John Wayne Cancer Institute Receives Grant to Study Long-term Health Effects of Traumatic Brain Injuries.Research Will Focus on Relationship of Concussion, Pituitary pituitary /pi·tu·i·tary/ (pi-too´i-tar?e)
2. pituitary gland; see under gland.
anterior pituitary adenohypophysis. Hormonal Failure and Quality of Life in Retired National Football League Players
SANTA MONICA, Calif. -- The John Wayne Cancer Institute at Saint John's Health Center Saint John's Health Center is a hospital in Santa Monica, California, USA. The hospital was founded in 1942 by the Sisters of Charity of Leavenworth. New Construction announced today that it has received a grant from the National Operating Committee on Standards for Athletic Equipment to study pituitary hormonal failure (hypopituitarism Hypopituitarism Definition
Hypopituitarism is loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function. The pituitary gland is located at the base of the brain. ) in retired football players.
The research, which will be conducted in collaboration with the University of North Carolina's (UNC (Universal Naming Convention) A standard for identifying servers, printers and other resources in a network, which originated in the Unix community. A UNC path uses double slashes or backslashes to precede the name of the computer. ) Department of Exercise and Sport Science, and the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Harbor-UCLA Medical Center is a hospital located within the city of Torrance, California, USA. The hospital was founded in 1946, and is funded by Los Angeles County
Harbor-UCLA serves as the Level I Trauma Center for the South Bay area. , will be directed by Daniel F. Kelly, MD, director of the Neuro-Endocrine Tumor Center at the John Wayne Cancer Institute, and Kevin M. Guskiewicz, PhD, chairman of the Department of Exercise and Sport Science at UNC.
In a cohort of retired National Football League (NFL NFL
National Football League
NFL (US) n abbr (= National Football League) → Fußball-Nationalliga ) players, the study will examine the relationship between the number of concussions sustained in players' NFL careers, and their subsequent pituitary hormonal function and post-retirement quality of life. The investigators hypothesize hy·poth·e·size
v. hy·poth·e·sized, hy·poth·e·siz·ing, hy·poth·e·siz·es
To assert as a hypothesis.
To form a hypothesis. that players sustaining multiple concussions are at increased risk of developing pituitary hormonal dysfunction which may in turn contribute to problems of obesity, fatigue, impaired metabolism, depression, sexual dysfunction and a general poor quality of life.
According to Dr. Kelly, the new study will focus on a relatively unexplored area of traumatic brain injury Traumatic brain injury (TBI), traumatic injuries to the brain, also called intracranial injury, or simply head injury, occurs when a sudden trauma causes brain damage. TBI can result from a closed head injury or a penetrating head injury and is one of two subsets of acquired brain (TBI TBI 1. Thyroxine-binding index 2. Total body irradiation )--the potential correlation between recurrent concussions and pituitary hormonal dysfunction. More than 1.2 million Americans sustain a TBI annually, the majority of which are cerebral concussions. Repeat concussions have been shown to be a risk factor for neurodegenerative dementing disorders, including mild cognitive impairment mild cognitive impairment (MCI),
n memory loss generally associated with aging; does not affect normal independent functioning of an individual. and Alzheimer's Disease. However, little is known about the impact of single or multiple concussions on hormonal function and quality of life. Only in the sport of boxing, have a few small studies shown that boxers are at increased risk of developing pituitary failure. In contrast, it is well known that a single severe head injury can lead to pituitary damage and hormonal abnormalities in up to one third of individuals.
The pituitary is a small bean-shaped gland located immediately below the brain and behind the nasal cavity in the skull base; it is connected to the brain by the thin delicate vascular pituitary stalk. Weighing less than one gram, the pituitary is often called the "master gland" since it controls the secretion of the body's hormones. These essential substances when released by the pituitary into the blood stream have a broad range of effects on growth and development, sexuality and reproductive function, metabolism, the response to stress and overall quality of life.
"This research is long overdue," Dr. Kelly said. "Millions of young people and professional athletes participate in sports that put them at risk of concussion; not just football, but also hockey, rugby, soccer, baseball and basketball. We need to know more about how these so-called "minor head injuries" impact their lives in subsequent years, and in particular, whether multiple concussions can lead to pituitary hormonal failure and poor quality of life."
Using the database of the Center for the Study of Retired Athletes at University of North Carolina and in cooperation with the National Football League Players' Association, 90 study participants will be categorized based on the number of concussions they sustained during their NFL career. The retired players will then be assessed utilizing pituitary hormonal blood tests, body composition testing and neurobehavioral, quality of life and sexual function surveys. Retirees found to be deficient in any hormones such as thyroid, testosterone or growth hormone will be treated with physiological replacement doses of the appropriate hormone and will then have repeat quality of life testing. Hormonal testing assays will be conducted by the General Clinical Research Center at Harbor-UCLA Medical Center under the direction of Professor Christina Wang, an endocrinologist and a study co-investigator.
"The problem of sports-related concussions is increasingly recognized as a major contributor to long-term disability in many retired athletes," said Bob Klein, vice president at Saint John's Health Center and a ten-year NFL veteran with the Los Angeles Rams and San Diego Chargers
The Neuro-Endocrine Tumor Center (www.neuro-endo.org) is housed at Saint John's Health Center and the John Wayne Cancer Institute in Santa Monica, California For other uses, see Santa Monica (disambiguation).
Santa Monica is a coastal city in western Los Angeles County, California, USA. Situated on Santa Monica Bay of the Pacific Ocean, it is surrounded by the City of Los Angeles — Pacific Palisades and Brentwood on the north, . The Center's focus of activities is the treatment of pituitary tumors, brain tumors, and other neuro-endocrine disorders including pituitary hormonal deficiencies.
The Center for the Study of Retired Athletes at the University of North Carolina works in close affiliation with the National Football League Players Association The National Football League Players Association, or NFLPA, is the labor union of players in football's National Football League. It was founded in 1956, but only achieved recognition and a collective bargaining agreement several years later. . Since 2001, the Center has been investigating a spectrum of physical and mental disabilities common to retired athletes. The research team will begin work in July 2008, with initial research results expected in 2010.
Since its founding in 1942 by the Sisters of Charity of Leavenworth This article or section needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article. , Saint John's Health Center has been providing the patients and families of Santa Monica, West Los Angeles
Since 1981, the John Wayne name has been committed by the Wayne family to groundbreaking cancer research in memory of the much-loved actor who died of cancer. The John Wayne Cancer Institute has received worldwide acclaim for advances in understanding the disease, focusing on melanoma (skin cancer), breast, prostate, colon, pancreatic, lung and liver cancer, as well as lymphoma and leukemia. With its unique ability to rapidly turn scientific breakthroughs into innovative approaches to treatment and early detection, JWCI JWCI John Wayne Cancer Institute provides immediate hope to cancer patients from around the globe.