taken together, results from these studies provide strong support for the idea that typical late-onset PD reflects joint effects of environmental factors and genetic susceptibility.
The NIEHS has special interest in enabling the synthesis of findings emerging across disparate disciplines and research settings in the PD arena. The NIEHS Collaborative Centers for Parkinson's Disease Parkinson's disease or Parkinsonism, degenerative brain disorder first described by the English surgeon James Parkinson in 1817. When there is no known cause, the disease usually appears after age 40 and is referred to as Parkinson's disease. Environmental Research (CCPDER) Program was initiated in 2002 to strengthen the interchange among geneticists This is a list of people who have made notable contributions to genetics. The growth and development of genetics represents the work of many people. This list of geneticists is therefore by no means complete. Contributors of great distinction to genetics are not yet on the list. , clinicians, epidemiologists, and scientists engaged in fundamental laboratory research on PD. In June 2004, all NIEHS grantees in the area of neurodegeneration were brought together to share their most recent findings, and to identify and encourage new areas of collaboration among investigators. Most recently, the NIEHS partnered with the National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke is a part of the U.S. National Institutes of Health.
The NINDS conducts and supports research on brain and nervous system disorders. Created by the U.S. to support the development of a database, PD-DOC, that will enable sharing of clinical, pathological, biochemical, and risk factor information among researchers.
A high-priority need that has been identified by PD researchers is for improved methodologies to facilitate data pooling, combined analysis, and comparison of results across epidemiologic studies. In response to this need, the NIEHS has provided support through the CCPDER Program for two meetings that will bring together PD epidemiologists and related experts to develop a series of methodologic recommendations. These will include guidelines for ascertainment and case definition in epidemiologic field studies, and recommendations for both exposure assessment methods and a minimal data set of high-importance exposures to be collected in future investigations. Materials produced through this mechanism will be made widely available through venues such as the CCPDER website, and will be used to guide the development of the epidemiologic component of PD-DOC.
Collectively, these efforts are intended to improve the ability of epidemiologic researchers to identify novel genetic and environmental risk factors for PD, and to inform and be informed by mechanistic laboratory-based research. Ultimately, these data will provide a basis for devising strategies to prevent disease by avoiding or ameliorating harmful exposures and exploiting those exposures that confer protection.
Cindy Lawler, PhD | firstname.lastname@example.org